Literature summary for 3.4.21.61 extracted from

Mayer, G.; Hamelin, J.; Asselin, M.; Pasquato, A.; Marcinkiewicz, E.; Tang, M.; Tabibzadeh, S.; Seidah, N.G.
The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates (2008), J. Biol. Chem., 283, 2373-2384.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293 cells, COS-1 cells or Y1 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
DeltaN218	in COS-1 cells only apparent upon co-expression of PC5A. Untreated Y1 cells secrete PCSK9-DeltaN218, stimulation with 8-Br-cAMP increases the level and especially that of the 34-kDa PCSK9 product	Homo sapiens
R218S	noncleavable mutant	Homo sapiens
R469W	natural mutation, cannot modify the ability of PC5A to produce the 34-kDa PCSK9 product in HEK293 cells	Homo sapiens
R496W	natural mutation, cannot modify the ability of PC5A to produce the 34-kDa PCSK9 product in HEK293 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	PC5A inactivates PCSK9 via direct and indirect cleavages. PC5A, furin, or ADAMTS-4, but not ADAMTS-5, generate a 34-kDa PCSK9 product	Homo sapiens
TIMP-3	completely abolishes the production of the 34-kDa PCSK9 product	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
PCSK9	-	Homo sapiens

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Release 2023.1 (January 2023)