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Literature summary for 3.4.21.35 extracted from

  • Cloutier, S.M.; Chagas, J.R.; Mach, J.P.; Gygi, C.M.; Leisinger, H.J.; Deperthes, D.
    Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology (2002), Eur. J. Biochem., 269, 2747-2754.
    View publication on PubMed
Search for more literature for 3.4.21.35

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens involved in prostate cancer development ?
-
 ?
polypeptide + H2O Homo sapiens
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds strict preference for Arg in P1 position, wich is further enhanced by Ser in P1' position Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
96.5
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Val-Leu-Arg-p-nitroanilide + H2O weak activity Homo sapiens D-Val-Leu-Arg + p-nitroaniline
-
 ?
Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
additional information substrate specificty study by phage display Homo sapiens ?
-
 ?
additional information involved in prostate cancer development Homo sapiens ?
-
 ?
polypeptide + H2O
-
 Homo sapiens peptides
-
 ?
protein C inhibitor + H2O
-
 Homo sapiens ?
-
 ?
semenogelin I + H2O
-
 Homo sapiens semenogelin I fragments
-
 ?
semenogelin II + H2O
-
 Homo sapiens semenogelin II fragments
-
 ?