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Literature summary for 3.2.1.207 extracted from

  • Mora-Montes, H.; Bates, S.; Netea, M.; Di­az-Jimenez, D.; Lopez-Romero, E.; Zinker, S.; Ponce-Noyola, P.; Kullberg, B.; Brown, A.; Odds, F.; Flores-Carreon, A.; Gow, N.
    Endoplasmic reticulum alpha-glycosidases of Candida albicans are required for N glycosylation, cell wall integrity, and normal host-fungus interaction (2007), Eukaryot. Cell, 6, 2184-2193 .
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Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
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 Candida albicans 5783
-

Organism

Organism UniProt Comment Textmining
Candida albicans Q5A4X3
-
-
Candida albicans ATCC MYA-2876 Q5A4X3
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-

Synonyms

Synonyms Comment Organism
ROT2
-
 Candida albicans

General Information

General Information Comment Organism
physiological function enzyme null mutants tend to aggregate, display reduced growth rates, have a lower content of cell wall phosphomannan and other changes in cell wall composition, underglycosylated beta-N-acetylhexosaminidase, and have a constitutively activated PKC-Mkc1 cell wall integrity pathway. Cells are also attenuated in virulence in a murine model of systemic infection and stimulated an altered pro- and anti-inflammatory cytokine profile from human monocytes Candida albicans