Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-isobutyl-1-methylxanthine | - |
Mus musculus | |
3-isobutyl-1-methylxanthine | - |
Rattus norvegicus | |
carboxyamidotriazole | non-selective inhibition | Mus musculus | |
carboxyamidotriazole | non-selective inhibition | Rattus norvegicus | |
rolipram | - |
Mus musculus | |
rolipram | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | Mus musculus | - |
5'-AMP | - |
? | |
3',5'-cAMP + H2O | Rattus norvegicus | - |
5'-AMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
L-1210 cell | - |
Mus musculus | - |
Lewis lung carcinoma cell | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
lymphocytic leukemia cell | - |
Mus musculus | - |
peritoneal macrophage | - |
Mus musculus | - |
RAW-264.7 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Mus musculus | 5'-AMP | - |
? | |
3',5'-cAMP + H2O | - |
Rattus norvegicus | 5'-AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
adenosine 3',5'-cyclicmonophosphate-specific PDE | - |
Mus musculus |
adenosine 3',5'-cyclicmonophosphate-specific PDE | - |
Rattus norvegicus |
cAMP-PDE | - |
Mus musculus |
cAMP-PDE | - |
Rattus norvegicus |
cAMP-phosphodiesterase | - |
Mus musculus |
cAMP-phosphodiesterase | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000131 | - |
enzyme from lung, at pH 8.0 and 30°C | Mus musculus | rolipram | |
0.0000149 | - |
enzyme from RAW264.7 cells, at pH 8.0 and 30°C | Mus musculus | rolipram | |
0.0000188 | - |
enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C | Mus musculus | rolipram | |
0.0000943 | - |
enzyme from brain, at pH 8.0 and 30°C | Rattus norvegicus | rolipram | |
0.0000945 | - |
enzyme from peritoneal macrophage, at pH 8.0 and 30°C | Mus musculus | rolipram | |
0.00159 | - |
enzyme from peritoneal macrophage, at pH 8.0 and 30°C | Mus musculus | carboxyamidotriazole | |
0.00509 | - |
enzyme from lung, at pH 8.0 and 30°C | Mus musculus | carboxyamidotriazole | |
0.00562 | - |
enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C | Mus musculus | carboxyamidotriazole | |
0.00789 | - |
enzyme from L1210 cells, at pH 8.0 and 30°C | Mus musculus | carboxyamidotriazole | |
0.0112 | - |
enzyme from brain, at pH 8.0 and 30°C | Rattus norvegicus | carboxyamidotriazole | |
0.0262 | - |
enzyme from RAW264.7 cells, at pH 8.0 and 30°C | Mus musculus | carboxyamidotriazole |