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Information on EC 3.1.4.53 - 3',5'-cyclic-AMP phosphodiesterase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
IUBMB Comments
Requires Mg2+ or Mn2+ for activity . This enzyme is specific for 3',5'-cAMP and does not hydrolyse other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17, 3,5-cyclic-nucleotide phosphodiesterase and EC 3.1.4.35, 3,5-cyclic-GMP phosphodiesterase). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
3',5'-cAMP phosphodiesterase, 3',5'-cyclic AMP phosphodiesterase, adenosine 3',5'-cyclic monophosphate PDE, adenosine 3',5'-cyclicmonophosphate-specific PDE, cAMP phosphodiesterase, cAMP phosphodiesterase-4, cAMP-PDE, cAMP-phosphodiesterase, cAMP-phosphodiesterase 1C, cAMP-phosphodiesterase 4D7, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
adenosine 3',5'-cyclic phosphate + H2O = AMP
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PATHWAY SOURCE
PATHWAYS