Literature summary for 3.1.4.53 extracted from

Wang, Y.J.; Jiang, Y.L.; Tang, H.F.; Zhao, C.Z.; Chen, J.Q.
Zl-n-91, a selective phosphodiesterase 4 inhibitor, suppresses inflammatory response in a COPD-like rat model (2010), Int. Immunopharmacol., 10, 252-258.

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Inhibitors

Inhibitors	Comment	Organism	Structure
dexamethasone	dexmethasone at 0.1 mg/kg inhibits the activity of PDE4	Rattus norvegicus
rolipram	rolipram at 0.3 mg/kg inhibits the activity of PDE4	Rattus norvegicus
Zl-n-91	selective PDE4 inhibitor, Zl-n-91 at 0.03, 0.3 or 3 mg/kg dose dependently inhibits PDE4 activity	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3',5'-cAMP + H2O	Rattus norvegicus	-	5'-AMP	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cAMP + H2O	-	Rattus norvegicus	5'-AMP	-	?

Synonyms

Synonyms	Comment	Organism
PDE4	-	Rattus norvegicus
phosphodiesterase 4	-	Rattus norvegicus

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Release 2023.1 (January 2023)