Cloned (Comment) | Organism |
---|---|
expression in baculovirus transfected Sf9 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dipyridimole | - |
Homo sapiens | |
additional information | the enzyme is insensitive (up to 100 mM) to a variety of PDE inhibitors including rolipram, zaprinast, vinpocetine, SKF-94120, and IBMX | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000055 | - |
adenosine 3',5'-cyclic phosphate | - |
Homo sapiens | |
0.124 | - |
guanosine 3',5'-cyclic phosphate | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | the enzyme requires the presence of at least 1 mM Mn2+ or Mg2+ for maximal activity in vitro | Homo sapiens | |
Mn2+ | the enzyme requires the presence of at least 1 mM Mn2+ or Mg2+ for maximal activity in vitro | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60658 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
ovary | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenosine 3',5'-cyclic phosphate + H2O | - |
Homo sapiens | adenosine 5'-phosphate | - |
? | |
guanosine 3',5'-cyclic phosphate + H2O | - |
Homo sapiens | guanosine 5'-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cAMP-specific phosphodiesterase | - |
Homo sapiens |
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | - |
Homo sapiens |
PDE8A | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.009 | - |
- |
Homo sapiens | dipyridimole |