Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a target for anticancer therapy | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Saccharomyces cerevisiae | the enzyme hydrolyzes the covalent bond between the tyrosyl residue of topoisomerase 1 and the 3'-phosphate group in DNA. The enzyme is able to initiate the cleavage of internal apurinic/apyrimidinic sites or 3-hydroxy-2-hydroxymethyl tetrahydrofuran in DNA and its subsequent repair | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P38319 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme hydrolyzes the covalent bond between the tyrosyl residue of topoisomerase 1 and the 3'-phosphate group in DNA. The enzyme is able to initiate the cleavage of internal apurinic/apyrimidinic sites or 3-hydroxy-2-hydroxymethyl tetrahydrofuran in DNA and its subsequent repair | Saccharomyces cerevisiae | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 68000, calculated from amino acid sequence | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
TDP1 | - |
Saccharomyces cerevisiae |
tyrosyl-DNA phosphodiesterase 1 | - |
Saccharomyces cerevisiae |