Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Triton X-100 | about 60% stimulation, optimum activity at 0.02% | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D9A | mutant is inactive towards lysophosphatidic acids | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-palmitoyl-2-lyso-sn-glycerol 3-phosphate | 40 microM, about 50% inhibition | Homo sapiens | |
lauric acid | 40 microM, about 60% inhibition | Homo sapiens | |
lysophosphatidylcholine | - |
Homo sapiens | |
additional information | not inhibitory: 1-palmitoyl-sn-glycerol, 1-hexadecanol | Homo sapiens | |
palmitic acid | 40 microM, about 80% inhibition | Homo sapiens | |
stearic acid | about 20% inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
1-palmitoyl-2-lyso-sn-glycerol 3-phosphate | pH 7.0, 37°C | Homo sapiens | |
0.0059 | - |
1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate | pH 7.0, 37°C | Homo sapiens | |
0.0062 | - |
1-oleoyl-2-lyso-sn-glycerol 3-phosphate | pH 7.0, 37°C | Homo sapiens | |
0.0064 | - |
1-stearoyl-2-lyso-sn-glycerol 3-phosphate | pH 7.0, 37°C | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | in absence of Mg2+ activity towards 1-stearoyl-2-lyso-sn-glycerol 3-phosphate acid is significantly decreased | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate + H2O | - |
Homo sapiens | 1-arachidonoyl-sn-glycerol + phosphate | - |
? | |
1-oleoyl-2-lyso-sn-glycerol 3-phosphate + H2O | - |
Homo sapiens | 1-oleoyl-sn-glycerol + phosphate | - |
? | |
1-palmitoyl-2-lyso-sn-glycerol 3-phosphate + H2O | - |
Homo sapiens | 1-palmitoyl-sn-glycerol + phosphate | - |
? | |
1-stearoyl-2-lyso-sn-glycerol 3-phosphate + H2O | - |
Homo sapiens | 1-stearoyl-sn-glycerol + phosphate | - |
? | |
additional information | no substrates: dipalmitoyl phosphatidic acid, distearoyl phosphatidic acid | Homo sapiens | ? | - |
? |