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1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate + H2O
1-arachidonoyl-sn-glycerol + phosphate
1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphate + H2O
1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycerol + phosphate
1-lauroyl-2-lysophosphatidate + H2O
1-lauroyl-sn-glycerol + phosphate
-
-
-
-
?
1-myristoyl-2-lysophosphatidate + H2O
1-myristoyl-sn-glycerol + phosphate
-
-
-
-
?
1-myristoyl-sn-glycerol 3-phosphate + H2O
1-myristoylglycerol + phosphate
-
-
-
?
1-oleoyl-2-lyso-sn-glycerol 3-phosphate + H2O
1-oleoyl-sn-glycerol + phosphate
1-oleoyl-2-lysophosphatidate + H2O
oleic acid + sn-glycerol 3-phosphate
-
-
-
-
?
1-oleoyl-sn-glycerol 3-phosphate + H2O
1-oleoyl-sn-glycerol + phosphate
1-palmitoyl-2-lyso-sn-glycerol 3-phosphate + H2O
1-palmitoyl-sn-glycerol + phosphate
-
-
-
-
?
1-palmitoyl-2-lysophosphatidate + H2O
1-palmitoyl-sn-glycerol + phosphate
-
-
-
-
?
1-stearoyl-2-lyso-sn-glycerol 3-phosphate + H2O
1-stearoyl-sn-glycerol + phosphate
-
-
-
-
?
1-stearoyl-2-lyso-sn-glycerol 3-phosphate + H2O
1-stearoylglycerol + phosphate
-
-
-
?
1-stearoyl-2-lysophosphatidate + H2O
1-stearoyl-sn-glycerol + phosphate
-
-
-
-
?
attophos A + H2O
?
-
-
-
?
lysophosphatidate + H2O
monoacylglycerol + phosphate
lysophosphatidic acid + H2O
monoacylglycerol + phosphate
myristoyl-sn-glycerol3-phosphate + H2O
myristoyl-sn-glycerol + phosphate
best substrate
-
-
?
oleoyl-sn-glycerol 3-phosphate + H2O
oleoyl-sn-glycerol + phosphate
oleoyl-sn-glycerol-3-phosphate + H2O
oleoyl-sn-glycerol + phosphate
palmitoyl-sn-glycerol 3-phosphate + H2O
palmitoyl-sn-glycerol + phosphate
stearoyl-sn-glycerol 3-phosphate + H2O
stearoyl-sn-glycerol + phosphate
-
-
-
-
?
stearoyl-sn-glycerol-3-phosphate + H2O
stearoyl-sn-glycerol + phosphate
-
-
-
?
additional information
?
-
1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate + H2O
1-arachidonoyl-sn-glycerol + phosphate
-
-
-
-
?
1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate + H2O
1-arachidonoyl-sn-glycerol + phosphate
-
-
-
?
1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphate + H2O
1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycerol + phosphate
-
-
-
-
?
1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphate + H2O
1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycerol + phosphate
-
-
-
-
?
1-oleoyl-2-lyso-sn-glycerol 3-phosphate + H2O
1-oleoyl-sn-glycerol + phosphate
-
-
-
-
?
1-oleoyl-2-lyso-sn-glycerol 3-phosphate + H2O
1-oleoyl-sn-glycerol + phosphate
-
-
-
?
1-oleoyl-2-lyso-sn-glycerol 3-phosphate + H2O
1-oleoyl-sn-glycerol + phosphate
-
-
-
-
?
1-oleoyl-sn-glycerol 3-phosphate + H2O
1-oleoyl-sn-glycerol + phosphate
-
-
-
?
1-oleoyl-sn-glycerol 3-phosphate + H2O
1-oleoyl-sn-glycerol + phosphate
-
-
-
?
lysophosphatidate + H2O
monoacylglycerol + phosphate
-
best substrate
-
-
?
lysophosphatidate + H2O
monoacylglycerol + phosphate
-
-
-
-
?
lysophosphatidic acid + H2O
monoacylglycerol + phosphate
-
-
-
-
?
lysophosphatidic acid + H2O
monoacylglycerol + phosphate
-
-
-
-
?
oleoyl-sn-glycerol 3-phosphate + H2O
oleoyl-sn-glycerol + phosphate
-
-
-
-
?
oleoyl-sn-glycerol 3-phosphate + H2O
oleoyl-sn-glycerol + phosphate
about 2fold the activity of stearoyl-sn-glycerol 3-phosphate
-
-
?
oleoyl-sn-glycerol-3-phosphate + H2O
oleoyl-sn-glycerol + phosphate
-
-
-
-
?
oleoyl-sn-glycerol-3-phosphate + H2O
oleoyl-sn-glycerol + phosphate
-
-
-
-
?
palmitoyl-sn-glycerol 3-phosphate + H2O
palmitoyl-sn-glycerol + phosphate
-
-
-
-
?
palmitoyl-sn-glycerol 3-phosphate + H2O
palmitoyl-sn-glycerol + phosphate
-
-
-
?
additional information
?
-
-
the purified recombinant enzyme does not hydrolyze sphingosine 1-phosphate, diacylglycerol diphosphate, glycerol-3-phosphate, lysophosphatidylcholine, lysophosphatidylethanolamine and phosphatidate
-
-
?
additional information
?
-
-
the enzyme is specific to lysophosphatidic acid and does not utilize any other substrate such as glycerol-3-phosphate, phosphatidic acid, or p-nitrophenylphosphate
-
-
?
additional information
?
-
no substrates: cardiolipin, tetraoleoylbisphosphatidic acid, ceramide 1-phosphate or sphingosine 1-phosphate. The enzyme shows a slight activity towards phosphatidic acid (dioleolyl) and p-nitrophenyl phosphate in the neutral pH range around 7.5 and in the acidic pH range around 5.5, respectively
-
-
?
additional information
?
-
-
LPP is involved in regulation of bioactive lipids acting in signalling pathways, overview, LPP-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells
-
-
?
additional information
?
-
-
no substrates: dipalmitoyl phosphatidic acid, distearoyl phosphatidic acid
-
-
?
additional information
?
-
no substrate: glycerol 3-phosphate. Activity increases with the length of acyl chain to a peak value on 14:0-lysophosphatidic acid. Activity gradually decreases, when the substrate length is increased above the optimal 14:0-lysophosphatidic acid
-
-
?
additional information
?
-
-
no substrate: glycerol 3-phosphate. Activity increases with the length of acyl chain to a peak value on 14:0-lysophosphatidic acid. Activity gradually decreases, when the substrate length is increased above the optimal 14:0-lysophosphatidic acid
-
-
?
additional information
?
-
no substrate: phosphatidylglycerol phosphate
-
-
?
additional information
?
-
-
no substrate: phosphatidylglycerol phosphate
-
-
?
additional information
?
-
-
LPP is involved in regulation of bioactive lipids acting in signalling pathways, overview, LPP-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in epithelial cells
-
-
?
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1-oleoyl-sn-glycerol 3-phosphate + H2O
1-oleoyl-sn-glycerol + phosphate
-
-
-
?
lysophosphatidate + H2O
monoacylglycerol + phosphate
-
best substrate
-
-
?
lysophosphatidic acid + H2O
monoacylglycerol + phosphate
myristoyl-sn-glycerol3-phosphate + H2O
myristoyl-sn-glycerol + phosphate
best substrate
-
-
?
oleoyl-sn-glycerol 3-phosphate + H2O
oleoyl-sn-glycerol + phosphate
palmitoyl-sn-glycerol 3-phosphate + H2O
palmitoyl-sn-glycerol + phosphate
stearoyl-sn-glycerol 3-phosphate + H2O
stearoyl-sn-glycerol + phosphate
-
-
-
-
?
stearoyl-sn-glycerol-3-phosphate + H2O
stearoyl-sn-glycerol + phosphate
-
-
-
?
additional information
?
-
lysophosphatidic acid + H2O
monoacylglycerol + phosphate
-
-
-
-
?
lysophosphatidic acid + H2O
monoacylglycerol + phosphate
-
-
-
-
?
oleoyl-sn-glycerol 3-phosphate + H2O
oleoyl-sn-glycerol + phosphate
-
-
-
-
?
oleoyl-sn-glycerol 3-phosphate + H2O
oleoyl-sn-glycerol + phosphate
about 2fold the activity of stearoyl-sn-glycerol 3-phosphate
-
-
?
palmitoyl-sn-glycerol 3-phosphate + H2O
palmitoyl-sn-glycerol + phosphate
-
-
-
-
?
palmitoyl-sn-glycerol 3-phosphate + H2O
palmitoyl-sn-glycerol + phosphate
-
-
-
?
additional information
?
-
-
LPP is involved in regulation of bioactive lipids acting in signalling pathways, overview, LPP-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells
-
-
?
additional information
?
-
no substrate: glycerol 3-phosphate. Activity increases with the length of acyl chain to a peak value on 14:0-lysophosphatidic acid. Activity gradually decreases, when the substrate length is increased above the optimal 14:0-lysophosphatidic acid
-
-
?
additional information
?
-
-
no substrate: glycerol 3-phosphate. Activity increases with the length of acyl chain to a peak value on 14:0-lysophosphatidic acid. Activity gradually decreases, when the substrate length is increased above the optimal 14:0-lysophosphatidic acid
-
-
?
additional information
?
-
-
LPP is involved in regulation of bioactive lipids acting in signalling pathways, overview, LPP-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in epithelial cells
-
-
?
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0.0059 - 0.013
1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate
0.0051
1-myristoyl-sn-glycerol 3-phosphate
pH 7.0, 30°C
0.0062 - 0.0069
1-oleoyl-2-lyso-sn-glycerol 3-phosphate
0.038
1-oleoyl-sn-glycerol 3-phosphate
pH 7.5, 37°C
0.003
1-palmitoyl-2-lyso-sn-glycerol 3-phosphate
-
pH 7.0, 37°C
0.0064
1-stearoyl-2-lyso-sn-glycerol 3-phosphate
-
pH 7.0, 37°C
0.0042
1-stearyl-2-lyso-sn-glycerol 3-phosphate
pH 7.0, 30°C
0.0286
oleoyl-sn-glycerol 3-phosphate
-
pH 7.0, 30°C, presence of Triton X-100
0.034
oleoyl-sn-glycerol-3-phosphate
-
pH 6.5, 30°C
0.0479
palmitoyl-sn-glycerol 3-phosphate
-
pH 7.0, 30°C, presence of Triton X-100
0.0393
stearoyl-sn-glycerol 3-phosphate
-
pH 7.0, 30°C, presence of Triton X-100
0.0059
1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate
-
pH 7.0, 37°C
0.013
1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate
pH 7.0, 30°C
0.0062
1-oleoyl-2-lyso-sn-glycerol 3-phosphate
-
pH 7.0, 37°C
0.0069
1-oleoyl-2-lyso-sn-glycerol 3-phosphate
pH 7.0, 30°C
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malfunction
-
suppression of cardiac PAP1 activity/lipin expression may contribute to metabolic dysfunction of the diabetic heart
malfunction
-
suppression of cardiac PAP1 activity/lipin expression may contribute to metabolic dysfunction of the diabetic heart
physiological function
-
atrial tissue displays PAP1 activity that is 33% lower in those having type 2 diabetes mellitus than in non-diabetic controls
physiological function
-
compared to non-diabetic littermates, left ventricular PAP1 activity is 29% lower in 8-months-old Zucker diabetic fatty rats. Left ventricular PAP1 activities are 2.1fold (diabetic fatty rats) and 3.6fold (non-diabetic rats) higher than the respective atrial activities
physiological function
-
lysophosphatidate phosphatase plays a significant role in supplying the phosphate during phosphate-deficient conditions
physiological function
-
the low expression of lipid phosphate phosphatase in many tumor cells makes them hypersensitive to growth promoting and survival signals that are provided by lysophosphatidate, S1P, platelet-derived growth factor and epidermal growth factor. The intracellular actions of the enzyme controls cell migration, division, angiogenesis and chemoresistance. Increased LPP1 expression attenuates lysophosphatidate-induced migration of fibroblasts
physiological function
bifunctional enzyme displaying C-terminal epoxide hydrolase and N-terminal phosphatase activity. The phosphatase activity represents a 20-60% of lysophosphatidic acid cellular hydrolysis, especially in the cytosol
physiological function
-
a gene deletion mutant shows decreased lysophosphatidic acid-hydrolyzing activity under phosphate-limiting conditions. Overexpression of PHM8 in yeast results in an increase in the lysophosphatidic acid phosphatase activity in vivo
physiological function
gain-of-function mutations in TP53 downregulate the lysophosphatidic acid phosphatase type 6 (ACP6), leading to upregulation of focal adhesion signaling in an lysophosphatidic acid-dependent manner. Highly expressed in normal fallopian tube epithelium, ACP6 expression is significantly reduced in ovarian cancer tumors and early in situ lesions
physiological function
-
a gene deletion mutant shows decreased lysophosphatidic acid-hydrolyzing activity under phosphate-limiting conditions. Overexpression of PHM8 in yeast results in an increase in the lysophosphatidic acid phosphatase activity in vivo
-
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Zhao, Y.; Usatyuk, P.V.; Cummings, R.; Saatian, B.; He, D.; Watkins, T.; Morris, A.; Spannhake, E.W.; Brindley, D.; Natarajan, V.
Lipid phosphate phosphatase-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells
Biochem. J.
385
493-502
2005
Homo sapiens, Mus musculus
brenda
Reddy, V.S.; Rao, D.K.; Rajasekharan, R.
Functional characterization of lysophosphatidic acid phosphatase from Arabidopsis thaliana
Biochim. Biophys. Acta
1801
455-461
2010
Arabidopsis thaliana
brenda
Burgdorf, C.; Haensel, L.; Heidbreder, M.; Joehren, O.; Schuette, F.; Schunkert, H.; Kurz, T.
Suppression of cardiac phosphatidate phosphohydrolase 1 activity and lipin mRNA expression in Zucker diabetic fatty rats and humans with type 2 diabetes mellitus
Biochem. Biophys. Res. Commun.
390
165-170
2009
Homo sapiens, Rattus norvegicus
brenda
Samadi, N.; Bekele, R.; Capatos, D.; Venkatraman, G.; Sariahmetoglu, M.; Brindley, D.N.
Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance
Biochimie
93
61-70
2011
Mus musculus
brenda
Morisseau, C.; Schebb, N.H.; Dong, H.; Ulu, A.; Aronov, P.A.; Hammock, B.D.
Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids
Biochem. Biophys. Res. Commun.
419
796-800
2012
Homo sapiens (P34913)
brenda
Oguro, A.; Imaoka, S.
Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase
J. Lipid Res.
53
505-512
2012
Homo sapiens
brenda
Hiroyama, M.; Takenawa, T.
Purification and characterization of a lysophosphatidic acid-specific phosphatase
Biochem. J.
336 ( Pt 2)
483-489
1998
Bos taurus (A6H757)
brenda
Hiroyama, M.; Takenawa, T.
Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis
J. Biol. Chem.
274
29172-29180
1999
Homo sapiens (Q9NPH0), Homo sapiens
brenda
Reddy, V.S.; Singh, A.K.; Rajasekharan, R.
The Saccharomyces cerevisiae PHM8 gene encodes a soluble magnesium-dependent lysophosphatidic acid phosphatase
J. Biol. Chem.
283
8846-8854
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
brenda
Shekar, S.; Tumaney, A.W.; Rao, T.J.; Rajasekharan, R.
Isolation of lysophosphatidic acid phosphatase from developing peanut cotyledons
Plant Physiol.
128
988-996
2002
Arachis hypogaea
brenda
Li, J.; Dong, Y.; Lue, X.; Wang, L.; Peng, W.; Zhang, X.C.; Rao, Z.
Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6
Protein Cell
4
548-561
2013
Homo sapiens (Q9NPH0), Homo sapiens
brenda
Chryplewicz, A.; Tienda, S.M.; Nahotko, D.A.; Peters, P.N.; Lengyel, E.; Eckert, M.A.
Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6
Sci. Rep.
9
5195
2019
Homo sapiens (Q9NPH0)
brenda