Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | insulin therapy increases both PAP1 activity and lipin mRNA expression in diabetic patients | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | presence of lipin-1 and lipin-3, lipin-2 is absent. Marked differences in cardiac distribution of PAP1 | Rattus norvegicus | - |
left ventricle | - |
Rattus norvegicus | - |
additional information | atrial tissue | Homo sapiens | - |
Storage Stability | Organism |
---|---|
-80°C | Homo sapiens |
-80°C | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphate + H2O | - |
Homo sapiens | 1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycerol + phosphate | - |
? | |
1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphate + H2O | - |
Rattus norvegicus | 1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycerol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipin | - |
Homo sapiens |
lipin | - |
Rattus norvegicus |
lipin-1 | - |
Homo sapiens |
lipin-1 | - |
Rattus norvegicus |
lipin-3 | - |
Homo sapiens |
lipin-3 | - |
Rattus norvegicus |
PAP1 | - |
Homo sapiens |
PAP1 | - |
Rattus norvegicus |
phosphatidate phosphohydrolase 1 | - |
Homo sapiens |
phosphatidate phosphohydrolase 1 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | atrial lipin-1 and lipin-3 mRNA expression in diabetic patients is 50% and 59% lower as in non-diabetic patients, respectively | down |
Rattus norvegicus | PAP1 activity is highly related with cardiac lipin-1 and lipin-3 mRNA expression in Zucker diabetic fatty rats | additional information |
Homo sapiens | insulin therapy increases both PAP1 activity and lipin mRNA expression in diabetic patients | up |
Rattus norvegicus | left ventricular lipin-1 and lipin-3 expression is 7- to 27fold higher than respective atrial mRNA expression n Zucker diabetic fatty rats | up |
General Information | Comment | Organism |
---|---|---|
malfunction | suppression of cardiac PAP1 activity/lipin expression may contribute to metabolic dysfunction of the diabetic heart | Homo sapiens |
malfunction | suppression of cardiac PAP1 activity/lipin expression may contribute to metabolic dysfunction of the diabetic heart | Rattus norvegicus |
physiological function | atrial tissue displays PAP1 activity that is 33% lower in those having type 2 diabetes mellitus than in non-diabetic controls | Homo sapiens |
physiological function | compared to non-diabetic littermates, left ventricular PAP1 activity is 29% lower in 8-months-old Zucker diabetic fatty rats. Left ventricular PAP1 activities are 2.1fold (diabetic fatty rats) and 3.6fold (non-diabetic rats) higher than the respective atrial activities | Rattus norvegicus |