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Literature summary for 3.1.3.106 extracted from
- Lipid phosphate phosphatase-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells (2005), Biochem. J., 385, 493-502.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of myc-tagged wild-type human and mouse LPP-1 isozyme or Myc-tagged human and mouse LPP-1 mutant R217K in primary bronchial epithelial cells | Homo sapiens |
| expression of myc-tagged wild-type LPP-1 isozyme or Myc-tagged recombinant LPP-1 mutant R217K in human primary bronchial epithelial cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R217K | adenoviral construction of an inactive isozyme LPP-1 mutant | Homo sapiens |
| R217K | adenoviral construction of an isozyme LPP-1 mouse mutant showing partially attenuated LPA-induced interleukin-8 secretion without alteration of LPA-induced changes in intracellular Ca2+ concentration | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | outside surface, ecto-enzyme | Mus musculus | 5886 | - |
| plasma membrane | outside surface, ecto-enzyme | Homo sapiens | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lysophosphatidic acid + H2O | Mus musculus | - |
monoacylglycerol + phosphate | - |
? |  |
| lysophosphatidic acid + H2O | Homo sapiens | - |
monoacylglycerol + phosphate | - |
? | |
| additional information | Mus musculus | LPP is involved in regulation of bioactive lipids acting in signalling pathways, overview, LPP-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in epithelial cells | ? | - |
? | |
| additional information | Homo sapiens | LPP is involved in regulation of bioactive lipids acting in signalling pathways, overview, LPP-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epithelial cell | - |
Mus musculus | - |
| HBEpC cell | primary bronchial epithelial cells | Homo sapiens | - |
| lung | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
recombinant activity of wild-type and mutant enzymes in transformed cells | Mus musculus |
| additional information | - |
recombinant activity of wild-type and mutant enzymes in transformed cells | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-oleoyl-2-lyso-sn-glycerol 3-phosphate + H2O | - |
Mus musculus | 1-oleoyl-sn-glycerol + phosphate | - |
? | |
| 1-oleoyl-2-lyso-sn-glycerol 3-phosphate + H2O | - |
Homo sapiens | 1-oleoyl-sn-glycerol + phosphate | - |
? | |
| lysophosphatidic acid + H2O | - |
Mus musculus | monoacylglycerol + phosphate | - |
? | |
| lysophosphatidic acid + H2O | - |
Homo sapiens | monoacylglycerol + phosphate | - |
? | |
| additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, overview, LPP-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in epithelial cells | Mus musculus | ? | - |
? | |
| additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, overview, LPP-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipid phosphate phosphatase | - |
Mus musculus |
| lipid phosphate phosphatase | - |
Homo sapiens |
| LPP | - |
Mus musculus |
| LPP | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
| 7.5 | - |
assay at | Homo sapiens |
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