Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-(acyloxy)acyl group of bacterial toxin | Mus musculus | deacylation greatly reduces the ability of lipopolysaccharide to stimulate cells via CD14-MD-2-Toll-like receptor 4. Cortical tubule cells may produce and secrete the enzyme to limit inflammatory responses to gram-negative bacteria throughout the urinary tract | 3-hydroxyacyl group of bacterial toxin + a fatty acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O35298 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | proximal tubule cells secrete the pro-enzyme, which can be taken up by bladder cells and processed to the heterodimeric, more enzymatically active, mature enzyme form | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gut | low activity | Mus musculus | - |
liver | low activity | Mus musculus | - |
renal cortex | renal corticular tubule cells produce AOAH and secrete it into urine, where it can deacylate lipopolysaccharides | Mus musculus | - |
spleen | low activity | Mus musculus | - |
urinary tract | renal corticular tubule cells produce AOAH and secrete it into urine, where it can deacylate lipopolysaccharides | Mus musculus | - |
urine | renal corticular tubule cells produce AOAH and secrete it into urine, where it can deacylate lipopolysaccharides | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-(acyloxy)acyl group of bacterial toxin | deacylation greatly reduces the ability of lipopolysaccharide to stimulate cells via CD14-MD-2-Toll-like receptor 4. Cortical tubule cells may produce and secrete the enzyme to limit inflammatory responses to gram-negative bacteria throughout the urinary tract | Mus musculus | 3-hydroxyacyl group of bacterial toxin + a fatty acid | - |
? | |
3-(acyloxy)acyl group of bacterial toxin | Salmonella enterica serovar typhimurium lipopolysaccharide is used as substrate | Mus musculus | 3-hydroxyacyl group of bacterial toxin + a fatty acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AOAH | - |
Mus musculus |