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Literature summary for 3.1.1.77 extracted from

  • feulner, J.A.; Lu, M.; Shelton, J.M.; Zhang, M.; Richardson, J.A.; Munford, R.S.
    Identification of acyloxyacyl hydrolase, a lipopolysaccharide-detoxifying enzyme, in the murine urinary tract (2004), Infect. Immun., 72, 3171-3178.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin Mus musculus deacylation greatly reduces the ability of lipopolysaccharide to stimulate cells via CD14-MD-2-Toll-like receptor 4. Cortical tubule cells may produce and secrete the enzyme to limit inflammatory responses to gram-negative bacteria throughout the urinary tract 3-hydroxyacyl group of bacterial toxin + a fatty acid
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Organism

Organism UniProt Comment Textmining
Mus musculus O35298
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification proximal tubule cells secrete the pro-enzyme, which can be taken up by bladder cells and processed to the heterodimeric, more enzymatically active, mature enzyme form Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
gut low activity Mus musculus
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liver low activity Mus musculus
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renal cortex renal corticular tubule cells produce AOAH and secrete it into urine, where it can deacylate lipopolysaccharides Mus musculus
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spleen low activity Mus musculus
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urinary tract renal corticular tubule cells produce AOAH and secrete it into urine, where it can deacylate lipopolysaccharides Mus musculus
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urine renal corticular tubule cells produce AOAH and secrete it into urine, where it can deacylate lipopolysaccharides Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin deacylation greatly reduces the ability of lipopolysaccharide to stimulate cells via CD14-MD-2-Toll-like receptor 4. Cortical tubule cells may produce and secrete the enzyme to limit inflammatory responses to gram-negative bacteria throughout the urinary tract Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid
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?
3-(acyloxy)acyl group of bacterial toxin Salmonella enterica serovar typhimurium lipopolysaccharide is used as substrate Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid
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?

Synonyms

Synonyms Comment Organism
AOAH
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Mus musculus