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3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
diacylglycerol + H2O
?
-
in vitro
-
-
?
diacylphosphatidylethanolamine + H2O
?
-
-
-
-
?
glycerophospholipid + H2O
?
-
in vitro
-
-
?
lipopolysaccharide + H2O
?
long chain lipopolysaccharide + H2O
?
-
-
-
-
?
lysophospholipid + H2O
?
-
in vitro
-
-
?
medium chain lipopolysaccharide + H2O
?
-
-
-
-
?
short chain lipopolysaccharide + H2O
?
-
-
-
-
?
sn-1,2-dipalmitoylglycerol + H2O
palmitate + glycerol
-
in vitro
-
?
sn-1,2-dipalmitoylphosphatidylcholine + H2O
palmitate + phosphatidylcholine
-
in vitro
-
?
additional information
?
-
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
deacylation greatly reduces the ability of lipopolysaccharide to stimulate cells via CD14-MD-2-Toll-like receptor 4. Cortical tubule cells may produce and secrete the enzyme to limit inflammatory responses to gram-negative bacteria throughout the urinary tract
-
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
the major mammalian enzyme that deacylates the lipopolysaccharides contained in phygocytosed bacteria. The enzymatic deacylation of lipopolysaccharides is an intrinsic, regulated mechanism by which dendritic cells may modulate host response to this potent bacterial agonist
-
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
Salmonella enterica serovar typhimurium lipopolysaccharide is used as substrate
-
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
smooth LPS deacylated more slowly than rough LPS
palmitoleate released more slowly than myristate and laurate, 2-hydroxylaurate released more slowly than laurate
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
host AOAH selectively removes the secondary fatty acyl chains from bacterial lipopolysaccharides, that are required for lipopolysaccharide recognition by its mammalian signaling receptor, MD-2-TLR4. Possibility that AOAH, by inactivating bacterial lipopolysaccharide within the liver and spleen, is an important endogenous control mechanism. Recombinant AOAH restores hepatic LPS deacylation and prevented LPS-induced hepatomegaly in Aoah-/- mice
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of lipopolysaccharide
-
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
-
-
?
lipopolysaccharide + H2O
?
-
-
-
-
?
lipopolysaccharide + H2O
?
-
-
-
-
?
lipopolysaccharide + H2O
?
-
-
-
-
?
additional information
?
-
a decrease in neutrophil AOAH activity results in the appearance of lipopolysaccharide in the blood. Low blood neutrophil deacylation activity could be considered as a risk factor for severe clinical coliform mastitis
-
-
?
additional information
?
-
-
a decrease in neutrophil AOAH activity results in the appearance of lipopolysaccharide in the blood. Low blood neutrophil deacylation activity could be considered as a risk factor for severe clinical coliform mastitis
-
-
?
additional information
?
-
-
different lipids as substrates
-
-
?
additional information
?
-
-
endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase
-
-
?
additional information
?
-
polymorphisms in markers within the acyloxyacyl hydroxylase gene are associated with the risk of asthma and associated quantitative traits (IgE and cytokine levels) among asthmatic subjects and their families in Barbados
-
-
?
additional information
?
-
-
the enzyme inactivates lipopolysaccharides deacylating secondary fatty acyl chains on the lipid A moiety of lipopolysaccharide
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
host AOAH selectively removes the secondary fatty acyl chains from bacterial lipopolysaccharides, that are required for lipopolysaccharide recognition by its mammalian signaling receptor, MD-2-TLR4. Possibility that AOAH, by inactivating bacterial lipopolysaccharide within the liver and spleen, is an important endogenous control mechanism. Recombinant AOAH restores hepatic LPS deacylation and prevented LPS-induced hepatomegaly in Aoah-/- mice
-
-
?
additional information
?
-
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
deacylation greatly reduces the ability of lipopolysaccharide to stimulate cells via CD14-MD-2-Toll-like receptor 4. Cortical tubule cells may produce and secrete the enzyme to limit inflammatory responses to gram-negative bacteria throughout the urinary tract
-
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
the major mammalian enzyme that deacylates the lipopolysaccharides contained in phygocytosed bacteria. The enzymatic deacylation of lipopolysaccharides is an intrinsic, regulated mechanism by which dendritic cells may modulate host response to this potent bacterial agonist
-
-
?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
-
detoxification of LPS
-
?
additional information
?
-
a decrease in neutrophil AOAH activity results in the appearance of lipopolysaccharide in the blood. Low blood neutrophil deacylation activity could be considered as a risk factor for severe clinical coliform mastitis
-
-
?
additional information
?
-
-
a decrease in neutrophil AOAH activity results in the appearance of lipopolysaccharide in the blood. Low blood neutrophil deacylation activity could be considered as a risk factor for severe clinical coliform mastitis
-
-
?
additional information
?
-
-
endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase
-
-
?
additional information
?
-
polymorphisms in markers within the acyloxyacyl hydroxylase gene are associated with the risk of asthma and associated quantitative traits (IgE and cytokine levels) among asthmatic subjects and their families in Barbados
-
-
?
additional information
?
-
-
the enzyme inactivates lipopolysaccharides deacylating secondary fatty acyl chains on the lipid A moiety of lipopolysaccharide
-
-
?
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malfunction
-
transgenic mice overexpressing AOAH in dendritic cells and macrophages deacylate lipopolysaccharide more rapidly than wildtype controls. Transgenic mice are also protected from lipopolysaccharide-induced hepatosplenomegaly, recover more quickly from lipopolysaccharide-induced weight loss, and are more likely to survive when challenged with live Escherichia coli
malfunction
-
Aoah-/- mice with low doses of bacterial lipopolysaccharide, from from Escherichia coli strain O14, or Gram-negative bacteria have livers remaining enlarged, as much as 80% above normal, many weeks longer than do the livers of Aoah+/+ animals. When compared with livers from bacterial lipopolysaccharide-primed Aoah+/+ mice, bacterial lipopolysaccharide-primed Aoah-/- livers have more numerous and larger Kupffer cells, intrasinusoidal leukocyte aggregates and activated sinusoidal endothelial cells, and sustained production of interleukin-10 and mRNAs for tumor necrosis factor, interleukin-10, and IRAKM, phenotype, overview
malfunction
-
acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 polarization and immunity due to altered inactivation of commensal lipopolysaccharides. Lipopolysaccharide-containing Gram-negative microbiota augment the differentiation of antigen-specific Th17 cells
physiological function
-
acyloxyacyl hydrolase acts as one of the diverse antimicrobial peptides and proteins expressed in the placenta
physiological function
-
bacterial lipopolysaccharide, from Escherichia coli strain O14, induce hepatomegaly in mice, a recovery requires the murine enzyme, acyloxyacyl hydrolase, that inactivates bacterial lipopolysaccharide, overview
physiological function
-
acyloxyacyl hydrolase is a mammalian enzyme expressed by antigen-presenting cells that deacylates and thereby inactivates lipopolysaccharide in host tissues. Deacylated lipopolysaccharide does not activate TLR4 and competitively inhibits signaling by biologically active lipopolysaccharide. The enzyme shows ability to modulate microbial signals that influence mucosal T cell immunity. Colonic dendritic cell subset (CD103+CD11beta+ALDH-) display a unique capacity to both express the enzyme and polarize interleukin 17-secreting CD4+ helper T cells, Th17 cells
physiological function
alveolar macrophages increase Aoah expression upon exposure to lipopolysaccharide and Aoah+/+ mice recover more rapidly than Aoah-/- mice from acute lung injury induced by nasally instilled lipopolysaccharide or Klebsiella pneumoniae. Aoah-/- mouse lungs have more prolonged leukocyte infiltration, greater pro- and anti-inflammatory cytokine expression, and longer lasting alveolar barrier damage. The persistently bioactive lipopolysaccharide in Aoah-/- alveoli can stimulate alveolar macrophages directly and epithelial cells indirectly to produce chemoattractants that recruit neutrophils to the lung and may prevent their clearance. Alveolar macrophages that lack AOAH maintain or increase their responses to bioactive lipopolysaccharides and sustained inflammation
physiological function
in a murine neurogenic cystitis model, the gene encoding acyloxyacyl hydrolase is induced in the sacral spinal cord of pseudorabies virus-infected mice. Aoah-deficient mice exhibit increased vesicomotor reflex in response to bladder distension, consistent with spontaneous bladder hypersensitivity, and increased pelvic allodynia in neurogenic cystitis and postbacterial chronic pain models. Aoah deficiency results in greater bladder pathology and tumor necrosis factor production in pseudorabies virus neurogenic cystitis. Aoah-deficient mice have significantly higher levels of bladder vascular endothelial growth factor
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Erwin, A.L.; Munford, R.S.
Deacylation of structurally diverse lipopolysaccharides by human acyloxyacyl hydrolase
J. Biol. Chem.
265
16444-16449
1990
Homo sapiens
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Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides
Biochemistry
30
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Homo sapiens
brenda
Munford, R.S.; Hunter, J.P.
Acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides, has phospholipase, lysophospholipase, diacylglycerollipase, and acyltransferase activities in vitro
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Homo sapiens
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Detoxification of bacterial lipopolysaccharides (endotoxins) by a human neutrophil enzyme
Science
234
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1986
Homo sapiens
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Munford, R.S.; Hall, C.L.
Purification of acyloxyacyl hydrolase, a leukocyte enzyme that removes secondary acyl chains from bacterial lipopolysaccharides
J. Biol. Chem.
264
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1989
Homo sapiens
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Mc Dermott, C.M.; Cullor, J.S.; Fenwick, B.W.
Intracellular and extracellular enzymatic deacylation of bacterial endotoxin during localized inflammation induced by Escherichia coli
Infect. Immun.
59
487-485
1991
Bos taurus, Homo sapiens
-
brenda
Munford, R.S.; Erwin, A.L.
Eukaryotic lipopolysaccharide deacylation enzyme
Methods Enzymol.
209
485-492
1992
Homo sapiens
brenda
Staab, J.F.; Ginkel, D.L.; Rosenberg, G.B.; Munford, R.S.
A saposin-like domain influences the intracellular localization, stability, and catalytic activity of human acyloxyacyl hydrolase
J. Biol. Chem.
269
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1994
Homo sapiens
brenda
Cody, M.J.; Salkowski, C.A.; Henricson, B.E.; Detore, G.R.; Munford, R.S.; Vogel, S.N.
Effect of inflammatory and anti-inflammatory stimuli on acyloxyacyl hydrolase activity in murine macrophages
J. Endotoxin Res.
4
371-379
1997
Mus musculus
-
brenda
Staab, J.F.; Fosmire, S.; Zhang, M.; Varley, A.W.; Munford, R.S.
Distinctive structural features are shared by human, lapine, and murine acloxyacyl hydrolases
J. Endotoxin Res.
5
205-208
1999
Oryctolagus cuniculus, Homo sapiens, Mus musculus
-
brenda
feulner, J.A.; Lu, M.; Shelton, J.M.; Zhang, M.; Richardson, J.A.; Munford, R.S.
Identification of acyloxyacyl hydrolase, a lipopolysaccharide-detoxifying enzyme, in the murine urinary tract
Infect. Immun.
72
3171-3178
2004
Mus musculus (O35298), Mus musculus
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Lu, M.; Zhang, M.; Kitchens, R.L.; Fosmire, S.; Takashima, A.; Munford, R.S.
Stimulus-dependent deacylation of bacterial lipopolysaccharide by dendritic cells
J. EXp. Med.
197
1745-1754
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Barnes, K.C.; Grant, A.; Gao, P.; Baltadjieva, D.; Berg, T.; Chi, P.; Zhang, S.; Zambelli-Weiner, A.; Ehrlich, E.; Zardkoohi, O.; Brummet, M.E.; Stockton, M.; Watkins, T.; Gao, L.; Gittens, M.; Wills-Karp, M.; Cheadle, C.; Beck, L.A.; Beaty, T.H.; Becker, K.G.; garcia, J.G.N.; Mathias, R.A.
Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes
J. Allergy Clin. Immunol.
118
70-77
2006
Homo sapiens (P28039)
brenda
Shao, B.; Lu, M.; Katz, S.C.; Varley, A.W.; Hardwick, J.; Rogers, T.E.; Ojogun, N.; Rockey, D.C.; Dematteo, R.P.; Munford, R.S.
A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen
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282
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2007
Mus musculus (O35298)
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Gioannini, T.L.; Teghanemt, A.; Zhang, D.; Prohinar, P.; Levis, E.N.; Munford, R.S.; Weiss, J.P.
Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase
J. Biol. Chem.
282
7877-7884
2007
Homo sapiens
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Mehrzad, J.; Dosogne, H.; De Spiegeleer, B.; Duchateau, L.; Burvenich, C.
Bovine blood neutrophil acyloxyacyl hydrolase (AOAH) activity during endotoxin and coliform mastitis
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38
655-668
2007
Bos taurus (Q08DU1), Bos taurus
brenda
Lu, M.; Varley, A.W.; Ohta, S.; Hardwick, J.; Munford, R.S.
Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infection
Cell host microbe
4
293-302
2008
Mus musculus (O35298)
brenda
Ojogun, N.; Kuang, T.Y.; Shao, B.; Greaves, D.R.; Munford, R.S.; Varley, A.W.
Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo
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200
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Mus musculus
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Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin
Hepatology
54
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2011
Mus musculus
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Klaffenbach, D.; Friedrich, D.; Strick, R.; Strissel, P.L.; Beckmann, M.W.; Rascher, W.; Gessner, A.; Doetsch, J.; Meissner, U.; Schnare, M.
Contribution of different placental cells to the expression and stimulation of antimicrobial proteins (AMPs)
Placenta
32
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2011
Homo sapiens
brenda
Janelsins, B.M.; Lu, M.; Datta, S.K.
Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity
Proc. Natl. Acad. Sci. USA
111
373-378
2014
Mus musculus
brenda
Yang, W.; Yaggie, R.E.; Jiang, M.C.; Rudick, C.N.; Done, J.; Heckman, C.J.; Rosen, J.M.; Schaeffer, A.J.; Klumpp, D.J.
Acyloxyacyl hydrolase modulates pelvic pain severity
Am. J. Physiol. Regul. Integr. Comp. Physiol.
314
R353-R365
2018
Mus musculus (O35298), Mus musculus
brenda
Zou, B.; Jiang, W.; Han, H.; Li, J.; Mao, W.; Tang, Z.; Yang, Q.; Qian, G.; Qian, J.; Zeng, W.; Gu, J.; Chu, T.; Zhu, N.; Zhang, W.; Yan, D.; He, R.; Chu, Y.; Lu, M.
Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury
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13
e1006436
2017
Mus musculus (O35298), Mus musculus
brenda