BRENDA - Enzyme Database
show all sequences of 2.8.2.14

Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases

Senggunprai, L.; Yoshinari, K.; Yamazoe, Y.; Biochem. J. 422, 455-462 (2009)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
2,6-Dichloro-4-nitrophenol
non-specific SULT inhibitor
Homo sapiens
5,7-dichlorokynurenic acid
-
Homo sapiens
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Homo sapiens
Kynurenic acid
-
Homo sapiens
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Homo sapiens
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Homo sapiens
Mefenamic acid
-
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0014
-
dehydroepiandrosterone
isoform SULT2A1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3'-phosphoadenylyl sulfate + 1-naphthol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + desipramine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q06520
-
-
Purification (Commentary)
Commentary
Organism
Ni-NTA agarose column chromatography
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2,6-Dichloro-4-nitrophenol
non-specific SULT inhibitor
Homo sapiens
5,7-dichlorokynurenic acid
-
Homo sapiens
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Homo sapiens
Kynurenic acid
-
Homo sapiens
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Homo sapiens
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Homo sapiens
Mefenamic acid
-
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0014
-
dehydroepiandrosterone
isoform SULT2A1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3'-phosphoadenylyl sulfate + 1-naphthol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + desipramine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
Ni-NTA agarose column chromatography
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
Other publictions for EC 2.8.2.14
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
725821
Kurogi
A comparative study of the sul ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
127
307-314
2011
-
-
-
-
-
-
-
4
1
-
-
-
-
1
-
-
-
-
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8
-
10
-
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1
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4
1
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8
-
10
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
726539
Huang
Kinetic analysis of bile acid ...
Homo sapiens
Xenobiotica
40
184-194
2010
-
-
1
-
-
2
-
17
1
1
2
6
-
3
-
-
-
-
-
1
-
-
20
1
-
-
-
-
1
1
-
-
-
-
-
-
-
2
-
-
-
2
-
-
-
18
1
2
2
6
-
-
-
-
-
1
-
-
20
1
-
-
-
-
2
2
-
-
-
-
-
-
-
-
702138
Senggunprai
Inhibitory effects of kynureni ...
Homo sapiens
Biochem. J.
422
455-462
2009
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-
1
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-
7
1
1
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-
8
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1
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1
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1
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7
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1
1
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8
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1
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8
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-
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-
-
-
-
673838
Seo
Xenobiotic- and vitamin D-resp ...
Mus musculus
Gene
386
218-223
2007
2
1
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
1
-
-
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2
1
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-
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1
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-
1
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-
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-
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-
-
-
-
-
-
-
-
-
676007
Echchgadda
The xenobiotic-sensing nuclear ...
Homo sapiens
Mol. Endocrinol.
21
2099-2111
2007
2
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
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-
2
-
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-
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-
1
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-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660699
Chen
Fluorometric assay for alcohol ...
Homo sapiens
Anal. Biochem.
339
54-60
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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-
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-
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-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661602
Seely
Transcriptional regulation of ...
Homo sapiens
Endocrinology
146
3605-3613
2005
-
-
-
-
-
-
-
-
-
-
-
1
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2
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2
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1
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2
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-
-
662862
Stanley
Expression profiling of human ...
Homo sapiens
Mol. Cell. Endocrinol.
240
32-42
2005
-
-
-
-
-
-
-
-
1
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-
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1
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-
-
3
-
-
1
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1
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3
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-
1
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-
-
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-
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-
-
-
-
662913
Echchgadda
Dehydroepiandrosterone sulfotr ...
Homo sapiens, Rattus norvegicus
Mol. Pharmacol.
65
720-729
2004
-
-
2
-
-
-
-
-
-
-
-
2
-
6
-
-
-
-
-
-
-
-
2
-
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-
-
-
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-
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2
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2
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-
2
-
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-
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-
-
-
-
-
-
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-
-
-
-
645720
Macrides
Enzymic sulfation of bile salt ...
Heterodontus portusjacksoni
Comp. Biochem. Physiol. B
107
461-469
1994
-
-
-
-
-
-
2
2
1
-
1
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
2
1
-
1
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
645721
Obinata
Bile salt sulphotransferase ac ...
Homo sapiens
Scand. J. Clin. Lab. Invest.
54
285-290
1994
-
-
-
-
-
-
-
2
1
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-
-
-
1
-
-
-
-
-
1
-
-
4
-
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2
1
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1
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4
-
-
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-
-
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-
-
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-
645718
Obinata
The effect of essential fatty ...
Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
42
625-627
1992
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-
-
-
-
-
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1
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1
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1
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-
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-
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-
-
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-
-
645719
Singer
Fatty acid binding protein inh ...
Rattus norvegicus
Biochem. Int.
27
373-383
1992
-
-
-
-
-
-
-
-
1
-
-
1
-
1
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1
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3
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1
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1
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1
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3
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645717
Kane
Hepatic bile salt sulfotransfe ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
J. Ped. Gastroent. Nutri.
12
260-268
1991
1
-
-
-
-
-
4
-
1
2
-
2
-
163
-
-
1
-
-
1
-
-
14
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
4
1
-
1
2
-
2
-
-
-
1
-
1
-
-
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645716
Barnes
Evidence for an ordered reacti ...
Macaca mulatta
J. Lipid Res.
27
1111-1123
1986
-
-
-
-
-
-
1
-
1
1
1
-
-
2
-
-
1
-
-
1
-
-
1
-
-
-
-
-
1
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-
1
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1
1
1
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1
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1
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1
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-
1
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645715
Chen
Purification and characterizat ...
Homo sapiens
Arch. Biochem. Biophys.
241
371-379
1985
-
-
-
-
-
-
4
6
1
-
3
-
-
1
-
-
1
-
-
1
1
-
5
-
-
-
-
-
1
1
-
-
3
1
-
-
-
-
-
-
-
-
-
4
3
6
1
-
3
-
-
-
-
1
-
1
1
-
5
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
645713
Barnes
Evidence for heterogeneity of ...
Mesocricetus auratus, Rattus norvegicus, Rattus norvegicus Wistar
Biochim. Biophys. Acta
704
353-360
1982
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-
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2
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6
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-
167
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2
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1
6
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-
-
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2
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6
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2
-
1
6
-
-
-
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-
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-
645714
Chen
Bile salt sulfotransferase in ...
Cavia porcellus
Biochim. Biophys. Acta
717
316-321
1982
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-
-
-
-
1
9
2
-
8
1
1
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1
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1
-
-
2
1
2
11
-
-
-
-
-
1
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-
-
-
1
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-
-
-
-
-
-
1
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9
-
2
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8
1
1
-
-
-
1
-
2
1
2
11
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
645712
Chen
Bile salt sulfotransferase ...
Cavia porcellus, Homo sapiens, Mesocricetus auratus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Methods Enzymol.
77
213-218
1981
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18
2
3
6
1
2
-
6
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1
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9
1
1
12
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1
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-
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-
-
-
18
-
2
3
6
1
2
-
-
-
1
-
9
1
1
12
-
-
-
-
-
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1
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-
645711
Loeoef
Partial purification of a huma ...
Homo sapiens
Biochim. Biophys. Acta
617
192-204
1980
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-
-
-
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1
3
2
1
3
-
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1
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1
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1
1
2
7
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1
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1
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1
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3
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2
1
3
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1
-
1
1
2
7
-
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1
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1
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-
645709
Chen
Enzymatic sulfation of bile sa ...
Rattus norvegicus
Biochim. Biophys. Acta
522
443-451
1978
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-
-
-
-
-
9
3
1
-
1
1
-
1
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-
1
-
-
2
1
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11
-
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1
2
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-
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9
1
3
1
-
1
1
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-
1
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2
1
-
11
-
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-
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-
2
-
-
-
-
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-
645710
Loeoef
Enzymatic sulphation of bile s ...
Homo sapiens
Biochim. Biophys. Acta
530
451-460
1978
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1
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2
2
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1
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2
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2
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1
1
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1
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2
2
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2
-
-
2
-
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-
1
1
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-
-
-
-
645708
Chen
Enzymatic sulfation of bile sa ...
Rattus norvegicus
Biochim. Biophys. Acta
480
219-227
1977
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-
-
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-
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3
2
1
1
1
1
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1
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1
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3
-
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3
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1
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1
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3
-
2
1
1
1
1
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1
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3
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3
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1
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1
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