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Information on EC 2.8.2.14 - bile-salt sulfotransferase

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.2 Sulfotransferases
                2.8.2.14 bile-salt sulfotransferase
IUBMB Comments
The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species . This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5beta-bile acid glycolithocholate, deoxycholate, 3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2 .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
3'-phosphoadenylyl-sulfate:taurolithocholate sulfotransferase, 3beta-hydroxy-5-cholenoate sulfotransferase, BAST, BAST I, bile acid sulfotransferase I, bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase, bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase, BSS, BSS I, BSS II, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
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3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate
show the reaction diagram
both conjugated and unconjugated bile salts can act as acceptors
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PATHWAY SOURCE
PATHWAYS
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