Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.86 extracted from

  • Sharma, M.; Rajendrarao, S.; Shahani, N.; Ramirez-Jarquin, U.N.; Subramaniam, S.
    Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease (2020), Proc. Natl. Acad. Sci. USA, 117, 15989-15999 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.86

Application

Application Comment Organism
medicine the enzyme is a target for treatment of Huntigton disease Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GTP Homo sapiens overall reaction 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?
ATP + GTP Mus musculus overall reaction 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?
ATP + GTP Mus musculus C57BL/6J overall reaction 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N884
-
-
Mus musculus Q8C6L5
-
-
Mus musculus C57BL/6J Q8C6L5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
corpus striatum
-
 Homo sapiens
-
striatal neuron
-
 Homo sapiens
-
striatal neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GTP overall reaction Homo sapiens 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?
ATP + GTP overall reaction Mus musculus 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?
ATP + GTP overall reaction Mus musculus C57BL/6J 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?

Synonyms

Synonyms Comment Organism
cGAS
-
 Homo sapiens
cGAS
-
 Mus musculus

General Information

General Information Comment Organism
malfunction depletion of cGAS diminishes cGAS activity and decreases the expression of inflammatory genes while suppressing the upregulation of autophagy in Huntington disease (HD) cells, while reinstating cGAS in cGAS-depleted HD cells activates cGAS activity and promotes inflammatory and autophagy responses. Phenotype, overview Homo sapiens
malfunction depletion of cGAS diminishes cGAS activity and decreases the expression of inflammatory genes while suppressing the upregulation of autophagy in Huntington disease (HD) cells, while reinstating cGAS in cGAS-depleted HD cells activates cGAS activity and promotes inflammatory and autophagy responses. Phenotype, overview Mus musculus
physiological function cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease (HD). cGMP-AMP synthase (cGAS), a DNA sensor, is a critical regulator of inflammatory and autophagy responses in HD. Ribosome profiling reveals that the cGAS mRNA has high ribosome occupancy at exon 1 and codon-specific pauses at positions 171 (CCG) and 172 (CGT) in HD striatal cells. The protein levels and activity of cGAS (based on the phosphorylated STING and phosphorylated TBK1 levels), and the expression and ribosome occupancy of cGAS-dependent inflammatory genes (Ccl5 and Cxcl10) are increased in HD striatum. Phenotype, overview Mus musculus
physiological function cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease (HD). cGMP-AMP synthase (cGAS), a DNA sensor, is a critical regulator of inflammatory and autophagy responses in HD. Ribosome profiling reveals that the cGAS mRNA has high ribosome occupancy at exon 1 and codon-specific pauses at positions 171 (CCG) and 172 (CGT) in HD striatal cells. The protein levels and activity of cGAS (based on the phosphorylated STING and phosphorylated TBK1 levels), and the expression and ribosome occupancy of cGAS-dependent inflammatory genes (Ccl5 and Cxcl10) are increased in HD striatum. The two major autophagy initiators, LC3A and LC3B, may be differentially regulated via cotranslational proteolytic events to initiate autophagy, which might additionally contribute to the cGAS-mediated autophagy in HD. Phenotype, overview Homo sapiens