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Information on EC 2.7.7.86 - cyclic GMP-AMP synthase

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.86 cyclic GMP-AMP synthase
IUBMB Comments
Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
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Word Map
  • 2.7.7.86
  • sting
  • antiviral
  • cgas-sting
  • dsdna
  • sting-dependent
  • dna-sensing
  • cgas-dependent
  • cgas-mediated
  • dna-induced
  • tank-binding
  • dna-triggered
  • self-dna
  • medicine
  • monophosphate-adenosine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
cGAMP synthase, cGAS, cyclic GMP-AMP synthase, MB21D1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + GTP = 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
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overall reaction
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ATP + GTP = pppGp(2'-5')A + diphosphate
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(1a)
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pppGp(2'-5')A = cyclic Gp(2'-5')Ap(3'-5') + diphosphate
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(1b)
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