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Literature summary for 2.7.7.49 extracted from
- Drug resistance-associated genotypic alterations in the pol gene of HIV type 1 isolates in ART-naive individuals in North India (2008), AIDS Res. Hum. Retroviruses, 24, 125-130.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G190V | mutant with high level of resistance to efavirenz and nevirapine | Human immunodeficiency virus 1 |
| K101R | non-nucleoside reverse transcriptase inhibitor resistance mutation | Human immunodeficiency virus 1 |
| K103R | non-nucleoside reverse transcriptase inhibitor resistance mutation | Human immunodeficiency virus 1 |
| M230D | non-nucleoside reverse transcriptase inhibitor resistance mutation | Human immunodeficiency virus 1 |
| M230N | non-nucleoside reverse transcriptase inhibitor resistance mutation | Human immunodeficiency virus 1 |
| V197I | non-nucleoside reverse transcriptase inhibitor resistance mutation | Human immunodeficiency virus 1 |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| efavirenz | - |
Human immunodeficiency virus 1 |  |
| nevirapine | - |
Human immunodeficiency virus 1 | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 1 | O12158 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | - |
Human immunodeficiency virus 1 | diphosphate + DNAn+1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pol | - |
Human immunodeficiency virus 1 |
| reverse transcriptase | - |
Human immunodeficiency virus 1 |
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