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Information on EC 2.7.7.49 - RNA-directed DNA polymerase

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IUBMB Comments
Catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template. See also EC 2.7.7.7 DNA-directed DNA polymerase.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
telomerase, reverse-transcriptase, telomerase reverse transcriptase, nucleoside reverse transcriptase, hiv-1 rt, hiv-1 reverse transcriptase, gag-pol, hiv reverse transcriptase, rna-dependent dna polymerase, telomerase catalytic subunit, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1
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