Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-oxoisopentanoate | - |
Bos taurus | |
acetoacetyl-CoA | slight activation | Bos taurus | |
acetyl-CoA | synergism with NADH | Bos taurus | |
benzoyl-CoA | slight activation | Bos taurus | |
L-methylmalonyl-CoA | slight activation | Bos taurus | |
malonyl-CoA | - |
Bos taurus | |
NADH | activation, in the presence of K+ | Bos taurus | |
propionyl-CoA | slight activation at low concentrations, synergism with NADH plus NAD+ | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
butyryl-CoA | at high concentrations | Bos taurus | |
decanoyl-CoA | - |
Bos taurus | |
hexanoyl-CoA | - |
Bos taurus | |
linolenoyl-CoA | - |
Bos taurus | |
linoleoyl-CoA | - |
Bos taurus | |
additional information | no inhibition by succinyl-CoA, tiglyl-CoA, crotonyl-CoA, glutaryl-CoA, DL-3-hydroxy-3-methylglutaryl-CoA, acetylcarnitine or 3-hydroxybutyryl-CoA | Bos taurus | |
myristoyl-CoA | - |
Bos taurus | |
oleoyl-CoA | - |
Bos taurus | |
stearoyl-CoA | - |
Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [pyruvate dehydrogenase (lipoamide)] | Bos taurus | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [pyruvate dehydrogenase (lipoamide)] | - |
Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
ATP + [pyruvate dehydrogenase (lipoamide)] | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.3 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | dependent on | Bos taurus | |
additional information | no activation by succinyl-CoA, tiglyl-CoA, crotonyl-CoA, glutaryl-CoA, DL-3-hydroxy-3-methylglutaryl-CoA, acetylcarnitine or 3-hydroxybutyryl-CoA | Bos taurus |