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Literature summary for 2.7.11.12 extracted from

  • Gambaryan, S.; Butt, E.; Marcus, K.; Glazova, M.; Palmetshofer, A.; Guillon, G.; Smolenski, A.
    cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene (2003), J. Biol. Chem., 278, 29640-29648.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
8-pCPT-CGMP i.e. 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate Rattus norvegicus
cGMP
-
 Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
K482A site-directed mutagenesis, transfection of the catalytically inactive PKGII mutant inhibits aldosterone production in zona glomerulosa cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information PKGII inhibition inhibits aldosterone production Rattus norvegicus
Rp-8-p-CPT-cGMP i.e. Rp-8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus PKGII regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland cortex, PKGI Rattus norvegicus
-
blood vessel PKGI Rattus norvegicus
-
zona glomerulosa adrenal, PKGI, expression of PKGII is restricted to adrenal zona glomerulosa cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + steroidogenic acute regulatory protein i.e. StAR, recombinant GST-tagged substrate expressed in HEK-293 cells, phosphorylation in vitro at Ser55, Ser56, and Ser99 Rattus norvegicus ADP + phosphorylated steroidogenic acute regulatory protein
-
 ?
additional information PKGII regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
cGMP-dependent protein kinase type II
-
 Rattus norvegicus
PKG II
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus