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Information on EC 2.7.11.12 - cGMP-dependent protein kinase

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IUBMB Comments
CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates . The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase .
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
CGK, CGK 1 alpha, CGK 1 beta, cGK I, cGK II, cGK-I, cGK-II, cGKI, cGKI alpha, cGKI beta, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
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