Activating Compound | Comment | Organism | Structure |
---|---|---|---|
heregulin | induces phosphorylation of ErbB3 and metastatic properties including MMP-9 expression, invasion, adhesion and experimental lung metastasis in vivo | Mus musculus | |
heregulin | rapidly induces phosphorylation of EGFR | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | heregulin-induced activation of ErbB3 via EGFR (EGFR is a possible heterodimeric counterpart of ErbB3) promotes tumor growth and metastasis of melanoma cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PD153035 | inhibits tyrosine kinase activity of EGFR and whereby blocks cellular responses of activated ErbB3. It inhibits heregulin-induced VEGFA expression; inhibits tyrosine kinase activity of EGFR and whereby blocks cellular responses of activated ErbB3. It inhibits heregulin-induced VEGFA expression | Mus musculus | |
shRNA | sh-ErbB3 cells normally metastasize to the lung, but the heregulin-induced increase in metastasis is completely abrogated. Inactivation of ErbB3 by shRNA does not directly influence the formation of metastatic colonies in the experimental metastasis model, although heregulin-induced enhancement is completely dependent on ErbB3. However, spontaneous metastasis by inoculating the cells without heregulin stimulation into the foot pad is significantly decreased | Mus musculus | |
siRNA | local injection of siRNA against ErbB3 with the atolocollagen results in a decrease in the tumor growth of parent B16-BL6 cells | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q01279 | - |
- |
Mus musculus | Q61526 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B16-BL6 cell | overexpression of functional ErbB3 | Mus musculus | - |
additional information | overexpression of EGFR in CBO140C12 cells | Mus musculus | - |
additional information | overexpression of ErbB2, but not ErbB3 in CBO140C12 cells | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Egfr | - |
Mus musculus |
ErbB2 | - |
Mus musculus |
ErbB3 | - |
Mus musculus |
ErbB3 receptor tyrosine kinase | - |
Mus musculus |