Application | Comment | Organism |
---|---|---|
drug development | series of indenopyrazoles designed and synthesized as EGFR tyrosine kinase inhibitors by in silico highthroughput screening | Homo sapiens |
drug development | series of indenopyrazoles designed and synthesized as KDR inhibitors by in silico highthroughput screening | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
EGFR tyrosine kinase domain in complex with erlotinib | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-aminophenyl)-3-[3-(1,3-benzodioxol-5-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]urea | 61% inhibition of EGFR; 88% inhibition of KDR | Homo sapiens | |
1-(4-aminophenyl)-3-[3-(3,4-dihydroxyphenyl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]urea | 50% inhibition of EGFR; 58% inhibition of KDR | Homo sapiens | |
1-(4-aminophenyl)-3-[3-(4-hydroxyphenyl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]urea | 65% inhibition of EGFR; 73% inhibition of KDR | Homo sapiens | |
1-(4-aminophenyl)-3-[3-(4-methoxyphenyl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]urea | 3% inhibition of EGFR; 42% inhibition of KDR | Homo sapiens | |
1-(4-hydroxyphenyl)-3-[3-(4-methoxyphenyl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]urea | 44% inhibition of KDR; 7% inhibition of EGFR | Homo sapiens | |
1-[3-(1,3-benzodioxol-5-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]-3-(4-hydroxyphenyl)urea | 4% inhibition of EGFR; 70% inhibition of KDR | Homo sapiens | |
AAL 993 | 30% inhibition of EGFR; 95% inhibition of KDR | Homo sapiens | |
erlotinib | - |
Homo sapiens | |
Tarceva | 38% inhibition of KDR; 81% inhibition of EGFR | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00533 | - |
- |
Homo sapiens | P35968 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-431 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
EGFR tyrosine kinase | - |
Homo sapiens |
erb-B1 | - |
Homo sapiens |
HER-1 | - |
Homo sapiens |
KDR | - |
Homo sapiens |
VEGFR-2 tyrosine kinase | - |
Homo sapiens |