BRENDA - Enzyme Database
show all sequences of 2.7.1.127

Inositol(1,4,5)P3 3-kinase isoenzymes: catalytic properties and importance of targeting to F-actin to understand function

Erneux, C.; Ghosh, S.; Koenig, S.; Adv. Biol. Regul. 60, 135-143 (2016)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
Calmodulin
the enzyme is activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain
Homo sapiens
Calmodulin
the enzyme is activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain
Rattus norvegicus
Calmodulin
the enzyme is activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain
Mus musculus
Calmodulin
the enzyme is highly activated by Ca2+/calmodulin, ten to twentyfold increase in activity in human platelets. The isozyme contains a CaM binding domain
Homo sapiens
Calmodulin
the enzyme is highly activated by Ca2+/calmodulin, two or threefold in rat brain. The isozyme contains a CaM binding domain
Rattus norvegicus
Calmodulin
the enzyme is highly activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain
Mus musculus
Carbachol
activates the enzyme up to 7fold in rat brain cortical slices
Rattus norvegicus
additional information
phosphorylation activates the activity of isozyme Itpka
Rattus norvegicus
additional information
the enzyme is stimulated by purinergic agonists in human astrocytoma cells
Homo sapiens
Cloned(Commentary)
Cloned (Commentary)
Organism
gene Itpka
Homo sapiens
gene Itpka
Rattus norvegicus
gene Itpka
Mus musculus
gene Itpkb
Rattus norvegicus
gene Itpkb
Homo sapiens
gene Itpkb
Mus musculus
gene Itpkc
Rattus norvegicus
gene Itpkc
Mus musculus
gene Itpkc
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoskeleton
cytoskeletal localization for isozyme Itpka
Homo sapiens
5856
-
cytoskeleton
cytoskeletal localization for isozyme Itpka
Rattus norvegicus
5856
-
cytoskeleton
cytoskeletal localization for isozyme Itpka
Mus musculus
5856
-
cytoskeleton
cytoskeletal localization for isozyme Itpkb or at the leading edge for Itpkb
Rattus norvegicus
5856
-
cytoskeleton
cytoskeletal localization for isozyme Itpkb or at the leading edge for Itpkb
Homo sapiens
5856
-
cytoskeleton
cytoskeletal localization for isozyme Itpkb or at the leading edge for Itpkb
Mus musculus
5856
-
endoplasmic reticulum
-
Rattus norvegicus
5783
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
the enzyme is activated by Ca2+/calmodulin
Homo sapiens
Ca2+
the enzyme is activated by Ca2+/calmodulin
Rattus norvegicus
Ca2+
the enzyme is activated by Ca2+/calmodulin
Mus musculus
Ca2+
the enzyme is highly activated by Ca2+/calmodulin
Rattus norvegicus
Ca2+
the enzyme is highly activated by Ca2+/calmodulin
Homo sapiens
Ca2+
the enzyme is highly activated by Ca2+/calmodulin
Mus musculus
Mg2+
required
Rattus norvegicus
Mg2+
required
Homo sapiens
Mg2+
required
Mus musculus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
50000
-
-
Homo sapiens
50000
-
-
Rattus norvegicus
50000
-
-
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Rattus norvegicus
-
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Homo sapiens
-
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Mus musculus
-
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
P23677
gene Itpka
-
Homo sapiens
P27987
gene Itpkb
-
Homo sapiens
Q96DU7
gene Itpkc
-
Mus musculus
B2RXC2
gene Itpkb
-
Mus musculus
Q7TS72
gene Itpkc
-
Mus musculus
Q8R071
gene Itpka
-
Rattus norvegicus
P17105
gene Itpka
-
Rattus norvegicus
P42335
gene Itpkb
-
Rattus norvegicus
Q80ZG2
gene Itpkc
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
phosphoprotein
phosphorylation activates the activity of isozyme Itpka
Rattus norvegicus
proteolytic modification
Itpka undergoes proteolysis in intact cells, leading to the accumulation of a stable C-terminal domain of 83 kDa to the endoplasmic reticulum, incubation of Itpka at 37°C for 30 min totally destroys Ins(1,4,5)P3 3-kinase activity unless the enzyme is mixed with 0.1% SDS
Rattus norvegicus
proteolytic modification
Itpkb is very sensitive to proteolysis
Rattus norvegicus
proteolytic modification
Itpkb is very sensitive to proteolysis
Homo sapiens
proteolytic modification
Itpkb is very sensitive to proteolysis
Mus musculus
Purification (Commentary)
Purification (Commentary)
Organism
elution of recombinant Itpka isozyme with 0.5% SDS and 0.1 mM EGTA from calmodulin affinity column
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
astrocytoma cell
-
Homo sapiens
-
blood platelet
-
Rattus norvegicus
-
blood platelet
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
Itpka is particularly active in neurons of the hippocampus and cerebellum
Homo sapiens
-
brain
Itpka is particularly active in neurons of the hippocampus and cerebellum
Rattus norvegicus
-
brain
Itpka is particularly active in neurons of the hippocampus and cerebellum
Mus musculus
-
brain
Itpkb protein level is increased in the cerebral cortex of most patients with Alzheimer's disease compared with control subjects
Homo sapiens
-
carcinoma cell
-
Rattus norvegicus
-
carcinoma cell
-
Homo sapiens
-
carcinoma cell
-
Mus musculus
-
embryonic stem cell
Itpkb protein level is increased upon differentiation of human embryonic stem cells
Homo sapiens
-
hippocampus
dendritic spines
Rattus norvegicus
-
intestine
-
Rattus norvegicus
-
intestine
-
Homo sapiens
-
intestine
-
Mus musculus
-
additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
Homo sapiens
-
additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
Rattus norvegicus
-
additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
Mus musculus
-
additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
Rattus norvegicus
-
additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
Homo sapiens
-
additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
Mus musculus
-
neuron
localized to the post-dendritic spines of neurons. Itpka is particularly active in neurons of the hippocampus and cerebellum
Homo sapiens
-
neuron
localized to the post-dendritic spines of neurons. Itpka is particularly active in neurons of the hippocampus and cerebellum
Rattus norvegicus
-
neuron
localized to the post-dendritic spines of neurons. Itpka is particularly active in neurons of the hippocampus and cerebellum
Mus musculus
-
PC-12 cell
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-
testis
-
Homo sapiens
-
testis
-
Mus musculus
-
testis
high expression level
Rattus norvegicus
-
thymus
-
Rattus norvegicus
-
thymus
-
Homo sapiens
-
thymus
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
737402
Rattus norvegicus
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
737402
Homo sapiens
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
737402
Mus musculus
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 50000, isozyme Itpka from rat brain, SDS-PAGE
Rattus norvegicus
?
x * 50000, isozyme Itpka, SDS-PAGE
Homo sapiens
?
x * 50000, isozyme Itpka, SDS-PAGE
Mus musculus
More
isozyme Itpka contains an F-actin binding site at the N-terminal part
Homo sapiens
More
isozyme Itpka contains an F-actin binding site at the N-terminal part
Rattus norvegicus
More
isozyme Itpka contains an F-actin binding site at the N-terminal part
Mus musculus
More
isozyme Itpkb contains an F-actin binding site at the N-terminal part
Rattus norvegicus
More
isozyme Itpkb contains an F-actin binding site at the N-terminal part
Homo sapiens
More
isozyme Itpkb contains an F-actin binding site at the N-terminal part
Mus musculus
Synonyms
Synonyms
Commentary
Organism
inositol(1,4,5)P3 3-kinase
-
Rattus norvegicus
inositol(1,4,5)P3 3-kinase
-
Homo sapiens
inositol(1,4,5)P3 3-kinase
-
Mus musculus
inositol(1,4,5)trisphosphate 3-kinase
-
Mus musculus
inositol(1,4,5)trisphosphate 3-kinases
-
Rattus norvegicus
inositol(1,4,5)trisphosphate 3-kinases
-
Homo sapiens
ITPKA
-
Homo sapiens
ITPKA
-
Rattus norvegicus
ITPKA
-
Mus musculus
Itpkb
-
Rattus norvegicus
Itpkb
-
Homo sapiens
Itpkb
-
Mus musculus
Itpkc
-
Rattus norvegicus
Itpkc
-
Mus musculus
Itpkc
-
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Rattus norvegicus
ATP
-
Homo sapiens
ATP
-
Mus musculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
Calmodulin
the enzyme is activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain
Homo sapiens
Calmodulin
the enzyme is activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain
Rattus norvegicus
Calmodulin
the enzyme is activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain
Mus musculus
Calmodulin
the enzyme is highly activated by Ca2+/calmodulin, ten to twentyfold increase in activity in human platelets. The isozyme contains a CaM binding domain
Homo sapiens
Calmodulin
the enzyme is highly activated by Ca2+/calmodulin, two or threefold in rat brain. The isozyme contains a CaM binding domain
Rattus norvegicus
Calmodulin
the enzyme is highly activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain
Mus musculus
Carbachol
activates the enzyme up to 7fold in rat brain cortical slices
Rattus norvegicus
additional information
phosphorylation activates the activity of isozyme Itpka
Rattus norvegicus
additional information
the enzyme is stimulated by purinergic agonists in human astrocytoma cells
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
gene Itpka
Homo sapiens
gene Itpka
Rattus norvegicus
gene Itpka
Mus musculus
gene Itpkb
Rattus norvegicus
gene Itpkb
Homo sapiens
gene Itpkb
Mus musculus
gene Itpkc
Rattus norvegicus
gene Itpkc
Mus musculus
gene Itpkc
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Rattus norvegicus
ATP
-
Homo sapiens
ATP
-
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoskeleton
cytoskeletal localization for isozyme Itpka
Homo sapiens
5856
-
cytoskeleton
cytoskeletal localization for isozyme Itpka
Rattus norvegicus
5856
-
cytoskeleton
cytoskeletal localization for isozyme Itpka
Mus musculus
5856
-
cytoskeleton
cytoskeletal localization for isozyme Itpkb or at the leading edge for Itpkb
Rattus norvegicus
5856
-
cytoskeleton
cytoskeletal localization for isozyme Itpkb or at the leading edge for Itpkb
Homo sapiens
5856
-
cytoskeleton
cytoskeletal localization for isozyme Itpkb or at the leading edge for Itpkb
Mus musculus
5856
-
endoplasmic reticulum
-
Rattus norvegicus
5783
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
the enzyme is activated by Ca2+/calmodulin
Homo sapiens
Ca2+
the enzyme is activated by Ca2+/calmodulin
Rattus norvegicus
Ca2+
the enzyme is activated by Ca2+/calmodulin
Mus musculus
Ca2+
the enzyme is highly activated by Ca2+/calmodulin
Rattus norvegicus
Ca2+
the enzyme is highly activated by Ca2+/calmodulin
Homo sapiens
Ca2+
the enzyme is highly activated by Ca2+/calmodulin
Mus musculus
Mg2+
required
Rattus norvegicus
Mg2+
required
Homo sapiens
Mg2+
required
Mus musculus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
50000
-
-
Homo sapiens
50000
-
-
Rattus norvegicus
50000
-
-
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Rattus norvegicus
-
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Homo sapiens
-
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Mus musculus
-
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
phosphoprotein
phosphorylation activates the activity of isozyme Itpka
Rattus norvegicus
proteolytic modification
Itpka undergoes proteolysis in intact cells, leading to the accumulation of a stable C-terminal domain of 83 kDa to the endoplasmic reticulum, incubation of Itpka at 37°C for 30 min totally destroys Ins(1,4,5)P3 3-kinase activity unless the enzyme is mixed with 0.1% SDS
Rattus norvegicus
proteolytic modification
Itpkb is very sensitive to proteolysis
Rattus norvegicus
proteolytic modification
Itpkb is very sensitive to proteolysis
Homo sapiens
proteolytic modification
Itpkb is very sensitive to proteolysis
Mus musculus
Purification (Commentary) (protein specific)
Commentary
Organism
elution of recombinant Itpka isozyme with 0.5% SDS and 0.1 mM EGTA from calmodulin affinity column
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
astrocytoma cell
-
Homo sapiens
-
blood platelet
-
Rattus norvegicus
-
blood platelet
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
Itpka is particularly active in neurons of the hippocampus and cerebellum
Homo sapiens
-
brain
Itpka is particularly active in neurons of the hippocampus and cerebellum
Rattus norvegicus
-
brain
Itpka is particularly active in neurons of the hippocampus and cerebellum
Mus musculus
-
brain
Itpkb protein level is increased in the cerebral cortex of most patients with Alzheimer's disease compared with control subjects
Homo sapiens
-
carcinoma cell
-
Rattus norvegicus
-
carcinoma cell
-
Homo sapiens
-
carcinoma cell
-
Mus musculus
-
embryonic stem cell
Itpkb protein level is increased upon differentiation of human embryonic stem cells
Homo sapiens
-
hippocampus
dendritic spines
Rattus norvegicus
-
intestine
-
Rattus norvegicus
-
intestine
-
Homo sapiens
-
intestine
-
Mus musculus
-
additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
Homo sapiens
-
additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
Rattus norvegicus
-
additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
Mus musculus
-
additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
Rattus norvegicus
-
additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
Homo sapiens
-
additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
Mus musculus
-
neuron
localized to the post-dendritic spines of neurons. Itpka is particularly active in neurons of the hippocampus and cerebellum
Homo sapiens
-
neuron
localized to the post-dendritic spines of neurons. Itpka is particularly active in neurons of the hippocampus and cerebellum
Rattus norvegicus
-
neuron
localized to the post-dendritic spines of neurons. Itpka is particularly active in neurons of the hippocampus and cerebellum
Mus musculus
-
PC-12 cell
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-
testis
-
Homo sapiens
-
testis
-
Mus musculus
-
testis
high expression level
Rattus norvegicus
-
thymus
-
Rattus norvegicus
-
thymus
-
Homo sapiens
-
thymus
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
737402
Rattus norvegicus
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
737402
Homo sapiens
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
737402
Mus musculus
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 50000, isozyme Itpka from rat brain, SDS-PAGE
Rattus norvegicus
?
x * 50000, isozyme Itpka, SDS-PAGE
Homo sapiens
?
x * 50000, isozyme Itpka, SDS-PAGE
Mus musculus
More
isozyme Itpka contains an F-actin binding site at the N-terminal part
Homo sapiens
More
isozyme Itpka contains an F-actin binding site at the N-terminal part
Rattus norvegicus
More
isozyme Itpka contains an F-actin binding site at the N-terminal part
Mus musculus
More
isozyme Itpkb contains an F-actin binding site at the N-terminal part
Rattus norvegicus
More
isozyme Itpkb contains an F-actin binding site at the N-terminal part
Homo sapiens
More
isozyme Itpkb contains an F-actin binding site at the N-terminal part
Mus musculus
General Information
General Information
Commentary
Organism
evolution
inositol(1,4,5)trisphosphate 3-kinases (Itpks) occur in three isoenzyme forms, Itpka/b and c, in human, rat and mouse. They share a catalytic domain relatively well conserved at the C-terminal end and a quite isoenzyme specific regulatory domain at the N-terminal end of the protein
Rattus norvegicus
evolution
inositol(1,4,5)trisphosphate 3-kinases (Itpks) occur in three isoenzyme forms, Itpka/b and c, in human, rat and mouse. They share a catalytic domain relatively well conserved at the C-terminal end and a quite isoenzyme specific regulatory domain at the N-terminal end of the protein
Homo sapiens
evolution
inositol(1,4,5)trisphosphate 3-kinases (Itpks) occur in three isoenzyme forms, Itpka/b and c, in human, rat and mouse. They share a catalytic domain relatively well conserved at the C-terminal end and a quite isoenzyme specific regulatory domain at the N-terminal end of the protein
Mus musculus
malfunction
isozyme Itpka-deficient mice exhibit increased LTP in the CA1 region of the hippocampus
Mus musculus
malfunction
mice deficient for Itpkb have a severe defect in thymocytes differentiation and thus lack peripheral T cells
Mus musculus
metabolism
1D-myo-inositol 1,3,4,5-tetrakisphosphate, Ins(1,3,4,5)P4 can interact with a relatively specific Ins(1,3,4,5)P4 binding protein Rasa3, alternatively, Ins(1,3,4,5)P4 can also compete with phosphoinositides to the binding of PH domain containing proteins such as Akt, protein kinase B. In neutrophils and hematopoietic progenitors, elevated levels of Ins(1,3,4,5)P4 inhibit the recruitment of Akt at the plasma membrane, and its activation, acting as a competitor of PtdIns(3,4,5)P3 binding to its PH domain
Rattus norvegicus
metabolism
1D-myo-inositol 1,3,4,5-tetrakisphosphate, Ins(1,3,4,5)P4 can interact with a relatively specific Ins(1,3,4,5)P4 binding protein Rasa3, alternatively, Ins(1,3,4,5)P4 can also compete with phosphoinositides to the binding of PH domain containing proteins such as Akt, protein kinase B. In neutrophils and hematopoietic progenitors, elevated levels of Ins(1,3,4,5)P4 inhibit the recruitment of Akt at the plasma membrane, and its activation, acting as a competitor of PtdIns(3,4,5)P3 binding to its PH domain
Homo sapiens
metabolism
1D-myo-inositol 1,3,4,5-tetrakisphosphate, Ins(1,3,4,5)P4 can interact with a relatively specific Ins(1,3,4,5)P4 binding protein Rasa3, alternatively, Ins(1,3,4,5)P4 can also compete with phosphoinositides to the binding of PH domain containing proteins such as Akt, protein kinase B. In neutrophils and hematopoietic progenitors, elevated levels of Ins(1,3,4,5)P4 inhibit the recruitment of Akt at the plasma membrane, and its activation, acting as a competitor of PtdIns(3,4,5)P3 binding to its PH domain
Mus musculus
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
Rattus norvegicus
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
Homo sapiens
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
Mus musculus
additional information
ITPKC functional polymorphism associates with Kawasaki disease susceptibility
Homo sapiens
physiological function
in natural killer (NK) cells, isozyme Itpkb promotes NK-cell terminal maturation but limits NK-cell effector functions
Homo sapiens
physiological function
in natural killer (NK) cells, isozyme Itpkb promotes NK-cell terminal maturation but limits NK-cell effector functions. Itpka and Itpkb isoforms inhibit neurite outgrowth in PC12 cells, while isozyme Itpkc does not
Rattus norvegicus
physiological function
in natural killer (NK) cells, isozyme Itpkb promotes NK-cell terminal maturation but limits NK-cell effector functions. Itpkb controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice
Mus musculus
physiological function
isozyme Itpka contains an F-actin binding site at the N-terminal part that confers to Itpka the properties of an F-actin bundling protein with two major consequences: it can reorganize the cytoskeletal network, particularly in dendritic spines, and it can provide an opportunity for Ins(1,3,4,5)P4 to act very locally as second messenger. Isozyme Itpka is an F-actin bundling protein regulating dendritic spines structural plasticity and a scaffold protein for synaptic rac signaling, Itpka overexpression induces cytoskeletal reorganization, high expression of Itpka in cancer cells increases invasion and migration in vitro
Homo sapiens
physiological function
isozyme Itpka contains an F-actin binding site at the N-terminal part that confers to Itpka the properties of an F-actin bundling protein with two major consequences: it can reorganize the cytoskeletal network, particularly in dendritic spines, and it can provide an opportunity for Ins(1,3,4,5)P4 to act very locally as second messenger. Isozyme Itpka is an F-actin bundling protein regulating dendritic spines structural plasticity and a scaffold protein for synaptic rac signaling, Itpka overexpression induces cytoskeletal reorganization, high expression of Itpka in cancer cells increases invasion and migration in vitro
Mus musculus
physiological function
isozyme Itpka contains an F-actin binding site at the N-terminal part that confers to Itpka the properties of an F-actin bundling protein with two major consequences: it can reorganize the cytoskeletal network, particularly in dendritic spines, and it can provide an opportunity for Ins(1,3,4,5)P4 to act very locally as second messenger. Isozyme Itpka is an F-actin bundling protein regulating dendritic spines structural plasticity and a scaffold protein for synaptic rac signaling, Itpka overexpression induces cytoskeletal reorganization, high expression of Itpka in cancer cells increases invasion and migration in vitro. Itpka and Itpkb isoforms inhibit neurite outgrowth in PC12 cells, while isozyme Itpkc does not
Rattus norvegicus
physiological function
Itpka and Itpkb isoforms inhibit neurite outgrowth in PC12 cells, while isozyme Itpkc does not
Rattus norvegicus
General Information (protein specific)
General Information
Commentary
Organism
evolution
inositol(1,4,5)trisphosphate 3-kinases (Itpks) occur in three isoenzyme forms, Itpka/b and c, in human, rat and mouse. They share a catalytic domain relatively well conserved at the C-terminal end and a quite isoenzyme specific regulatory domain at the N-terminal end of the protein
Rattus norvegicus
evolution
inositol(1,4,5)trisphosphate 3-kinases (Itpks) occur in three isoenzyme forms, Itpka/b and c, in human, rat and mouse. They share a catalytic domain relatively well conserved at the C-terminal end and a quite isoenzyme specific regulatory domain at the N-terminal end of the protein
Homo sapiens
evolution
inositol(1,4,5)trisphosphate 3-kinases (Itpks) occur in three isoenzyme forms, Itpka/b and c, in human, rat and mouse. They share a catalytic domain relatively well conserved at the C-terminal end and a quite isoenzyme specific regulatory domain at the N-terminal end of the protein
Mus musculus
malfunction
isozyme Itpka-deficient mice exhibit increased LTP in the CA1 region of the hippocampus
Mus musculus
malfunction
mice deficient for Itpkb have a severe defect in thymocytes differentiation and thus lack peripheral T cells
Mus musculus
metabolism
1D-myo-inositol 1,3,4,5-tetrakisphosphate, Ins(1,3,4,5)P4 can interact with a relatively specific Ins(1,3,4,5)P4 binding protein Rasa3, alternatively, Ins(1,3,4,5)P4 can also compete with phosphoinositides to the binding of PH domain containing proteins such as Akt, protein kinase B. In neutrophils and hematopoietic progenitors, elevated levels of Ins(1,3,4,5)P4 inhibit the recruitment of Akt at the plasma membrane, and its activation, acting as a competitor of PtdIns(3,4,5)P3 binding to its PH domain
Rattus norvegicus
metabolism
1D-myo-inositol 1,3,4,5-tetrakisphosphate, Ins(1,3,4,5)P4 can interact with a relatively specific Ins(1,3,4,5)P4 binding protein Rasa3, alternatively, Ins(1,3,4,5)P4 can also compete with phosphoinositides to the binding of PH domain containing proteins such as Akt, protein kinase B. In neutrophils and hematopoietic progenitors, elevated levels of Ins(1,3,4,5)P4 inhibit the recruitment of Akt at the plasma membrane, and its activation, acting as a competitor of PtdIns(3,4,5)P3 binding to its PH domain
Homo sapiens
metabolism
1D-myo-inositol 1,3,4,5-tetrakisphosphate, Ins(1,3,4,5)P4 can interact with a relatively specific Ins(1,3,4,5)P4 binding protein Rasa3, alternatively, Ins(1,3,4,5)P4 can also compete with phosphoinositides to the binding of PH domain containing proteins such as Akt, protein kinase B. In neutrophils and hematopoietic progenitors, elevated levels of Ins(1,3,4,5)P4 inhibit the recruitment of Akt at the plasma membrane, and its activation, acting as a competitor of PtdIns(3,4,5)P3 binding to its PH domain
Mus musculus
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
Rattus norvegicus
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
Homo sapiens
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
Mus musculus
additional information
ITPKC functional polymorphism associates with Kawasaki disease susceptibility
Homo sapiens
physiological function
in natural killer (NK) cells, isozyme Itpkb promotes NK-cell terminal maturation but limits NK-cell effector functions
Homo sapiens
physiological function
in natural killer (NK) cells, isozyme Itpkb promotes NK-cell terminal maturation but limits NK-cell effector functions. Itpka and Itpkb isoforms inhibit neurite outgrowth in PC12 cells, while isozyme Itpkc does not
Rattus norvegicus
physiological function
in natural killer (NK) cells, isozyme Itpkb promotes NK-cell terminal maturation but limits NK-cell effector functions. Itpkb controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice
Mus musculus
physiological function
isozyme Itpka contains an F-actin binding site at the N-terminal part that confers to Itpka the properties of an F-actin bundling protein with two major consequences: it can reorganize the cytoskeletal network, particularly in dendritic spines, and it can provide an opportunity for Ins(1,3,4,5)P4 to act very locally as second messenger. Isozyme Itpka is an F-actin bundling protein regulating dendritic spines structural plasticity and a scaffold protein for synaptic rac signaling, Itpka overexpression induces cytoskeletal reorganization, high expression of Itpka in cancer cells increases invasion and migration in vitro
Homo sapiens
physiological function
isozyme Itpka contains an F-actin binding site at the N-terminal part that confers to Itpka the properties of an F-actin bundling protein with two major consequences: it can reorganize the cytoskeletal network, particularly in dendritic spines, and it can provide an opportunity for Ins(1,3,4,5)P4 to act very locally as second messenger. Isozyme Itpka is an F-actin bundling protein regulating dendritic spines structural plasticity and a scaffold protein for synaptic rac signaling, Itpka overexpression induces cytoskeletal reorganization, high expression of Itpka in cancer cells increases invasion and migration in vitro
Mus musculus
physiological function
isozyme Itpka contains an F-actin binding site at the N-terminal part that confers to Itpka the properties of an F-actin bundling protein with two major consequences: it can reorganize the cytoskeletal network, particularly in dendritic spines, and it can provide an opportunity for Ins(1,3,4,5)P4 to act very locally as second messenger. Isozyme Itpka is an F-actin bundling protein regulating dendritic spines structural plasticity and a scaffold protein for synaptic rac signaling, Itpka overexpression induces cytoskeletal reorganization, high expression of Itpka in cancer cells increases invasion and migration in vitro. Itpka and Itpkb isoforms inhibit neurite outgrowth in PC12 cells, while isozyme Itpkc does not
Rattus norvegicus
physiological function
Itpka and Itpkb isoforms inhibit neurite outgrowth in PC12 cells, while isozyme Itpkc does not
Rattus norvegicus
Other publictions for EC 2.7.1.127
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737402
Erneux
Inositol(1,4,5)P3 3-kinase iso ...
Mus musculus, Rattus norvegicus, Homo sapiens
Adv. Biol. Regul.
60
135-143
2016
16
-
9
-
-
-
-
-
7
18
3
9
-
15
-
5
1
-
-
67
-
-
9
9
27
-
-
-
-
-
-
-
9
-
-
-
16
-
9
9
-
-
-
-
-
-
-
7
18
3
9
-
-
5
1
-
67
-
-
9
9
-
-
-
-
-
-
-
-
-
31
31
-
-
-
737403
Scoumanne
Specific expression and functi ...
Mus musculus
Adv. Biol. Regul.
62
1-10
2016
-
-
1
-
-
-
-
-
3
-
1
1
-
5
-
-
-
-
-
20
-
-
1
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
3
-
1
1
-
-
-
-
-
20
-
-
1
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
738022
Koester
Inositol-1,4,5-trisphosphate-3 ...
Mus musculus, Mus musculus C57BL/6
Cell. Signal.
28
83-90
2016
-
-
1
-
-
-
-
-
1
2
-
2
-
4
-
-
1
-
-
3
-
-
2
-
2
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
2
-
2
-
-
-
1
-
3
-
-
2
-
-
-
-
-
1
-
-
-
-
2
2
-
-
-
739679
Chung
The role of inositol 1,4,5-tri ...
Mus musculus, Mus musculus C57BL/6N
Sci. Rep.
6
23757
2016
-
-
1
-
-
-
-
-
1
2
-
2
-
8
-
-
-
-
-
3
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
2
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
738088
Ashour
The catalytic domain of inosit ...
Homo sapiens
Cytoskeleton (Hoboken)
72
93-100
2015
-
-
-
-
1
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
1
3
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
738216
Koenig
Regulation of NGF-driven neuri ...
Rattus norvegicus
FEBS J.
282
2553-2569
2015
-
-
-
-
3
-
-
-
3
3
-
3
-
5
-
-
-
-
-
6
-
-
3
-
6
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
3
-
-
-
-
-
3
3
-
3
-
-
-
-
-
6
-
-
3
-
-
-
-
-
-
-
-
-
-
8
8
-
-
-
737647
Franco-Echevarria
A new calmodulin-binding motif ...
Homo sapiens
Biochem. J.
463
319-328
2014
1
-
-
1
-
-
-
-
-
2
-
1
-
4
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
737961
Stygelbout
Inositol trisphosphate 3-kinas ...
Mus musculus, Homo sapiens
Brain
137
537-552
2014
-
-
-
-
-
-
-
-
-
4
-
2
-
12
-
-
-
-
-
6
-
-
2
-
4
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
2
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737400
Pouillon
-
Inositol 1,4,5-trisphosphate 3 ...
Mus musculus
Adv. Biol. Regul.
53
39-50
2013
-
-
-
-
1
-
-
-
-
2
-
1
-
1
-
-
-
-
-
9
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
2
-
1
-
-
-
-
-
9
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
737593
Schroeder
Identification of a new membra ...
Homo sapiens
Biochem. Biophys. Res. Commun.
439
228-234
2013
-
-
1
-
-
-
4
1
-
1
-
1
-
1
-
-
1
-
-
3
-
-
1
-
2
1
-
-
-
1
-
-
1
-
-
3
-
-
1
1
-
-
-
3
4
-
1
-
1
-
1
-
-
-
1
-
3
-
-
1
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
722003
Windhorst
Inositol-1,4,5-trisphosphate 3 ...
Homo sapiens
Cell. Signal.
24
750-757
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
722753
Lee
Inositol 1,4,5-trisphosphate 3 ...
Rattus norvegicus
J. Biol. Chem.
287
15981-15995
2012
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722735
Nalaskowski
Human inositol 1,4,5-trisphosp ...
Homo sapiens
J. Biol. Chem.
286
4500-4510
2011
-
-
-
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722002
Terhzaz
Cell-specific inositol 1,4,5 t ...
Drosophila melanogaster
Cell. Signal.
22
737-748
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
722381
Marechal
Inositol 1,4,5-trisphosphate 3 ...
Mus musculus
Immunobiology
216
103-109
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
699006
Windhorst
Inositol-1,4,5-trisphosphate-3 ...
Homo sapiens
J. Biol. Chem.
285
5541-5554
2009
1
-
3
-
1
-
1
-
-
-
-
1
-
7
-
-
1
-
-
13
2
-
1
-
3
-
-
-
-
1
-
-
-
-
-
1
1
-
3
-
-
1
-
1
1
-
-
-
-
-
1
-
-
-
1
-
13
2
-
1
-
-
-
-
-
1
-
-
-
4
2
2
4
-
-
699348
Miller
Inositol 1,4,5-trisphosphate 3 ...
Mus musculus
J. Immunol.
182
4696-4704
2009
-
-
1
-
-
-
-
-
-
1
-
1
-
7
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
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-
1
-
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-
-
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-
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1
-
1
-
-
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-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
699694
Kim
Inositol 1,4,5-trisphosphate 3 ...
Mus musculus, Rattus norvegicus
J. Neurosci.
29
14039-14049
2009
2
-
2
-
1
-
-
-
-
2
-
2
-
4
-
-
-
-
-
5
-
-
2
-
4
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
1
-
-
-
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