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Information on EC 2.7.1.127 - inositol-trisphosphate 3-kinase
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2.7.1.127 inositol-trisphosphate 3-kinaseIUBMB Comments
Activated by Ca2+. Three isoforms have been shown to exist .
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Word Map
- 2.7.1.127
- 1,3,4,5-tetrakisphosphate
- kawasaki
-
vasculitis
-
5-phosphatase
- tetrakisphosphate
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
1D-myo-inositol-trisphosphate 3-kinase, Arg82, ArgRIII, D-myo-inositol 1,4,5-trisphosphate 3-kinase, GsIP3K-A, HsIP3K-A, inositol (1,4,5) trisphosphate 3 kinase B, inositol (1,4,5) trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase A, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1D-myo-inositol-trisphosphate 3-kinase
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D-myo-inositol 1,4,5-trisphosphate 3-kinase
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inositol (1,4,5) trisphosphate 3 kinase B
inositol 1,4,5-trisphosphate 3-kinase
inositol 1,4,5-trisphosphate 3-kinase A
inositol 1,4,5-trisphosphate 3-kinase B
inositol 1,4,5-trisphosphate 3-kinase C
inositol 1,4,5-trisphosphate kinase
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inositol polyphosphate multikinase
inositol trisphosphate 3-kinase B
inositol(1,4,5)P3 3-kinase
inositol(1,4,5)trisphosphate 3-kinases
inositol-1,4,5-trisphosphate 3-kinase
inositol-1,4,5-trisphosphate-3-kinase
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inositol-1,4,5-trisphosphate-3-kinase-A
Ins(1,4,5)P3 3-kinase
Ins(1,4,5)P3 3-kinase isoform B
InsP3 3-kinase
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IP3 3-kinase
IP3K
IP3K-A
IP3K-B
IP3K-C
IP3kin
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IPMK
ITPKA
Itpkb
Itpkc
kinase (phosphorylating), inositol 1,4,5-trisphosphate 3-
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additional information
inositol 1,4,5-trisphosphate 3-kinase
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Ins(1,4,5)P3 3-kinase
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IP3K
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IP3K
The IP3K family consists of three isoenzymes referred to as IP3K-A, IP3K-B, and IP3K-C differing in their degree of activation by Ca2+-calmodulin, affinity for inositol-1,4,5-trisphosphate, tissue and intracellular distribution
additional information
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the enzyme belongs tot he IPK family, structure comparisons
additional information
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the enzyme is a member of the protein kinase superfamily
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
catalytic mechanism involving the 3-hydroxygroup of the substrate, substrate recognition
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ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
catalytic mechanism, ATP, substrate and product binding
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ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
catalytic core structure, substrate binding and catalytic mechanism, structure-function realtionship
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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phospho-group transfer
Phosphorylation
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase
Activated by Ca2+. Three isoforms have been shown to exist [3].
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CAS REGISTRY NUMBER
COMMENTARY
106283-10-7
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 1D-myo-inositol 1,4,5-triphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
ATP + 1D-myo-inositol 2,4,5-trisphosphate
ADP + 1D-myo-inositol 2,4,5,6-tetrakisphosphate
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recombinant, catalytically active fragment of isoform C, in the presence of Ins(1,3,4,5)P4, authentic side activity of isoform C
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?
ATP + D-2-deoxy-myo-inositol 1,4,5-trisphosphate
ADP + D-2-deoxy-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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specific for phosphorylation of the 3-position
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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target enzyme of cellular regulation, enzyme controls the rate of InsP3 metabolism
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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role in limiting the availability of InsP3 for Ca2+ release in smooth muscle relaxation
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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inositol phosphate metabolism
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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important alternative route for inositol 1,4,5-trisphosphate metabolism in skeletal muscle
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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regulatory mechanism of isoenzyme B involving phosphorylation by both protein kinase C and CaM kinase II
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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regulation mechanism of isoenzyme A involving CaM kinase II-mediated phosphorylation
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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inositol 1,4,5-trisphosphate is a second messenger
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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inositol 1,4,5-trisphosphate is a second messenger
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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role of the 3 isoforms as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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regulation mechanism of isoenzyme A in brain involving CaM kinase II-mediated phosphorylation, role of Ins(1,4,5)P3 3-kinase in brain
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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key enzyme in inositol phosphate signaling pathway
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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substrate and product binding site structure
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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role in rapidly metabolizing the pool of Ins(1,4,5)P3 that is generated when phospholipase C-coupled receptors are activated, the product Ins(1,3,4,5)P4 can protect Ins(1,4,5)P3 against hydrolysis and therefore increase its effectiveness, detailed consequences of Ins(1,3,4,5)P4 generation in the cell, all 3 isoenzymes are regulated by calmodulin, 2 isoenzymes are regulated by a Ca2+/calmodulin-dependent protein kinase II
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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enzyme phosphorylates the 3'-position of the inositol ring to convert the substrate to the product
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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multiple regulation mechanisms of enzyme isoform A and B
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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domain structure of IP3K-C
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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regulatory mechanism of isoenzyme B involving phosphorylation by both protein kinase C and CaM kinase II
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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regulation mechanism of isoenzyme A involving CaM kinase II-mediated phosphorylation
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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environment of the active site, proposed binding site model for Ins(1,4,5)P3
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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also phosphorylates the 1,2-cyclic form of myo-inositol 1,4,5-trisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
specific for phosphorylation of the 3-position
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
specific for phosphorylation of the 3-position
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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enzyme is specific for phosphorylating the position 3 of the myo-inositol ring and requires vicinal phosphates in the 4 and 5 positions
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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isoform A: N-terminal 66-amino acid F-actin-binding region
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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differential expression and regulation of the two enzyme isoforms A and B provides multiple mechanisms for regulating the cytosolic level of inositol 1,4,5-trisphosphate in cells, regulation mechanisms
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate have separate second messenger roles, perhaps both relating to Ca2+-signaling events
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
phosphorylation of IP3 in dentritic spines to produce IP4 is important for modulating the compartmentalization of calcium at synapses, control of calcium signals, the rapid, localized synthesis of IP4 may have complex effects on cytosolic calcium and on the molecular mechanisms that control learning and memory
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
IP3K regulates the intracellular level of the 2 second messengers Ins(1,4,5)P3 and Ins(1,3,4,5)P4
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-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulation mechanism of isoenzyme A in brain involving CaM kinase II-mediated phosphorylation, role of Ins(1,4,5)P3 3-kinase in brain
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
IP3K isoform C: nucleocytoplasmic shuttling, particular role in nuclear inositol trisphosphate phosphorylation and cellular growth, enzyme seems to function during the intervalls between signaling events, keeps the resting Ins(1,4,5)P3 very low and provides a basal Ins(1,3,4,5)P4 production in the absence of stimulatory signals from the exterior
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
enzyme occupies a central position in inositol phosphate metabolism by terminating the Ca2+ mobilizing of InsP3 and by generating InsP4
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol tris/tetrakisphosphate pathway
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
isoform B may play a significant role in the regulation of Ins(1,4,5)P3 levels, and consequently in Ca2+ responses following stimulation of cells with Ins(1,4,5)P3-elevating agonists
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate mobilizes Ca2+ from the intracellular stores of permeabilized cells, enzyme is Ca2+-regulated
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
important regulatory role in inositol phosphate signaling by promoting the formation of additional inositol polyphosphate isomers
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate 3-kinase reaction of the inositol polyphosphate multikinase, EC 2.7.1.151
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
InsP3K activity is a determinant of the extent of basal Ras activation in mast cells and of the Ras activation that follows antigenic crosslinking of the FcepsilonRI
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate 3-kinase reaction of the inositol polyphosphate multikinase, EC 2.7.1.151
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate 3-kinase reaction of the inositol polyphosphate multikinase, EC 2.7.1.151
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involvement of a calmodulin-dependent protein kinase II-mediated phosphorylation in enzyme regulation, enzyme decreases the Ins(1,4,5)P3 concentration, this second messenger binds to the InsP3 receptor to release Ca2+ from intracellular stores, the activation of enzyme may be involved in the Ca2+-dependent down regulation of the InsP3-mediated Ca2+ release, enzyme may play a key role in regulating signals arising from the phospholipase C-related transduction system
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
additional information
?
-
-
the enzyme might be involved in oxidative damage resistance
-
-
-
additional information
?
-
-
the 3 isoenzymes A, B and C can be distinguished by their N-terminal sequence, sensitivity to Ca2+/calmodulin and localization on transfection in COS-7 cells
-
-
-
additional information
?
-
-
the enzyme might be involved in brain development, memory, and learning
-
-
-
additional information
?
-
-
the enzyme binds to F-actin in the cellular actin cytoskeleton with its F-actin domain at the N-terminus, the C-terminal fragment cannot bind to F-actin
-
-
-
additional information
?
-
-
isozyme B controls positive selection of T cells and modulates Erk activity, the enzyme is important in Ras signaling which is important for Erk activation, overview
-
-
-
additional information
?
-
-
isozyme B controls positive selection of T cells and modulates Erk activity, the enzyme is important in Ras signaling which is important for Erk activation, overview
-
-
-
additional information
?
-
-
the enzyme might be involved in brain development, memory, and learning
-
-
-
additional information
?
-
the enzyme binds to F-actin in the cellular actin cytoskeleton with its F-actin domain at the N-terminus, the C-terminal fragment cannot bind to F-actin
-
-
-
additional information
?
-
-
the enzyme contains a catalytic domain and a 4-helix substrate binding domain, both are in an open conformation with respect to each other, thus substrate recognition and catalysis involve a dynamic conformational cycle
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 1D-myo-inositol 1,4,5-triphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
Q80ZG2
-
-
-
r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
target enzyme of cellular regulation, enzyme controls the rate of InsP3 metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
role in limiting the availability of InsP3 for Ca2+ release in smooth muscle relaxation
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
important alternative route for inositol 1,4,5-trisphosphate metabolism in skeletal muscle
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
P23677
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
P27987, Q96DU7
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
P23677
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
P23677, P27987
-
-
-
r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulatory mechanism of isoenzyme B involving phosphorylation by both protein kinase C and CaM kinase II
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
role of the 3 isoforms as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulation mechanism of isoenzyme A in brain involving CaM kinase II-mediated phosphorylation, role of Ins(1,4,5)P3 3-kinase in brain
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
key enzyme in inositol phosphate signaling pathway
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
role in rapidly metabolizing the pool of Ins(1,4,5)P3 that is generated when phospholipase C-coupled receptors are activated, the product Ins(1,3,4,5)P4 can protect Ins(1,4,5)P3 against hydrolysis and therefore increase its effectiveness, detailed consequences of Ins(1,3,4,5)P4 generation in the cell, all 3 isoenzymes are regulated by calmodulin, 2 isoenzymes are regulated by a Ca2+/calmodulin-dependent protein kinase II
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
B2RXC2
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
Q7TS72, Q8R071
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
enzyme phosphorylates the 3'-position of the inositol ring to convert the substrate to the product
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
Q8R071
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
Q8R071
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
P17105, P42335, Q80ZG2
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulatory mechanism of isoenzyme B involving phosphorylation by both protein kinase C and CaM kinase II
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
differential expression and regulation of the two enzyme isoforms A and B provides multiple mechanisms for regulating the cytosolic level of inositol 1,4,5-trisphosphate in cells, regulation mechanisms
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate have separate second messenger roles, perhaps both relating to Ca2+-signaling events
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
phosphorylation of IP3 in dentritic spines to produce IP4 is important for modulating the compartmentalization of calcium at synapses, control of calcium signals, the rapid, localized synthesis of IP4 may have complex effects on cytosolic calcium and on the molecular mechanisms that control learning and memory
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
IP3K regulates the intracellular level of the 2 second messengers Ins(1,4,5)P3 and Ins(1,3,4,5)P4
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulation mechanism of isoenzyme A in brain involving CaM kinase II-mediated phosphorylation, role of Ins(1,4,5)P3 3-kinase in brain
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
IP3K isoform C: nucleocytoplasmic shuttling, particular role in nuclear inositol trisphosphate phosphorylation and cellular growth, enzyme seems to function during the intervalls between signaling events, keeps the resting Ins(1,4,5)P3 very low and provides a basal Ins(1,3,4,5)P4 production in the absence of stimulatory signals from the exterior
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
enzyme occupies a central position in inositol phosphate metabolism by terminating the Ca2+ mobilizing of InsP3 and by generating InsP4
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol tris/tetrakisphosphate pathway
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
isoform B may play a significant role in the regulation of Ins(1,4,5)P3 levels, and consequently in Ca2+ responses following stimulation of cells with Ins(1,4,5)P3-elevating agonists
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate mobilizes Ca2+ from the intracellular stores of permeabilized cells, enzyme is Ca2+-regulated
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
important regulatory role in inositol phosphate signaling by promoting the formation of additional inositol polyphosphate isomers
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
InsP3K activity is a determinant of the extent of basal Ras activation in mast cells and of the Ras activation that follows antigenic crosslinking of the FcepsilonRI
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
P17105
reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involvement of a calmodulin-dependent protein kinase II-mediated phosphorylation in enzyme regulation, enzyme decreases the Ins(1,4,5)P3 concentration, this second messenger binds to the InsP3 receptor to release Ca2+ from intracellular stores, the activation of enzyme may be involved in the Ca2+-dependent down regulation of the InsP3-mediated Ca2+ release, enzyme may play a key role in regulating signals arising from the phospholipase C-related transduction system
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
-
?
additional information
?
-
-
the enzyme might be involved in oxidative damage resistance
-
-
-
additional information
?
-
-
the enzyme might be involved in brain development, memory, and learning
-
-
-
additional information
?
-
-
isozyme B controls positive selection of T cells and modulates Erk activity, the enzyme is important in Ras signaling which is important for Erk activation, overview
-
-
-
additional information
?
-
-
isozyme B controls positive selection of T cells and modulates Erk activity, the enzyme is important in Ras signaling which is important for Erk activation, overview
-
-
-
additional information
?
-
-
the enzyme might be involved in brain development, memory, and learning
-
-
-
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ATP
-
binding site structure, role of ATP-binding in the catalytic mechanism and substrate inhibition of the catalytic domain
ATP
-
-
640733, 640734, 640751, 640752, 640755, 640756, 640758, 660978, 661446, 662346, 737402, 737593, 737647, 737961, 738088
ATP
-
-
640731, 640736, 640739, 640746, 640749, 640751, 640753, 640756, 640757, 640758, 640759, 640760, 640761, 660978, 661334, 661446, 661488, 662346, 663233, 737402, 738216
Calmodulin
-
17fold stimulation by Ca2+/calmodulin at saturating calmodulin and 0.01 mM free Ca2+; activation by Ca2+/calmodulin
Calmodulin
-
activation by Ca2+/calmodulin; Ca2+/calmodulin-dependent, 10fold stimulation, reversed upon chelation of Ca2+ by EGTA; mechanism of activation
Calmodulin
-
3-6fold stimulation by Ca2+/calmodulin; activation by Ca2+/calmodulin
Calmodulin
-
activation by Ca2+/calmodulin; maximally 5fold stimulation by 0.01 mM Ca2+/calmodulin, reversible
Calmodulin
-
activation by Ca2+/calmodulin; up to 30fold stimulation by Ca2+/calmodulin
Calmodulin
-
6-7fold stimulation by Ca2+/calmodulin; activation by Ca2+/calmodulin; mechanism of activation
Calmodulin
-
activation by Ca2+/calmodulin; effects of Ca2+/calmodulin on enzyme activity
Calmodulin
-
1.5fold activation by Ca2+/calmodulin; activation by Ca2+/calmodulin
Calmodulin
-
activation by Ca2+/calmodulin; maximal at 50 nM calmodulin, reversed by EGTA, interaction between the Ca2+-calmodulin complex and enzyme
Calmodulin
-
activation by Ca2+/calmodulin; the 3 isoenzymes A, B and C can be distinguished by their sensitivity to Ca2+/calmodulin
Calmodulin
-
activation by Ca2+/calmodulin; phosphorylation of Thr-311 of isoenzyme A by CaM kinase II results in a 25fold increase in sensitivity to the Ca2+/calmodulin complex, maximally 2-2.5fold stimulation by the Ca2+/calmodulin complex
Calmodulin
-
activation by Ca2+/calmodulin
Calmodulin
-
activation by Ca2+/calmodulin; phosphorylation of isoenzyme B has no effect on the sensitivity to the Ca2+/calmodulin complex
Calmodulin
-
activation by Ca2+/calmodulin; isoforms A and B are differentially regulated by Ca2+/calmodulin, isoform A: 2.5fold stimulation, isoform B: 20fold stimulation
Calmodulin
-
activation by Ca2+/calmodulin; isoform C is strongly activated by Ca2+/calmodulin in a substrate concentration-dependent manner
Calmodulin
-
The binding domain is present in all IP3K isoforms, involved in inhibitor binding.
Calmodulin
The binding domain is present in all IP3K isoforms; The binding domain is present in all IP3K isoforms
Calmodulin
The binding domain is present in all IP3K isoforms, involved in inhibitor binding.
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Mg2+
additional information
-
assay in presence of Triton X-100 and ethylene glycol bis-(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid
Ca2+
-
activation by Ca2+/calmodulin; not activated by free Ca2+; only together with calmodulin, completely reversible
Ca2+
-
6-7fold stimulation by Ca2+/calmodulin; activation by Ca2+/calmodulin; mechanism of activation; not activated by free Ca2+
Ca2+
-
activation by Ca2+/calmodulin; maximal at 0.01-0.1 mM Ca2+, interaction between the Ca2+-calmodulin complex and enzyme
Ca2+
-
activation by Ca2+/calmodulin; at physiological concentrations
Ca2+
-
activation by Ca2+/calmodulin; not activated by free Ca2+; only together with calmodulin, completely reversible
Ca2+
-
17fold stimulation by Ca2+/calmodulin at saturating calmodulin and 0.01 mM free Ca2+; activation by Ca2+/calmodulin
Ca2+
-
activation by Ca2+/calmodulin; at physiological concentrations; mechanism of activation
Ca2+
-
activation by Ca2+/calmodulin; isoenzyme C is regulated by Ca2+ to a lesser extend than isoenzymes A and B
Ca2+
-
activation by Ca2+/calmodulin; the 3 isoenzymes A, B and C can be distinguished by their sensitivity to Ca2+/calmodulin
Ca2+
-
activation by Ca2+/calmodulin; phosphorylation of Thr-311 of isoenzyme A by CaM kinase II results in a 25fold increase in sensitivity to the Ca2+/calmodulin complex
Ca2+
the enzyme is activated by Ca2+/calmodulin; the enzyme is activated by Ca2+/calmodulin; the enzyme is highly activated by Ca2+/calmodulin
Ca2+
-
IP3K-A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate
Ca2+
-
the enzyme is activated by Ca2+/calmodulin; the enzyme is activated by Ca2+/calmodulin; the enzyme is highly activated by Ca2+/calmodulin
Ca2+
-
activation by Ca2+/calmodulin; at physiological concentrations; not activated by free Ca2+
Ca2+
-
3-6fold stimulation by Ca2+/calmodulin; activation by Ca2+/calmodulin; not activated by free Ca2+
Ca2+
-
activation by Ca2+/calmodulin; not activated by free Ca2+; only together with calmodulin, completely reversible
Ca2+
-
1.5fold activation by Ca2+/calmodulin; activation by Ca2+/calmodulin; not activated by free Ca2+
Ca2+
-
activation by Ca2+/calmodulin; phosphorylation of isoenzyme B has no effect on the sensitivity to the Ca2+/calmodulin complex
Ca2+
-
activation by Ca2+/calmodulin; isoforms A and B are differentially regulated by Ca2+/calmodulin, isoform A: 2.5fold stimulation, isoform B: 20fold stimulation
Ca2+
-
activation by Ca2+/calmodulin; isoform C is strongly activated by Ca2+/calmodulin in a substrate concentration-dependent manner
Ca2+
-
isozyme IP33K-A: 3-6fold activation by calmodulin in a Ca2+-dependent manner
Ca2+
-
IP3KA is significantly activated by Ca2+/calmodulin; IP3KB is significantly activated by Ca2+/calmodulin; IP3KC is weakly activated by Ca2+/calmodulin
Ca2+
IP3K-A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate
Ca2+
-
the enzyme is activated by Ca2+/calmodulin; the enzyme is activated by Ca2+/calmodulin; the enzyme is highly activated by Ca2+/calmodulin
Ca2+
-
activation by Ca2+/calmodulin; at physiological concentrations; effects of Ca2+/calmodulin on enzyme activity, the calmodulin antagonists W-7 or chlorpromazine inhibit the Ca2+-enhancement of enzyme activity
Ca2+
-
activation by Ca2+/calmodulin; activation is mediated by calmodulin and the calmodulin-dependent protein kinase II
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(2'S)-1D-1,2-O-[(2'-phosphoryloxy)propane-1',3'-diyl]-myo-inositol 4,5-bisphosphate
-
synthetic bicyclic inositol trisphosphate S epimer, IC50 is 0.156 mM
7-methylsulfanyl-3-phenyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one
-
55% inhibition at 0.04 mM
D-2-deoxyinositol 1,3,4,5-tetrakisphosphate
-
strong inhibition of isozyme A, IC50 is 0.0054 mM
D-2-deoxyinositol 1,4,5-trisphosphate
-
strong inhibition of isozyme A, IC50 is 0.0017 mM
D-3-deoxyinositol 1,4,6-trisphosphate
-
strong inhibition of isozyme A, IC50 is 0.0014 mM
D-6-deoxyinositol 1,3,4,5-tetrakisphosphate
-
strong inhibition of isozyme A, IC50 is 0.0051 mM
D-myo-inositol 1,4,5-trisphosphate
-
strong inhibition, purified recombinant enzyme, IC50 value is 0.003 mM in absence of Ca2+
D-scyllo-inositol 1,2,3,4-tetrakisphosphate
-
purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+
D-scyllo-inositol 1,2,4-trisphosphate
-
purified recombinant enzyme, IC50 value is 0.044 mM in absence of Ca2+
inositol phosphate
-
inhibitory effects of all possible 38 regioisomers of synthetic inositol phosphates, only inositol trisphosphates and tetrakisphosphates inhibit, not or very weak: inositol monophosphates, bisphosphates and pentakisphosphates, the recognition of myo-inositol phosphate regioisomers is highly structure-selective
L-scyllo-inositol 1,2,3,4-tetrakisphosphate
-
purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+
L-scyllo-inositol 1,2,4-trisphosphate
-
purified recombinant enzyme, IC50 value is 0.006 mM in absence of Ca2+
N-(1,2-benzoxazol-3-yl)-4-methylbenzamide
-
68% inhibition at 0.04 mM, mixed type inhibitor, that is nearly completely taken up by H1299 cells and remains stable after cellular uptake, the compound exhibits a robust stability and a high membrane permeability. The inhibitor provides the possibility to partly inhibit the metastasis-promoting effect of ITPKA in lung tumor cells. Inhibition mechanism of BAMB-4, overview
N-(4-ethoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboxamide
-
87% inhibition at 0.04 mM
protein kinase A
-
isoforms A and B are differentially regulated via phosphorylation by the cAMP-dependent protein kinase, isoform A: stimulation in the presence or absence of Ca2+/calmodulin, isoform B: no effect on activity in the absence of Ca2+/calmodulin, 45% inhibition in the presence of Ca2+/calmodulin
-
RS-20
-
calmodulin antagonist, prevents the Ca2+/calmodulin-mediated activation
-
scyllo-inositol 1,2,3,5-tetrakisphosphate
-
weak inhibition, purified recombinant enzyme, IC50 value is 0.028 mM in absence of Ca2+
scyllo-inositol 1,2,3-trisphosphate
-
purified recombinant enzyme, IC50 value is 0.027 mM in absence of Ca2+
scyllo-inositol 1,2,4,5-tetrakisphosphate
-
weak inhibition, purified recombinant enzyme, IC50 value is 0.039 mM in absence of Ca2+
scyllo-inositol 1,3,5-trisphosphate
-
purified recombinant enzyme, IC50 value is 0.090 mM in absence of Ca2+
TSH
-
thyroid-stimulating hormone, inhibits at a physiological concentration, inhibition is mimicked by dibuturyl cyclic AMP and forskolin, mechanism
1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
marked product inhibition, isoforms A and B
1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
product inhibition, IC50 is 0.013 mM
1D-myo-inositol 1,4,5-trisphosphate
-
substrate inhibition of the catalytic domain
1D-myo-inositol 1,4,5-trisphosphate
-
recombinant, catalytically active fragment of isoform C, substrate inhibition by high concentrations
3',4',7,8-tetrahydroxyflavone
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
3',4',7,8-tetrahydroxyflavone
-
the point mutant K336Q reveals a drastically reduced inhibition by THF. Substitution of Lys336 leads to a 260fold increase in the IC50. On the other hand, kinetic parameters of the enzyme with respect to both substrates are nearly unchanged. This region shows high homology between IP3K isoforms.
3',4',7,8-tetrahydroxyflavone
-
inhibition of isozyme A, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
3',4',7,8-tetrahydroxyflavone
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
aurintricarboxylic acid
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
aurintricarboxylic acid
-
inhibition of isozyme A and isozyme B, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
aurintricarboxylic acid
-
strong inhibition, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
chlorpromazine
-
calmodulin-antagonist, inhibits Ca2+-activated enzyme activity
ellagic acid
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
ellagic acid
-
inhibition of isozyme B, slight inhibition of isozyme A, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
epicatechin-3-gallate
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
epicatechin-3-gallate
-
slight inhibition of isozyme A and isozyme B, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
epicatechin-3-gallate
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-triphosphate
epigallocatechin-3-gallate
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
epigallocatechin-3-gallate
-
inhibition of isozyme A, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
epigallocatechin-3-gallate
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-triphosphate
gossypol
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
gossypol
-
inhibition of isozyme A and isozyme B, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
gossypol
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
hypericin
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
hypericin
-
inhibition of isozyme A and isozyme B, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
hypericin
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-triphosphate
KN-62
-
calmodulin-dependent protein kinase II inhibitor; prevents the carbachol- or UTP-mediated activation
KN-62
-
calmodulin-dependent protein kinase II inhibitor; prevents the carbachol- or UTP-mediated activation
KN-62
-
calmodulin-dependent protein kinase II inhibitor; prevents the Ca2+/calmodulin-mediated activation
KN-93
-
calmodulin-dependent protein kinase II inhibitor; prevents the carbachol- or UTP-mediated activation
KN-93
-
calmodulin-dependent protein kinase II inhibitor; prevents the carbachol- or UTP-mediated activation
KN-93
-
calmodulin-dependent protein kinase II inhibitor; prevents the Ca2+/calmodulin-mediated activation
myricetin
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
myricetin
-
inhibition of isozyme A, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
myricetin
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide
-
i.e. W-7, calmodulin-antagonist; inhibits Ca2+-activated enzyme activity
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide
-
i.e. W-7, calmodulin-antagonist
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide
-
i.e. W-7, calmodulin-antagonist; inhibits Ca2+-activated enzyme activity
Protein kinase C
-
negative regulatory function, phosphorylates the enzyme at a serine residue
-
Protein kinase C
-
protein kinase C alone, without CaM kinase II, inhibits in the presence of Ca2+ and calmodulin
-
Protein kinase C
-
isoforms A and B are differentially regulated via phosphorylation by protein kinase C, isoform A: phosphorylated to the extent of 2 mol/mol, 72% inhibition in the absence of Ca2+/calmodulin, isoform B: phosphorylated to the extent of 2.7 mol/mol, no effect on activity in the absence of Ca2+/calmodulin, both isoforms are inhibited by 70% in the presence of Ca2+/calmodulin
-
Protein kinase C
-
negative regulatory function, phosphorylates the enzyme at Ser175, simultaneous phosphorylation at Ser109 and Ser175 also inactivates the enzyme
-
Protein kinase C
-
negative regulatory function, phosphorylates the enzyme at a Ser residue
-
quercetin
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
quercetin
-
inhibition of isozyme A, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
quercetin
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
Rose bengal
-
slight inhibition of isozyme B, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
additional information
-
IC50 values, overiew, the inhibition by the synthetic or plant phenols can in some cases be partially or completely reversed by Triton X-100, no inhibition by chlorogenic acid and by Rose Bengal
-
additional information
-
All inhibitors display a mixed-type inhibition with respect to ATP and a noncompetitive inhibition with respect to 1D-myo-inositol 1,4,5-triphosphate. Mutagenesis studies reveal that both the calmodulin binding and the ATP binding domains in IP3K are involved in inhibitor binding. Most discovered potent IP3K inhibitors exert antiproliferative effects on cultured cells in vitro or in animal experiments and tumor treatment studies in vivo.; Reversal of enzyme inhibition by addition of Triton X-100 and Ca2+-calmodulin.
-
additional information
-
IC50 values, overiew, inhibitory potency of the synthetic and plant phenolics, no inhibition by chlorogenic acid
-
additional information
All inhibitors display a mixed-type inhibition with respect to ATP and a noncompetitive inhibition with respect to inositol-1,4,5-trisphosphate. Mutagenesis studies reveal that both the calmodulin binding and the ATP binding domains in IP3K are involved in inhibitor binding. Most discovered potent IP3K inhibitors exert antiproliferative effects on cultured cells in vitro or in animal experiments and tumor treatment studies in vivo.; All inhibitors display a mixed-type inhibition with respect to ATP and a noncompetitive inhibition with respect to Ins(1,4,5)P3. Mutagenesis studies reveal that both the calmodulin binding and the ATP binding domains in IP3K are involved in inhibitor binding. Most discovered potent IP3K inhibitors exert antiproliferative effects on cultured cells in vitro or in animal experiments and tumor treatment studies in vivo.
-
additional information
All inhibitors display a mixed-type inhibition with respect to ATP and a noncompetitive inhibition with respect to inositol-1,4,5-trisphosphate. Mutagenesis studies reveal that both the calmodulin binding and the ATP binding domains in IP3K are involved in inhibitor binding. Most discovered potent IP3K inhibitors exert antiproliferative effects on cultured cells in vitro or in animal experiments and tumor treatment studies in vivo.; All inhibitors display a mixed-type inhibition with respect to ATP and a noncompetitive inhibition with respect to Ins(1,4,5)P3. Mutagenesis studies reveal that both the calmodulin binding and the ATP binding domains in IP3K are involved in inhibitor binding. Most discovered potent IP3K inhibitors exert antiproliferative effects on cultured cells in vitro or in animal experiments and tumor treatment studies in vivo.
-
additional information
-
in order to inhibit the metastasis-promoting activity of ITPKA, both its actin bundling and its InsP3kinase activity has to be blocked, inhibitor library screening, overview
-
additional information
-
not inhibited by GTP or 5'-guanylylimidodiphosphate
-
additional information
-
enzyme contains several motifs susceptible to a variety of proteases
-
additional information
-
inhibitor binding structures and mechanism, scyllo-inositol pentakisphosphate, scyllo-inositol hexakisphosphate, scyllo-inositol monophosphate, and scyllo-inositol S-bisphosphates are poor inhibitors
-
additional information
-
poor inhibition by adenophostin analogues xylo-furanophostin and furanophostin, by L-myo-inositol 2,4,5-trisphosphate, synthetic bicyclic inositol trisphosphate R epimer, and by epi-1D-myo-inositol 1,3,6-trisphosphate
-
additional information
-
IC50 values, overiew, no inhibition by chlorogenic acid, poor inhibition by rose bengal, and ellagic acid
-
additional information
All inhibitors display a mixed-type inhibition with respect to ATP and a noncompetitive inhibition with respect to 1D-myo-inositol 1,4,5-triphosphate. Mutagenesis studies reveal that both the calmodulin binding and the ATP binding domains in IP3K are involved in inhibitor binding. Most discovered potent IP3K inhibitors exert antiproliferative effects on cultured cells in vitro or in animal experiments and tumor treatment studies in vivo.; The flavonoids myricetin, 3',4',7,8-tetrahydroxyflavone, and epigallocatechin-3-gallate have a markedly stronger effect on isoforms A and C than on isoform B
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane
-
5-HT2 agonist DOI, 3fold activation
1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
recombinant, catalytically active fragment of isoform C, allosteric product activation in the absence of Ca2+/calmodulin, which per se activates enzyme and abolishes the allosteric effect
Ca2+/calmodulin
for enzyme activation, Ca2+/calmodulin, 2.15 microg/ml calmodulin and 10-20 microM free CaCl2 is added to the assay mixture
-
serotonin
-
potentiates enzyme activity mediated through the activation of 5-HT2 receptors, enzyme up-regulation occurs through activation of PLC-coupled serotoninergic receptors and requires the phosphorylation of the enzyme by the ubiquitous multimeric protein kinase CaMKII
Triton X-100
-
Antagonizing the effect of all inhibitors identified with GgIP3K-A. When 0.2% Triton X-100 is added to assays containing the respective inhibitors at IC50, the previous inhibition of GgIP3K-A is immediately reversed by an extent between 49 and 100%
Ca2+/CaM-dependent kinase II
-
i.e. CaMKII, activates the enzyme by phosphorylation of Thr311
-
Ca2+/CaM-dependent kinase II
-
i.e. CaMKII, activates the enzyme by phosphorylation of threonine residue
-
Ca2+/CaM-dependent kinase II
-
i.e. CaMKII, activates the enzyme by phosphorylation at a Thr residue
-
Calmodulin
-
2-3fold activation of isozyme IP33K-A and 7-8fold of isozyme IP33K-B, in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids
Calmodulin
the enzyme is activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain; the enzyme is activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain; the enzyme is highly activated by Ca2+/calmodulin, ten to twentyfold increase in activity in human platelets. The isozyme contains a CaM binding domain
Calmodulin
-
the enzyme is activated by Ca2+/calmodulin. The human isozyme IP3-3K A contains a CaM binding domain at residues 158-183, binding structure and identification all of the key residues involved in the interaction, overview
Calmodulin
-
the enzyme is activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain; the enzyme is activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain; the enzyme is highly activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain
Calmodulin
-
isozyme IP33K-A: 3-6fold activation in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids, residues Ser156-Leu189 and Trp165 are required
Calmodulin
-
the enzyme is activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain; the enzyme is activated by Ca2+/calmodulin. The isozyme contains a CaM binding domain; the enzyme is highly activated by Ca2+/calmodulin, two or threefold in rat brain. The isozyme contains a CaM binding domain
Calmodulin
-
up to 20fold activation in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids
CaM kinase II
-
phosphorylation of Thr-311 results in 8-10fold enzyme activation in the presence of 0.01 mM free Ca2+ and 0.002 mM calmodulin and in a 25fold increase in sensitivity to the Ca2+/calmodulin complex
-
CaM kinase II
-
phosphorylation of isoenzyme B by calmodulin kinase II and protein kinase C added together results in a maximal 60-70fold activation, no effect on the sensitivity to the Ca2+/calmodulin complex, CaM kinase II alone activates 35-40fold in the presence of Ca2+ and calmodulin
-
CaM kinase II
-
phosphorylation of isoenzyme B by calmodulin kinase II and protein kinase C added together results in a maximal 60-70fold activation, no effect on the sensitivity to the Ca2+/calmodulin complex, CaM kinase II alone activates 35-40fold in the presence of Ca2+ and calmodulin
-
cAMP-dependent protein kinase
-
i.e. PKA, activates the enzyme by phosphorylation at a serine residue
-
cAMP-dependent protein kinase
-
i.e. PKA, activates the enzyme by phosphorylation at Ser109, simultaneous phosphorylation at SEr109 and Ser175 inactivates the enzyme
-
cAMP-dependent protein kinase
-
i.e. PKA, activates the enzyme by phosphorylation at a Ser residue
-
Carbachol
-
6-8fold okadaic acid-sensitive activation, maximal at 0.01 mM, isoform B, carbachol-activated isoenzyme B shows a redistribution of enzyme from soluble to particulate fraction
Carbachol
-
3-5fold activation, maximal at 0.01-0.05 mM, isoenzyme A, increases the phosphorylation of enzyme
Carbachol
-
6-8fold okadaic acid-sensitive activation, maximal at 0.01 mM, isoform B, carbachol-activated isoenzyme B shows a redistribution of enzyme from soluble to particulate fraction; calphostin C, KN-93 or KN-62 partially prevents activation
Carbachol
-
activates the enzyme up to 7fold in rat brain cortical slices; activates the enzyme up to 7fold in rat brain cortical slices; activates the enzyme up to 7fold in rat brain cortical slices
protein kinase A
-
isoforms A and B are differentially regulated via phosphorylation by the cAMP-dependent protein kinase, isoform A: phosphorylated to the extent of 0.9 mol/mol, 2.5fold stimulation in the absence of Ca2+/calmodulin, 1.5fold stimulation in the presence of Ca2+/calmodulin, isoform B: phosphorylated to the extent of 1 mol/mol, no effect on activity in the absence of Ca2+/calmodulin, 45% inhibition in the presence of Ca2+/calmodulin
-
Protein kinase C
-
phosphorylation of isoenzyme B by calmodulin kinase II and protein kinase C added together results in a maximal 60-70fold activation, but protein kinase C alone inhibits in the presence of Ca2+ and calmodulin, no effect on the sensitivity to the Ca2+/calmodulin complex
-
Protein kinase C
-
phosphorylation of isoenzyme B by calmodulin kinase II and protein kinase C added together results in a maximal 60-70fold activation, but protein kinase C alone inhibits in the presence of Ca2+ and calmodulin, no effect on the sensitivity to the Ca2+/calmodulin complex
-
UTP
-
6-8fold okadaic acid-sensitive activation, maximal at 0.01 mM, isoform B, calphostin C, KN-93 or KN-62 partially prevents activation, UTP-activated isoenzyme B shows a redistribution of enzyme from soluble to particulate fraction
additional information
the enzyme is stimulated by purinergic agonists in human astrocytoma cells; the enzyme is stimulated by purinergic agonists in human astrocytoma cells; the enzyme is stimulated by purinergic agonists in human astrocytoma cells
-
additional information
-
enhanced inositol 1,4,5-trisphosphate 3-kinase A in the synaptic field by long-term potentiation induction in rat hippocampal neurons
-
additional information
-
isoenzymes A and B are not activated by protein kinase A
-
additional information
enhanced IP3K-A IR in the synaptic field by long-term potentiation induction in rat hippocampal neurons
-
additional information
-
phosphorylation activates the activity of isozyme Itpka
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Adenocarcinoma of Lung
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Adenocarcinoma of Lung
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
Alzheimer Disease
Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology.
Aneurysm
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.
Aneurysm
ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.
Aneurysm
Single-Nucleotide Polymorphism rs7251246 in ITPKC Is Associated with Susceptibility and Coronary Artery Lesions in Kawasaki Disease.
Arthritis
Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.
Autoimmune Diseases
Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.
Breast Neoplasms
Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.
Breast Neoplasms
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
Carcinogenesis
Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma.
Carcinogenesis
ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.
Carcinoma
Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.
Carcinoma
Genetic polymorphisms in the ITPKC gene and cervical squamous cell carcinoma risk.
Carcinoma
ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.
Carcinoma
The Expression of miR-375 Is Associated with Carcinogenesis in Three Subtypes of Lung Cancer.
Carcinoma
The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells.
Carcinoma, Hepatocellular
ITPKA expression is a novel prognostic factor in hepatocellular carcinoma.
Carcinoma, Squamous Cell
Genetic polymorphisms in the ITPKC gene and cervical squamous cell carcinoma risk.
Common Variable Immunodeficiency
Common variable immunodeficiency associated with microdeletion of chromosome 1q42.1-q42.3 and inositol 1,4,5-trisphosphate kinase B (ITPKB) deficiency.
Erythema
ITPKC and SLC11A1 Gene Polymorphisms and Gene-Gene Interactions in Korean Patients with Kawasaki Disease.
Glioma
Mining the glioma susceptibility genes in children from gene expression profiles and a methylation database.
Hirschsprung Disease
Potential association between ITPKC genetic variations and Hirschsprung disease.
Immune System Diseases
New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B.
Influenza, Human
Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs.
inositol-trisphosphate 3-kinase deficiency
Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways.
Lung Neoplasms
Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells.
Lung Neoplasms
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Lung Neoplasms
Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A.
Lung Neoplasms
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
Lung Neoplasms
ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.
Lung Neoplasms
The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells.
Mucocutaneous Lymph Node Syndrome
A functional polymorphism, rs28493229, in ITPKC and risk of Kawasaki disease: an integrated meta-analysis.
Mucocutaneous Lymph Node Syndrome
A replication study for association of ITPKC and CASP3 two-locus analysis in IVIG unresponsiveness and coronary artery lesion in Kawasaki disease.
Mucocutaneous Lymph Node Syndrome
Clinical Implication of the C Allele of the ITPKC Gene SNP rs28493229 in Kawasaki Disease: Association With Disease Susceptibility and BCG Scar Reactivation.
Mucocutaneous Lymph Node Syndrome
ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease.
Mucocutaneous Lymph Node Syndrome
ITPKC and SLC11A1 Gene Polymorphisms and Gene-Gene Interactions in Korean Patients with Kawasaki Disease.
Mucocutaneous Lymph Node Syndrome
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.
Mucocutaneous Lymph Node Syndrome
ITPKC gene SNP rs28493229 and Kawasaki disease in Taiwanese children.
Mucocutaneous Lymph Node Syndrome
ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.
Mucocutaneous Lymph Node Syndrome
ITPKC susceptibility in Kawasaki syndrome as a sensitizing factor for autoimmunity and coronary arterial wall relaxation induced by thimerosal's effects on calcium signaling via IP3.
Mucocutaneous Lymph Node Syndrome
PPP3CC feedback regulates IP3-Ca2+ pathway through preventing ITPKC degradation.
Mucocutaneous Lymph Node Syndrome
Single-nucleotide Polymorphism rs2290692 in the 3'UTR of ITPKC Associated With Susceptibility to Kawasaki Disease in a Han Chinese Population.
Mucocutaneous Lymph Node Syndrome
Single-Nucleotide Polymorphism rs7251246 in ITPKC Is Associated with Susceptibility and Coronary Artery Lesions in Kawasaki Disease.
Mucocutaneous Lymph Node Syndrome
Superantigen involvement and susceptibility factors in Kawasaki disease: profiles of TCR V?2+ T cells and HLA-DRB1, TNF-? and ITPKC genes among Filipino patients.
Mucocutaneous Lymph Node Syndrome
[Association study of a functional SNP rs28493229 of ITPKC gene and Kawasaki disease in a Chinese population].
Neoplasm Metastasis
Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.
Neoplasm Metastasis
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
Neoplasms
Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells.
Neoplasms
Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.
Neoplasms
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Neoplasms
Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A.
Neoplasms
Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.
Neoplasms
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
Neoplasms
Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance.
Neoplasms
ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.
Neoplasms
The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin.
Neoplasms
The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells.
Nephrolithiasis
Study of the association between ITPKC genetic polymorphisms and calcium nephrolithiasis.
Neuroblastoma
Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology.
Osteosarcoma
miR-140-5p attenuates chemotherapeutic drug induced cell death by regulating autophagy through IP3k2 in human osteosarcoma cells.
Parkinson Disease
ITPKB and ZNF184 are associated with Parkinson's disease risk in East Asians.
Small Cell Lung Carcinoma
The Expression of miR-375 Is Associated with Carcinogenesis in Three Subtypes of Lung Cancer.
Uterine Cervical Neoplasms
Genetic polymorphisms in the ITPKC gene and cervical squamous cell carcinoma risk.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0002
1D-myo-inositol 1,4,5-trisphosphate
-
pH 7.5, 30°C, recombinant, catalytically active fragment of isoform C
0.0002
1D-myo-inositol 1,4,5-trisphosphate
-
recombinant catalytic/CaM binding domain, pH 7.5, 30°C
0.00021
1D-myo-inositol 1,4,5-trisphosphate
-
pH 7.1, 30°C, addition of Ca2+/calmodulin increases the Km 2fold
0.0004
1D-myo-inositol 1,4,5-trisphosphate
-
recombinant wild-type catalytic/CaM binding domain, pH 7.5, 30°C
0.0004
1D-myo-inositol 1,4,5-trisphosphate
-
recombinant enzyme fragment comprising calmodulin binding domain
0.00047
1D-myo-inositol 1,4,5-trisphosphate
-
recombinant mutant K268E catalytic/CaM binding domain, pH 7.5, 30°C
0.00054
1D-myo-inositol 1,4,5-trisphosphate
-
recombinant mutant K272D catalytic/CaM binding domain, pH 7.5, 30°C
0.00056
1D-myo-inositol 1,4,5-trisphosphate
-
pH 7.2, 37°C, in presence or absence of 50 nM calmodulin
0.0017
1D-myo-inositol 1,4,5-trisphosphate
-
recombinant catalytic binding domain, pH 7.5, 30°C
0.002 - 0.005
1D-myo-inositol 1,4,5-trisphosphate
-
pH 7.5, 37°C, recombinant isoenzymes A and B
0.0021
1D-myo-inositol 1,4,5-trisphosphate
-
recombinant IP3K, in absence of Ca2+/calmodulin, 37°C
0.011
1D-myo-inositol 1,4,5-trisphosphate
-
pH 7.5, 37°C, in absence of 2,3-bisphosphoglycerate
0.0015
1D-myo-inositol 2,4,5-trisphosphate
-
pH 7.5, 30°C, in absence of Ca2+/calmodulin, recombinant, catalytically active fragment of isoform C
0.005
1D-myo-inositol 2,4,5-trisphosphate
-
pH 7.5, 30°C, in presence of 100 nM Ca2+/calmodulin, recombinant, catalytically active fragment of isoform C
0.033
ATP
-
pH 7.5, 30°C, in absence of Ca2+/calmodulin, recombinant, catalytically active fragment of isoform C
0.033
ATP
recombinant enzyme IP3K-C fragment comprising calmodulin binding domain and catalytic domain
0.042
ATP
recombinant enzyme IP3K-C fragment comprising catalytic domain
0.052
ATP
-
pH 7.5, 30°C, in presence of 100 nM Ca2+/calmodulin, recombinant, catalytically active fragment of isoform C
0.085
ATP
-
recombinant mutant K268E catalytic/CaM binding domain, pH 7.5, 30°C
0.105
ATP
-
recombinant mutant K272D catalytic/CaM binding domain, pH 7.5, 30°C
0.0002
InsP3
recombinant enzyme IP3K-C fragment comprising calmodulin binding domain and catalytic domain
0.0017
InsP3
recombinant enzyme IP3K-C fragment comprising catalytic domain
additional information
additional information
-
All potent inhibitors increases the KM-value for ATP
-
additional information
additional information
All potent inhibitors increases the KM-value for ATP
-
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000059
epigallocatechin-3-gallate
-
IP3K-A, mixed-type with respect to ATP; IP3K-A, non-competitive with respect to Ins(1,4,5)P3
additional information
additional information
-
dose-response curve of antiproliferative synthetic and plant polyphenolics inhibition
-
0.0001
aurintricarboxylic acid
-
IP3K-A, non-competitive with respect to Ins(1,4,5)P3
0.000043
epicatechin-3-gallate
-
IP3K-A, non-competitive with respect to Ins(1,4,5)P3
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.156
(2'S)-1D-1,2-O-[(2'-phosphoryloxy)propane-1',3'-diyl]-myo-inositol 4,5-bisphosphate
Rattus norvegicus
-
synthetic bicyclic inositol trisphosphate S epimer, IC50 is 0.156 mM
0.013
1D-myo-inositol 1,3,4,5-tetrakisphosphate
Rattus norvegicus
-
product inhibition, IC50 is 0.013 mM
0.036
7-methylsulfanyl-3-phenyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one
Homo sapiens
-
pH 7.5, 30°C, recombinant enzyme
0.0054
D-2-deoxyinositol 1,3,4,5-tetrakisphosphate
Rattus norvegicus
-
strong inhibition of isozyme A, IC50 is 0.0054 mM
0.0017
D-2-deoxyinositol 1,4,5-trisphosphate
Rattus norvegicus
-
strong inhibition of isozyme A, IC50 is 0.0017 mM
0.0014
D-3-deoxyinositol 1,4,6-trisphosphate
Rattus norvegicus
-
strong inhibition of isozyme A, IC50 is 0.0014 mM
0.0051
D-6-deoxyinositol 1,3,4,5-tetrakisphosphate
Rattus norvegicus
-
strong inhibition of isozyme A, IC50 is 0.0051 mM
0.003
D-myo-inositol 1,4,5-trisphosphate
Rattus norvegicus
-
strong inhibition, purified recombinant enzyme, IC50 value is 0.003 mM in absence of Ca2+
0.1
D-scyllo-inositol 1,2,3,4-tetrakisphosphate
Rattus norvegicus
-
purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+
0.044
D-scyllo-inositol 1,2,4-trisphosphate
Rattus norvegicus
-
purified recombinant enzyme, IC50 value is 0.044 mM in absence of Ca2+
0.1
L-scyllo-inositol 1,2,3,4-tetrakisphosphate
Rattus norvegicus
-
purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+
0.006
L-scyllo-inositol 1,2,4-trisphosphate
Rattus norvegicus
-
purified recombinant enzyme, IC50 value is 0.006 mM in absence of Ca2+
0.037
N-(1,2-benzoxazol-3-yl)-4-methylbenzamide
Homo sapiens
-
pH 7.5, 30°C, recombinant enzyme
0.017
N-(4-ethoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboxamide
Homo sapiens
-
pH 7.5, 30°C, recombinant enzyme
0.028
scyllo-inositol 1,2,3,5-tetrakisphosphate
Rattus norvegicus
-
weak inhibition, purified recombinant enzyme, IC50 value is 0.028 mM in absence of Ca2+
0.027
scyllo-inositol 1,2,3-trisphosphate
Rattus norvegicus
-
purified recombinant enzyme, IC50 value is 0.027 mM in absence of Ca2+
0.039
scyllo-inositol 1,2,4,5-tetrakisphosphate
Rattus norvegicus
-
weak inhibition, purified recombinant enzyme, IC50 value is 0.039 mM in absence of Ca2+
0.09
scyllo-inositol 1,3,5-trisphosphate
Rattus norvegicus
-
purified recombinant enzyme, IC50 value is 0.090 mM in absence of Ca2+
0.00019
3',4',7,8-tetrahydroxyflavone
Rattus norvegicus
Q80ZG2
IP3K-C, maximal inhibition 75%; recombinant enzyme IP3K-C fragment comprising calmodulin binding and catalytic domain
0.00029
3',4',7,8-tetrahydroxyflavone
Gallus gallus
-
IP3K-A, maximal inhibition 97%; recombinant enzyme fragment comprising calmodulin binding domain
0.00061
3',4',7,8-tetrahydroxyflavone
Rattus norvegicus
Q80ZG2
recombinant enzyme IP3K-C fragment comprising catalytic domain
additional information
F-actin
Homo sapiens
P23677
the full length form of inositol 1,4,5-trisphosphate-3-kinase-A bundles F-actin in a concentration dependent manner, inhibition of the initial rate of gelsolin induces F-actin severing and the degree of bundling are half maximal at an similar concentration of about 300 nM, whereas inhibition of the rate of actin depolymerization after dilution to 100 nM actin is half maximal at about 30 nM, the much lower EC 50 for the latter effect may reflect the high affinity of enzyme for binding to F actin
-
additional information
additional information
Rattus norvegicus
Q80ZG2
RnIP3K-C including the calmodulin binding and the catalytic domain shows a 3-fold lower IC50 value for 3',4',7,8-tetrahydroxyflavone than RnIP3K including only the calmodulin binding domain. The maximum degree of inhibition is unchanged. Together with the finding that Ca2+-calmodulin partly reverses IP3K inhibition indicates a facilitating but not essential involvement of the calmodulin binding domain in inhibitor binding.
-
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.0026
-
recombinant enzyme in the first particulate fraction of transfected COS-7 cells
1.7
-
pH 7.4, 37°C, purified recombinant isoenzyme A overexpressed in CHO cells
15
16
20
-
recombinant IP3K overexpressed in Escherichia coli, in absence of calmodulin
additional information
3
IP3K-C, recombinant enzyme fragment comprising calmodulin binding and catalytic domain
additional information
activity of ITPKA is reduced by 94-95% in H1299 knock-down cells as compared to controls; high ITPKA activity can significantly reduce the concentration of the 1D-myo-inositol 1,4,5-trisphosphate signal by rapidly removing the Ca2+ releasing second messenger
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.2
7.4
7.5
7.5
-
assay at
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.8 - 7.7
-
optimum pH range, increase from 75% of maximal activity at pH 5.8 to 100% at pH 7.7
6 - 8
-
steep increase in activity on raising pH from pH 6 to an optimum around pH 8
6.5 - 8
-
inactive at pH 6.5 and below, above pH 6.5 the activity rises steeply to a broad optimum at pH 8
7 - 9
-
about half-maximal activity at pH 7 and about 60% of maximal activity at pH 9
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30
37
37
-
assay at
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
3 isoenzymes: A and B, brain, and high-molecular weight platelet isoenzyme
-
-
brenda
wild-type strain C57BL/6 and enzyme-deficient strain, 3 isozymes IP3-3KA, IP3-3KB, and IP3-3KC
-
-
brenda
-
-
-
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
inositol trisphosphate 3-kinase B gene is expressed in all hematopoietic stem/progenitor cell populations
brenda
-
non-differentiated promyelocytic-leukaemia cell line, InsP3 3-kinase B mRNA
brenda
Itpkb protein level is increased upon differentiation of human embryonic stem cells
brenda
additional information
-
highest expression of recombinant isoenzyme A in astrocytes of hippocampal cultures transfected with isoenzyme A
brenda
; Itpka is particularly active in neurons of the hippocampus and cerebellum; Itpkb protein level is increased in the cerebral cortex of most patients with Alzheimer's disease compared with control subjects
brenda
-
Itpka is particularly active in neurons of the hippocampus and cerebellum
brenda
-
cortex; isoenzyme A is the major isoform present in neuronal cells
brenda
-
-
brenda
-
Itpka is particularly active in neurons of the hippocampus and cerebellum
brenda
cloning and expression in Escherichia coli; cloning and expression in Escherichia coli
brenda
Enzymes and their fragments expressed in Escherichia coli.
brenda
-
tracheal and bronchial, multiciliated tracheal epithelial cells
brenda
-
enzyme expression is highly enriched in the central nucleus of the amygdala
brenda
-
enzyme expression is highly enriched in the central nucleus of the amygdala
-
brenda
-
endogenous isoenzyme A is localized to the dentritic spines of pyramidal neurons in primary hippocampal cultures from neonatal rats, highest expression of recombinant isoenzyme A in astrocytes
brenda