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ATP + 1D-myo-inositol 1,4,5-triphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
ATP + 1D-myo-inositol 2,4,5-trisphosphate
ADP + 1D-myo-inositol 2,4,5,6-tetrakisphosphate
-
recombinant, catalytically active fragment of isoform C, in the presence of Ins(1,3,4,5)P4, authentic side activity of isoform C
-
?
ATP + D-2-deoxy-myo-inositol 1,4,5-trisphosphate
ADP + D-2-deoxy-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
additional information
?
-
ATP + 1D-myo-inositol 1,4,5-trisphosphate

ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
specific for phosphorylation of the 3-position
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
target enzyme of cellular regulation, enzyme controls the rate of InsP3 metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
role in limiting the availability of InsP3 for Ca2+ release in smooth muscle relaxation
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
important alternative route for inositol 1,4,5-trisphosphate metabolism in skeletal muscle
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulatory mechanism of isoenzyme B involving phosphorylation by both protein kinase C and CaM kinase II
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulation mechanism of isoenzyme A involving CaM kinase II-mediated phosphorylation
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
role of the 3 isoforms as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulation mechanism of isoenzyme A in brain involving CaM kinase II-mediated phosphorylation, role of Ins(1,4,5)P3 3-kinase in brain
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
key enzyme in inositol phosphate signaling pathway
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
substrate and product binding site structure
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
role in rapidly metabolizing the pool of Ins(1,4,5)P3 that is generated when phospholipase C-coupled receptors are activated, the product Ins(1,3,4,5)P4 can protect Ins(1,4,5)P3 against hydrolysis and therefore increase its effectiveness, detailed consequences of Ins(1,3,4,5)P4 generation in the cell, all 3 isoenzymes are regulated by calmodulin, 2 isoenzymes are regulated by a Ca2+/calmodulin-dependent protein kinase II
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
enzyme phosphorylates the 3'-position of the inositol ring to convert the substrate to the product
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
multiple regulation mechanisms of enzyme isoform A and B
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
domain structure of IP3K-C
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulatory mechanism of isoenzyme B involving phosphorylation by both protein kinase C and CaM kinase II
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulation mechanism of isoenzyme A involving CaM kinase II-mediated phosphorylation
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
environment of the active site, proposed binding site model for Ins(1,4,5)P3
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
also phosphorylates the 1,2-cyclic form of myo-inositol 1,4,5-trisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
specific for phosphorylation of the 3-position
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
specific for phosphorylation of the 3-position
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
enzyme is specific for phosphorylating the position 3 of the myo-inositol ring and requires vicinal phosphates in the 4 and 5 positions
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
isoform A: N-terminal 66-amino acid F-actin-binding region
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
differential expression and regulation of the two enzyme isoforms A and B provides multiple mechanisms for regulating the cytosolic level of inositol 1,4,5-trisphosphate in cells, regulation mechanisms
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate have separate second messenger roles, perhaps both relating to Ca2+-signaling events
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
phosphorylation of IP3 in dentritic spines to produce IP4 is important for modulating the compartmentalization of calcium at synapses, control of calcium signals, the rapid, localized synthesis of IP4 may have complex effects on cytosolic calcium and on the molecular mechanisms that control learning and memory
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
IP3K regulates the intracellular level of the 2 second messengers Ins(1,4,5)P3 and Ins(1,3,4,5)P4
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulation mechanism of isoenzyme A in brain involving CaM kinase II-mediated phosphorylation, role of Ins(1,4,5)P3 3-kinase in brain
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
IP3K isoform C: nucleocytoplasmic shuttling, particular role in nuclear inositol trisphosphate phosphorylation and cellular growth, enzyme seems to function during the intervalls between signaling events, keeps the resting Ins(1,4,5)P3 very low and provides a basal Ins(1,3,4,5)P4 production in the absence of stimulatory signals from the exterior
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
enzyme occupies a central position in inositol phosphate metabolism by terminating the Ca2+ mobilizing of InsP3 and by generating InsP4
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol tris/tetrakisphosphate pathway
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
isoform B may play a significant role in the regulation of Ins(1,4,5)P3 levels, and consequently in Ca2+ responses following stimulation of cells with Ins(1,4,5)P3-elevating agonists
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate mobilizes Ca2+ from the intracellular stores of permeabilized cells, enzyme is Ca2+-regulated
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
important regulatory role in inositol phosphate signaling by promoting the formation of additional inositol polyphosphate isomers
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate 3-kinase reaction of the inositol polyphosphate multikinase, EC 2.7.1.151
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
InsP3K activity is a determinant of the extent of basal Ras activation in mast cells and of the Ras activation that follows antigenic crosslinking of the FcepsilonRI
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate 3-kinase reaction of the inositol polyphosphate multikinase, EC 2.7.1.151
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate 3-kinase reaction of the inositol polyphosphate multikinase, EC 2.7.1.151
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involvement of a calmodulin-dependent protein kinase II-mediated phosphorylation in enzyme regulation, enzyme decreases the Ins(1,4,5)P3 concentration, this second messenger binds to the InsP3 receptor to release Ca2+ from intracellular stores, the activation of enzyme may be involved in the Ca2+-dependent down regulation of the InsP3-mediated Ca2+ release, enzyme may play a key role in regulating signals arising from the phospholipase C-related transduction system
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
additional information

?
-
-
the enzyme might be involved in oxidative damage resistance
-
?
additional information
?
-
-
the 3 isoenzymes A, B and C can be distinguished by their N-terminal sequence, sensitivity to Ca2+/calmodulin and localization on transfection in COS-7 cells
-
?
additional information
?
-
-
the enzyme might be involved in brain development, memory, and learning
-
?
additional information
?
-
-
the enzyme binds to F-actin in the cellular actin cytoskeleton with its F-actin domain at the N-terminus, the C-terminal fragment cannot bind to F-actin
-
?
additional information
?
-
-
isozyme B controls positive selection of T cells and modulates Erk activity, the enzyme is important in Ras signaling which is important for Erk activation, overview
-
?
additional information
?
-
-
isozyme B controls positive selection of T cells and modulates Erk activity, the enzyme is important in Ras signaling which is important for Erk activation, overview
-
?
additional information
?
-
-
not: GTP, 5'-guanylylimidodiphosphate
-
?
additional information
?
-
-
the enzyme might be involved in brain development, memory, and learning
-
?
additional information
?
-
the enzyme binds to F-actin in the cellular actin cytoskeleton with its F-actin domain at the N-terminus, the C-terminal fragment cannot bind to F-actin
-
?
additional information
?
-
-
the enzyme contains a catalytic domain and a 4-helix substrate binding domain, both are in an open conformation with respect to each other, thus substrate recognition and catalysis involve a dynamic conformational cycle
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 1D-myo-inositol 1,4,5-triphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
additional information
?
-
ATP + 1D-myo-inositol 1,4,5-trisphosphate

ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
target enzyme of cellular regulation, enzyme controls the rate of InsP3 metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
role in limiting the availability of InsP3 for Ca2+ release in smooth muscle relaxation
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
important alternative route for inositol 1,4,5-trisphosphate metabolism in skeletal muscle
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
r
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulatory mechanism of isoenzyme B involving phosphorylation by both protein kinase C and CaM kinase II
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
role of the 3 isoforms as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulation mechanism of isoenzyme A in brain involving CaM kinase II-mediated phosphorylation, role of Ins(1,4,5)P3 3-kinase in brain
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
key enzyme in inositol phosphate signaling pathway
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
role in rapidly metabolizing the pool of Ins(1,4,5)P3 that is generated when phospholipase C-coupled receptors are activated, the product Ins(1,3,4,5)P4 can protect Ins(1,4,5)P3 against hydrolysis and therefore increase its effectiveness, detailed consequences of Ins(1,3,4,5)P4 generation in the cell, all 3 isoenzymes are regulated by calmodulin, 2 isoenzymes are regulated by a Ca2+/calmodulin-dependent protein kinase II
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
enzyme phosphorylates the 3'-position of the inositol ring to convert the substrate to the product
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulatory mechanism of isoenzyme B involving phosphorylation by both protein kinase C and CaM kinase II
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
differential expression and regulation of the two enzyme isoforms A and B provides multiple mechanisms for regulating the cytosolic level of inositol 1,4,5-trisphosphate in cells, regulation mechanisms
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate have separate second messenger roles, perhaps both relating to Ca2+-signaling events
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
phosphorylation of IP3 in dentritic spines to produce IP4 is important for modulating the compartmentalization of calcium at synapses, control of calcium signals, the rapid, localized synthesis of IP4 may have complex effects on cytosolic calcium and on the molecular mechanisms that control learning and memory
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
IP3K regulates the intracellular level of the 2 second messengers Ins(1,4,5)P3 and Ins(1,3,4,5)P4
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
regulation mechanism of isoenzyme A in brain involving CaM kinase II-mediated phosphorylation, role of Ins(1,4,5)P3 3-kinase in brain
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
IP3K isoform C: nucleocytoplasmic shuttling, particular role in nuclear inositol trisphosphate phosphorylation and cellular growth, enzyme seems to function during the intervalls between signaling events, keeps the resting Ins(1,4,5)P3 very low and provides a basal Ins(1,3,4,5)P4 production in the absence of stimulatory signals from the exterior
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
enzyme occupies a central position in inositol phosphate metabolism by terminating the Ca2+ mobilizing of InsP3 and by generating InsP4
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol tris/tetrakisphosphate pathway
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
isoform B may play a significant role in the regulation of Ins(1,4,5)P3 levels, and consequently in Ca2+ responses following stimulation of cells with Ins(1,4,5)P3-elevating agonists
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate mobilizes Ca2+ from the intracellular stores of permeabilized cells, enzyme is Ca2+-regulated
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
important regulatory role in inositol phosphate signaling by promoting the formation of additional inositol polyphosphate isomers
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol phosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
InsP3K activity is a determinant of the extent of basal Ras activation in mast cells and of the Ras activation that follows antigenic crosslinking of the FcepsilonRI
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
inositol 1,4,5-trisphosphate is a second messenger
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involvement of a calmodulin-dependent protein kinase II-mediated phosphorylation in enzyme regulation, enzyme decreases the Ins(1,4,5)P3 concentration, this second messenger binds to the InsP3 receptor to release Ca2+ from intracellular stores, the activation of enzyme may be involved in the Ca2+-dependent down regulation of the InsP3-mediated Ca2+ release, enzyme may play a key role in regulating signals arising from the phospholipase C-related transduction system
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
involved in inositol polyphosphate metabolism
-
-
?
additional information

?
-
-
the enzyme might be involved in oxidative damage resistance
-
-
?
additional information
?
-
-
the enzyme might be involved in brain development, memory, and learning
-
-
?
additional information
?
-
-
isozyme B controls positive selection of T cells and modulates Erk activity, the enzyme is important in Ras signaling which is important for Erk activation, overview
-
-
?
additional information
?
-
-
isozyme B controls positive selection of T cells and modulates Erk activity, the enzyme is important in Ras signaling which is important for Erk activation, overview
-
-
?
additional information
?
-
-
the enzyme might be involved in brain development, memory, and learning
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2'S)-1D-1,2-O-[(2'-phosphoryloxy)propane-1',3'-diyl]-myo-inositol 4,5-bisphosphate
-
synthetic bicyclic inositol trisphosphate S epimer, IC50 is 0.156 mM
1D-myo-inositol 1,3,4,5-tetrakisphosphate
1D-myo-inositol 1,4,5-trisphosphate
2,3-diphosphoglycerate
-
-
3',4',7,8-tetrahydroxyflavone
7-methylsulfanyl-3-phenyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one
55% inhibition at 0.04 mM
D-2-deoxyinositol 1,3,4,5-tetrakisphosphate
-
strong inhibition of isozyme A, IC50 is 0.0054 mM
D-2-deoxyinositol 1,4,5-trisphosphate
-
strong inhibition of isozyme A, IC50 is 0.0017 mM
D-3-deoxyinositol 1,4,6-trisphosphate
-
strong inhibition of isozyme A, IC50 is 0.0014 mM
D-6-deoxyinositol 1,3,4,5-tetrakisphosphate
-
strong inhibition of isozyme A, IC50 is 0.0051 mM
D-myo-inositol 1,4,5-trisphosphate
-
strong inhibition, purified recombinant enzyme, IC50 value is 0.003 mM in absence of Ca2+
D-myo-inositol 2,4,5-trisphosphate
-
IC50 is 0.117 mM
D-scyllo-inositol 1,2,3,4-tetrakisphosphate
-
purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+
D-scyllo-inositol 1,2,4-trisphosphate
-
purified recombinant enzyme, IC50 value is 0.044 mM in absence of Ca2+
epigallocatechin-3-gallate
heparin
-
mixed-type inhibition
inositol phosphate
-
inhibitory effects of all possible 38 regioisomers of synthetic inositol phosphates, only inositol trisphosphates and tetrakisphosphates inhibit, not or very weak: inositol monophosphates, bisphosphates and pentakisphosphates, the recognition of myo-inositol phosphate regioisomers is highly structure-selective
L-scyllo-inositol 1,2,3,4-tetrakisphosphate
-
purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+
L-scyllo-inositol 1,2,4-trisphosphate
-
purified recombinant enzyme, IC50 value is 0.006 mM in absence of Ca2+
N-(1,2-benzoxazol-3-yl)-4-methylbenzamide
68% inhibition at 0.04 mM, mixed type inhibitor, that is nearly completely taken up by H1299 cells and remains stable after cellular uptake, the compound exhibits a robust stability and a high membrane permeability. The inhibitor provides the possibility to partly inhibit the metastasis-promoting effect of ITPKA in lung tumor cells. Inhibition mechanism of BAMB-4, overview
N-(4-ethoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboxamide
87% inhibition at 0.04 mM
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide
protein kinase A
-
isoforms A and B are differentially regulated via phosphorylation by the cAMP-dependent protein kinase, isoform A: stimulation in the presence or absence of Ca2+/calmodulin, isoform B: no effect on activity in the absence of Ca2+/calmodulin, 45% inhibition in the presence of Ca2+/calmodulin
-
RS-20
-
calmodulin antagonist, prevents the Ca2+/calmodulin-mediated activation
-
scyllo-inositol 1,2,3,5-tetrakisphosphate
-
weak inhibition, purified recombinant enzyme, IC50 value is 0.028 mM in absence of Ca2+
scyllo-inositol 1,2,3-trisphosphate
-
purified recombinant enzyme, IC50 value is 0.027 mM in absence of Ca2+
scyllo-inositol 1,2,4,5-tetrakisphosphate
-
weak inhibition, purified recombinant enzyme, IC50 value is 0.039 mM in absence of Ca2+
scyllo-inositol 1,3,5-trisphosphate
-
purified recombinant enzyme, IC50 value is 0.090 mM in absence of Ca2+
TSH
-
thyroid-stimulating hormone, inhibits at a physiological concentration, inhibition is mimicked by dibuturyl cyclic AMP and forskolin, mechanism
1D-myo-inositol 1,3,4,5-tetrakisphosphate

-
marked product inhibition, isoforms A and B
1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
product inhibition, IC50 is 0.013 mM
1D-myo-inositol 1,4,5-trisphosphate

-
substrate inhibition of the catalytic domain
1D-myo-inositol 1,4,5-trisphosphate
-
recombinant, catalytically active fragment of isoform C, substrate inhibition by high concentrations
3',4',7,8-tetrahydroxyflavone

-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
3',4',7,8-tetrahydroxyflavone
-
the point mutant K336Q reveals a drastically reduced inhibition by THF. Substitution of Lys336 leads to a 260fold increase in the IC50. On the other hand, kinetic parameters of the enzyme with respect to both substrates are nearly unchanged. This region shows high homology between IP3K isoforms.
3',4',7,8-tetrahydroxyflavone
-
inhibition of isozyme A, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
3',4',7,8-tetrahydroxyflavone
-
3',4',7,8-tetrahydroxyflavone
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
3',4',7,8-tetrahydroxyflavone
-
aurintricarboxylic acid

-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
aurintricarboxylic acid
-
-
aurintricarboxylic acid
-
inhibition of isozyme A and isozyme B, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
aurintricarboxylic acid
-
aurintricarboxylic acid
-
strong inhibition, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
aurintricarboxylic acid
-
Ca2+

-
-
Ca2+
-
at concentrations higher than 0.01-0.1 mM
Ca2+
-
at higher concentrations
Ca2+
-
isoforms A and B, above 0.01 mM
chlorogenic acid

-
-
chlorpromazine

-
calmodulin-antagonist, inhibits Ca2+-activated enzyme activity
chlorpromazine
-
calmodulin-antagonist, inhibits Ca2+-activated enzyme activity
EGTA

-
Ca2+/calmodulin-activated enzyme
EGTA
-
Ca2+/calmodulin-activated enzyme
EGTA
-
Ca2+/calmodulin-activated enzyme
EGTA
-
Ca2+/calmodulin-activated enzyme
ellagic acid

-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
ellagic acid
-
inhibition of isozyme B, slight inhibition of isozyme A, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
epicatechin-3-gallate

-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
epicatechin-3-gallate
-
-
epicatechin-3-gallate
-
slight inhibition of isozyme A and isozyme B, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
epicatechin-3-gallate
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-triphosphate
epigallocatechin-3-gallate

-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
epigallocatechin-3-gallate
-
-
epigallocatechin-3-gallate
-
inhibition of isozyme A, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
epigallocatechin-3-gallate
-
epigallocatechin-3-gallate
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-triphosphate
epigallocatechin-3-gallate
-
gossypol

-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
gossypol
-
inhibition of isozyme A and isozyme B, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
gossypol
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
hypericin

-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
hypericin
-
inhibition of isozyme A and isozyme B, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
hypericin
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-triphosphate
KN-62

-
calmodulin-dependent protein kinase II inhibitor; prevents the carbachol- or UTP-mediated activation
KN-62
-
calmodulin-dependent protein kinase II inhibitor; prevents the carbachol- or UTP-mediated activation
KN-62
-
calmodulin-dependent protein kinase II inhibitor; prevents the Ca2+/calmodulin-mediated activation
KN-93

-
calmodulin-dependent protein kinase II inhibitor; prevents the carbachol- or UTP-mediated activation
KN-93
-
calmodulin-dependent protein kinase II inhibitor; prevents the carbachol- or UTP-mediated activation
KN-93
-
calmodulin-dependent protein kinase II inhibitor; prevents the Ca2+/calmodulin-mediated activation
myricetin

-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
myricetin
-
inhibition of isozyme A, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
myricetin
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide

-
i.e. W-7, calmodulin-antagonist; inhibits Ca2+-activated enzyme activity
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide
-
i.e. W-7, calmodulin-antagonist
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide
-
i.e. W-7, calmodulin-antagonist; inhibits Ca2+-activated enzyme activity
Protein kinase C

-
phosphorylates and inactivates enzyme
-
Protein kinase C
-
phosphorylates and inactivates enzyme
-
Protein kinase C
-
negative regulatory function, phosphorylates the enzyme at a serine residue
-
Protein kinase C
-
protein kinase C alone, without CaM kinase II, inhibits in the presence of Ca2+ and calmodulin
-
Protein kinase C
-
isoforms A and B are differentially regulated via phosphorylation by protein kinase C, isoform A: phosphorylated to the extent of 2 mol/mol, 72% inhibition in the absence of Ca2+/calmodulin, isoform B: phosphorylated to the extent of 2.7 mol/mol, no effect on activity in the absence of Ca2+/calmodulin, both isoforms are inhibited by 70% in the presence of Ca2+/calmodulin
-
Protein kinase C
-
negative regulatory function, phosphorylates the enzyme at Ser175, simultaneous phosphorylation at Ser109 and Ser175 also inactivates the enzyme
-
Protein kinase C
-
negative regulatory function, phosphorylates the enzyme at a Ser residue
-
quercetin

-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
quercetin
-
inhibition of isozyme A, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
quercetin
-
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
Rose bengal

-
-
Rose bengal
-
slight inhibition of isozyme B, mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate
SDS

-
complete inhibition at 0.1%, 1% Triton X-100 partially reverses
additional information

-
IC50 values, overiew, the inhibition by the synthetic or plant phenols can in some cases be partially or completely reversed by Triton X-100, no inhibition by chlorogenic acid and by Rose Bengal
-
additional information
-
All inhibitors display a mixed-type inhibition with respect to ATP and a noncompetitive inhibition with respect to 1D-myo-inositol 1,4,5-triphosphate. Mutagenesis studies reveal that both the calmodulin binding and the ATP binding domains in IP3K are involved in inhibitor binding. Most discovered potent IP3K inhibitors exert antiproliferative effects on cultured cells in vitro or in animal experiments and tumor treatment studies in vivo.; Reversal of enzyme inhibition by addition of Triton X-100 and Ca2+-calmodulin.
-
additional information
-
IC50 values, overiew, inhibitory potency of the synthetic and plant phenolics, no inhibition by chlorogenic acid
-
additional information
All inhibitors display a mixed-type inhibition with respect to ATP and a noncompetitive inhibition with respect to inositol-1,4,5-trisphosphate. Mutagenesis studies reveal that both the calmodulin binding and the ATP binding domains in IP3K are involved in inhibitor binding. Most discovered potent IP3K inhibitors exert antiproliferative effects on cultured cells in vitro or in animal experiments and tumor treatment studies in vivo.; All inhibitors display a mixed-type inhibition with respect to ATP and a noncompetitive inhibition with respect to Ins(1,4,5)P3. Mutagenesis studies reveal that both the calmodulin binding and the ATP binding domains in IP3K are involved in inhibitor binding. Most discovered potent IP3K inhibitors exert antiproliferative effects on cultured cells in vitro or in animal experiments and tumor treatment studies in vivo.
-
additional information
All inhibitors display a mixed-type inhibition with respect to ATP and a noncompetitive inhibition with respect to inositol-1,4,5-trisphosphate. Mutagenesis studies reveal that both the calmodulin binding and the ATP binding domains in IP3K are involved in inhibitor binding. Most discovered potent IP3K inhibitors exert antiproliferative effects on cultured cells in vitro or in animal experiments and tumor treatment studies in vivo.; All inhibitors display a mixed-type inhibition with respect to ATP and a noncompetitive inhibition with respect to Ins(1,4,5)P3. Mutagenesis studies reveal that both the calmodulin binding and the ATP binding domains in IP3K are involved in inhibitor binding. Most discovered potent IP3K inhibitors exert antiproliferative effects on cultured cells in vitro or in animal experiments and tumor treatment studies in vivo.
-
additional information
in order to inhibit the metastasis-promoting activity of ITPKA, both its actin bundling and its InsP3kinase activity has to be blocked, inhibitor library screening, overview
-
additional information
-
not inhibited by GTP or 5'-guanylylimidodiphosphate
-
additional information
-
enzyme contains several motifs susceptible to a variety of proteases
-
additional information
-
inhibitor binding structures and mechanism, scyllo-inositol pentakisphosphate, scyllo-inositol hexakisphosphate, scyllo-inositol monophosphate, and scyllo-inositol S-bisphosphates are poor inhibitors
-
additional information
-
poor inhibition by adenophostin analogues xylo-furanophostin and furanophostin, by L-myo-inositol 2,4,5-trisphosphate, synthetic bicyclic inositol trisphosphate R epimer, and by epi-1D-myo-inositol 1,3,6-trisphosphate
-
additional information
-
IC50 values, overiew, no inhibition by chlorogenic acid, poor inhibition by rose bengal, and ellagic acid
-
additional information
All inhibitors display a mixed-type inhibition with respect to ATP and a noncompetitive inhibition with respect to 1D-myo-inositol 1,4,5-triphosphate. Mutagenesis studies reveal that both the calmodulin binding and the ATP binding domains in IP3K are involved in inhibitor binding. Most discovered potent IP3K inhibitors exert antiproliferative effects on cultured cells in vitro or in animal experiments and tumor treatment studies in vivo.; The flavonoids myricetin, 3',4',7,8-tetrahydroxyflavone, and epigallocatechin-3-gallate have a markedly stronger effect on isoforms A and C than on isoform B
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Adenocarcinoma
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Adenocarcinoma of Lung
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Adenocarcinoma of Lung
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
Adenocarcinoma of Lung
TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.
Alzheimer Disease
Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology.
Aneurysm
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.
Aneurysm
ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.
Aneurysm
Management of Kawasaki disease.
Aneurysm
Single-Nucleotide Polymorphism rs7251246 in ITPKC Is Associated with Susceptibility and Coronary Artery Lesions in Kawasaki Disease.
Arthritis
Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.
Autoimmune Diseases
Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.
Breast Neoplasms
Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.
Breast Neoplasms
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
Breast Neoplasms
ITPKC as a Prognostic and Predictive Biomarker of Neoadjuvant Chemotherapy for Triple Negative Breast Cancer.
Carcinogenesis
Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma.
Carcinogenesis
ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker inĀ Lung and Other Cancers.
Carcinoma
Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.
Carcinoma
Genetic polymorphisms in the ITPKC gene and cervical squamous cell carcinoma risk.
Carcinoma
ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker inĀ Lung and Other Cancers.
Carcinoma
The Expression of miR-375 Is Associated with Carcinogenesis in Three Subtypes of Lung Cancer.
Carcinoma
The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells.
Carcinoma, Hepatocellular
ITPKA expression is a novel prognostic factor in hepatocellular carcinoma.
Carcinoma, Squamous Cell
Genetic polymorphisms in the ITPKC gene and cervical squamous cell carcinoma risk.
Common Variable Immunodeficiency
Common variable immunodeficiency associated with microdeletion of chromosome 1q42.1-q42.3 and inositol 1,4,5-trisphosphate kinase B (ITPKB) deficiency.
Erythema
ITPKC and SLC11A1 Gene Polymorphisms and Gene-Gene Interactions in Korean Patients with Kawasaki Disease.
Glioma
Mining the glioma susceptibility genes in children from gene expression profiles and a methylation database.
Graft vs Host Disease
Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease.
Hirschsprung Disease
Potential association between ITPKC genetic variations and Hirschsprung disease.
Hodgkin Disease
Diagnostic utility of STAT6YE361 expression in classical Hodgkin lymphoma and related entities.
Immune System Diseases
New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B.
Influenza, Human
Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs.
inositol-trisphosphate 3-kinase deficiency
Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways.
Lung Neoplasms
Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells.
Lung Neoplasms
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Lung Neoplasms
Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A.
Lung Neoplasms
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
Lung Neoplasms
ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker inĀ Lung and Other Cancers.
Lung Neoplasms
TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.
Lung Neoplasms
The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells.
Mucocutaneous Lymph Node Syndrome
A functional polymorphism, rs28493229, in ITPKC and risk of Kawasaki disease: an integrated meta-analysis.
Mucocutaneous Lymph Node Syndrome
A replication study for association of ITPKC and CASP3 two-locus analysis in IVIG unresponsiveness and coronary artery lesion in Kawasaki disease.
Mucocutaneous Lymph Node Syndrome
Clinical Implication of the C Allele of the ITPKC Gene SNP rs28493229 in Kawasaki Disease: Association With Disease Susceptibility and BCG Scar Reactivation.
Mucocutaneous Lymph Node Syndrome
ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease.
Mucocutaneous Lymph Node Syndrome
ITPKC and SLC11A1 Gene Polymorphisms and Gene-Gene Interactions in Korean Patients with Kawasaki Disease.
Mucocutaneous Lymph Node Syndrome
ITPKC as a Prognostic and Predictive Biomarker of Neoadjuvant Chemotherapy for Triple Negative Breast Cancer.
Mucocutaneous Lymph Node Syndrome
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.
Mucocutaneous Lymph Node Syndrome
ITPKC gene SNP rs28493229 and Kawasaki disease in Taiwanese children.
Mucocutaneous Lymph Node Syndrome
ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.
Mucocutaneous Lymph Node Syndrome
ITPKC susceptibility in Kawasaki syndrome as a sensitizing factor for autoimmunity and coronary arterial wall relaxation induced by thimerosal's effects on calcium signaling via IP3.
Mucocutaneous Lymph Node Syndrome
Kawasaki disease: update on pathogenesis.
Mucocutaneous Lymph Node Syndrome
PPP3CC feedback regulates IP3-Ca2+ pathway through preventing ITPKC degradation.
Mucocutaneous Lymph Node Syndrome
Single-nucleotide Polymorphism rs2290692 in the 3'UTR of ITPKC Associated With Susceptibility to Kawasaki Disease in a Han Chinese Population.
Mucocutaneous Lymph Node Syndrome
Single-Nucleotide Polymorphism rs7251246 in ITPKC Is Associated with Susceptibility and Coronary Artery Lesions in Kawasaki Disease.
Mucocutaneous Lymph Node Syndrome
Superantigen involvement and susceptibility factors in Kawasaki disease: profiles of TCR V?2+ T cells and HLA-DRB1, TNF-? and ITPKC genes among Filipino patients.
Mucocutaneous Lymph Node Syndrome
[Association study of a functional SNP rs28493229 of ITPKC gene and Kawasaki disease in a Chinese population].
Neoplasm Metastasis
Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.
Neoplasm Metastasis
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
Neoplasms
DNA methylation profiling in nonfunctioning pituitary adenomas.
Neoplasms
Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells.
Neoplasms
Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.
Neoplasms
Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Neoplasms
Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A.
Neoplasms
Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.
Neoplasms
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.
Neoplasms
Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance.
Neoplasms
ITPKA expression is a novel prognostic factor in hepatocellular carcinoma.
Neoplasms
ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker inĀ Lung and Other Cancers.
Neoplasms
ITPKC as a Prognostic and Predictive Biomarker of Neoadjuvant Chemotherapy for Triple Negative Breast Cancer.
Neoplasms
Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma.
Neoplasms
Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice.
Neoplasms
TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.
Neoplasms
The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin.
Neoplasms
The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells.
Nephrolithiasis
Study of the association between ITPKC genetic polymorphisms and calcium nephrolithiasis.
Neuroblastoma
Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology.
Neuroblastoma
Tissue- and cell-specific expression of Ins(1,4,5)P3 3-kinase isoenzymes.
Osteosarcoma
miR-140-5p attenuates chemotherapeutic drug induced cell death by regulating autophagy through IP3k2 in human osteosarcoma cells.
Parkinson Disease
Association of ZNF184, IL1R2, LRRK2, ITPKB, and PARK16 with sporadic Parkinson's disease in Eastern China.
Parkinson Disease
ITPKB and ZNF184 are associated with Parkinson's disease risk in East Asians.
Severe Combined Immunodeficiency
Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency.
Small Cell Lung Carcinoma
The Expression of miR-375 Is Associated with Carcinogenesis in Three Subtypes of Lung Cancer.
Triple Negative Breast Neoplasms
ITPKC as a Prognostic and Predictive Biomarker of Neoadjuvant Chemotherapy for Triple Negative Breast Cancer.
Uterine Cervical Neoplasms
Genetic polymorphisms in the ITPKC gene and cervical squamous cell carcinoma risk.
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0.156
(2'S)-1D-1,2-O-[(2'-phosphoryloxy)propane-1',3'-diyl]-myo-inositol 4,5-bisphosphate
Rattus norvegicus
-
synthetic bicyclic inositol trisphosphate S epimer, IC50 is 0.156 mM
0.013
1D-myo-inositol 1,3,4,5-tetrakisphosphate
Rattus norvegicus
-
product inhibition, IC50 is 0.013 mM
0.00018 - 0.0843
3',4',7,8-tetrahydroxyflavone
0.036
7-methylsulfanyl-3-phenyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one
Homo sapiens
pH 7.5, 30°C, recombinant enzyme
0.000062 - 0.00015
aurintricarboxylic acid
0.0054
D-2-deoxyinositol 1,3,4,5-tetrakisphosphate
Rattus norvegicus
-
strong inhibition of isozyme A, IC50 is 0.0054 mM
0.0017
D-2-deoxyinositol 1,4,5-trisphosphate
Rattus norvegicus
-
strong inhibition of isozyme A, IC50 is 0.0017 mM
0.0014
D-3-deoxyinositol 1,4,6-trisphosphate
Rattus norvegicus
-
strong inhibition of isozyme A, IC50 is 0.0014 mM
0.0051
D-6-deoxyinositol 1,3,4,5-tetrakisphosphate
Rattus norvegicus
-
strong inhibition of isozyme A, IC50 is 0.0051 mM
0.003
D-myo-inositol 1,4,5-trisphosphate
Rattus norvegicus
-
strong inhibition, purified recombinant enzyme, IC50 value is 0.003 mM in absence of Ca2+
0.117
D-myo-inositol 2,4,5-trisphosphate
Rattus norvegicus
-
IC50 is 0.117 mM
0.1
D-scyllo-inositol 1,2,3,4-tetrakisphosphate
Rattus norvegicus
-
purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+
0.044
D-scyllo-inositol 1,2,4-trisphosphate
Rattus norvegicus
-
purified recombinant enzyme, IC50 value is 0.044 mM in absence of Ca2+
0.000036 - 0.00069
ellagic acid
0.000094 - 0.00056
epicatechin-3-gallate
0.00012 - 0.00278
epigallocatechin-3-gallate
0.000058 - 0.00034
gossypol
0.00017 - 0.00021
hypericin
0.1
L-scyllo-inositol 1,2,3,4-tetrakisphosphate
Rattus norvegicus
-
purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+
0.006
L-scyllo-inositol 1,2,4-trisphosphate
Rattus norvegicus
-
purified recombinant enzyme, IC50 value is 0.006 mM in absence of Ca2+
0.00015 - 0.0042
myricetin
0.037
N-(1,2-benzoxazol-3-yl)-4-methylbenzamide
Homo sapiens
pH 7.5, 30°C, recombinant enzyme
0.017
N-(4-ethoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboxamide
Homo sapiens
pH 7.5, 30°C, recombinant enzyme
0.00018 - 0.00125
quercetin
0.00017 - 0.00312
Rose bengal
0.028
scyllo-inositol 1,2,3,5-tetrakisphosphate
Rattus norvegicus
-
weak inhibition, purified recombinant enzyme, IC50 value is 0.028 mM in absence of Ca2+
0.027
scyllo-inositol 1,2,3-trisphosphate
Rattus norvegicus
-
purified recombinant enzyme, IC50 value is 0.027 mM in absence of Ca2+
0.039
scyllo-inositol 1,2,4,5-tetrakisphosphate
Rattus norvegicus
-
weak inhibition, purified recombinant enzyme, IC50 value is 0.039 mM in absence of Ca2+
0.09
scyllo-inositol 1,3,5-trisphosphate
Rattus norvegicus
-
purified recombinant enzyme, IC50 value is 0.090 mM in absence of Ca2+
additional information
chlorogenic acid
0.00018
3',4',7,8-tetrahydroxyflavone

Homo sapiens
-
0.00019
3',4',7,8-tetrahydroxyflavone
Rattus norvegicus
IP3K-C, maximal inhibition 75%
0.00019
3',4',7,8-tetrahydroxyflavone
Rattus norvegicus
recombinant enzyme IP3K-C fragment comprising calmodulin binding and catalytic domain
0.00029
3',4',7,8-tetrahydroxyflavone
Gallus gallus
-
IP3K-A, maximal inhibition 97%
0.00029
3',4',7,8-tetrahydroxyflavone
Gallus gallus
-
recombinant enzyme fragment comprising calmodulin binding domain
0.00061
3',4',7,8-tetrahydroxyflavone
Rattus norvegicus
recombinant enzyme IP3K-C fragment comprising catalytic domain
0.0034
3',4',7,8-tetrahydroxyflavone
Homo sapiens
-
0.0843
3',4',7,8-tetrahydroxyflavone
Gallus gallus
-
IP3K-A, K336Q mutant
0.000062
aurintricarboxylic acid

Rattus norvegicus
IP3K-C, maximal inhibition 100%
0.00011
aurintricarboxylic acid
Homo sapiens
-
0.000138
aurintricarboxylic acid
Homo sapiens
-
0.00015
aurintricarboxylic acid
Gallus gallus
-
IP3K-A, maximal inhibition 100%
0.000036
ellagic acid

Gallus gallus
-
IP3K-A, maximal inhibition 75%
0.00022
ellagic acid
Homo sapiens
-
0.00055
ellagic acid
Homo sapiens
-
0.00069
ellagic acid
Rattus norvegicus
IP3K-C, maximal inhibition 85%
0.000094
epicatechin-3-gallate

Gallus gallus
-
IP3K-A, maximal inhibition 100%
0.000385
epicatechin-3-gallate
Rattus norvegicus
IP3K-C, maximal inhibition 100%
0.0004
epicatechin-3-gallate
Homo sapiens
-
0.00056
epicatechin-3-gallate
Homo sapiens
-
0.00012
epigallocatechin-3-gallate

Gallus gallus
-
IP3K-A, maximal inhibition 100%
0.00015
epigallocatechin-3-gallate
Homo sapiens
-
0.00021
epigallocatechin-3-gallate
Rattus norvegicus
IP3K-C, maximal inhibition 100%
0.00278
epigallocatechin-3-gallate
Homo sapiens
-
0.000058
gossypol

Gallus gallus
-
IP3K-A, maximal inhibition 100%
0.000115
gossypol
Homo sapiens
-
0.000175
gossypol
Rattus norvegicus
IP3K-C, maximal inhibition 100%
0.00034
gossypol
Homo sapiens
-
0.00017
hypericin

Gallus gallus
-
IP3K-A, maximal inhibition 100%
0.00017
hypericin
Rattus norvegicus
IP3K-C, maximal inhibition 100%
0.00018
hypericin
Homo sapiens
-
0.00021
hypericin
Homo sapiens
-
0.00015
myricetin

Homo sapiens
-
0.00029
myricetin
Rattus norvegicus
IP3K-C, maximal inhibition 62%
0.00054
myricetin
Gallus gallus
-
IP3K-A, maximal inhibition 85%
0.0042
myricetin
Homo sapiens
-
0.00018
quercetin

Gallus gallus
-
IP3K-A, maximal inhibition 80%
0.0003
quercetin
Homo sapiens
-
0.00039
quercetin
Rattus norvegicus
IP3K-C, maximal inhibition 71%
0.00125
quercetin
Homo sapiens
-
0.00017
Rose bengal

Rattus norvegicus
IP3K-C, maximal inhibition 100%
0.00052
Rose bengal
Homo sapiens
-
0.00219
Rose bengal
Homo sapiens
-
0.00312
Rose bengal
Gallus gallus
-
IP3K-A, maximal inhibition 100%
additional information
chlorogenic acid

Homo sapiens
IC > 0.1
additional information
chlorogenic acid
Homo sapiens
IC > 0.1
additional information
chlorogenic acid
Gallus gallus
-
IP3K-A, IC > 0.1
additional information
chlorogenic acid
Rattus norvegicus
IP3K-C, IC > 0.1
additional information
F-actin
Homo sapiens
the full length form of inositol 1,4,5-trisphosphate-3-kinase-A bundles F-actin in a concentration dependent manner, inhibition of the initial rate of gelsolin induces F-actin severing and the degree of bundling are half maximal at an similar concentration of about 300 nM, whereas inhibition of the rate of actin depolymerization after dilution to 100 nM actin is half maximal at about 30 nM, the much lower EC 50 for the latter effect may reflect the high affinity of enzyme for binding to F actin
-
additional information
F-actin
Homo sapiens
-
the full length form of inositol 1,4,5-trisphosphate-3-kinase-A bundles F-actin in a concentration dependent manner, inhibition of the initial rate of gelsolin induces F-actin severing and the degree of bundling are half maximal at an similar concentration of about 300 nM, whereas inhibition of the rate of actin depolymerization after dilution to 100 nM actin is half maximal at about 30 nM, the much lower EC 50 for the latter effect may reflect the high affinity of enzyme for binding to F actin
-
additional information
additional information
Rattus norvegicus
RnIP3K-C including the calmodulin binding and the catalytic domain shows a 3-fold lower IC50 value for 3',4',7,8-tetrahydroxyflavone than RnIP3K including only the calmodulin binding domain. The maximum degree of inhibition is unchanged. Together with the finding that Ca2+-calmodulin partly reverses IP3K inhibition indicates a facilitating but not essential involvement of the calmodulin binding domain in inhibitor binding.
-
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