Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide | i.e. W-7, calmodulin-antagonist | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
soluble | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | only together with calmodulin, completely reversible | Rattus norvegicus | |
Ca2+ | activation by Ca2+/calmodulin | Rattus norvegicus | |
Ca2+ | not activated by free Ca2+ | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus | inositol 1,4,5-trisphosphate is a second messenger | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus | inositol 1,4,5-trisphosphate mobilizes Ca2+ from the intracellular stores of permeabilized cells, enzyme is Ca2+-regulated | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
20fold | Rattus norvegicus |
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RINm5F cell | insulin-secreting | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00072 | - |
in absence of calmodulin | Rattus norvegicus |
Storage Stability | Organism |
---|---|
4°C, 48 h, 10-20% loss of activity | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Rattus norvegicus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | inositol 1,4,5-trisphosphate is a second messenger | Rattus norvegicus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | inositol 1,4,5-trisphosphate mobilizes Ca2+ from the intracellular stores of permeabilized cells, enzyme is Ca2+-regulated | Rattus norvegicus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus | |
Calmodulin | activation by Ca2+/calmodulin | Rattus norvegicus | |
Calmodulin | maximally 5fold stimulation by 0.01 mM Ca2+/calmodulin, reversible | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.12 | - |
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide | - |
Rattus norvegicus |