Application | Comment | Organism |
---|---|---|
medicine | enzyme converts tryptophan-containing cyclic dipeptides to their C2-regularly prenylated derivatives. In human leukemia K562 and ovarian cancer A2780 sens and A2780 CisR cell lines, prenylation at C2 leads to a significant increase of the cytotoxicity of the tested cyclic dipeptides in all the 14 cases | Aspergillus fumigatus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus fumigatus | Q4WAW7 | - |
- |
Aspergillus fumigatus Af293 | Q4WAW7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dimethylallyl diphosphate + cyclo-(D-Trp-D-Ala) | product yield 8.3% | Aspergillus fumigatus | diphosphate + cyclo-(D-2-dimethylallyl-Trp-D-Ala) | - |
? | |
dimethylallyl diphosphate + cyclo-(D-Trp-D-Ala) | product yield 8.3% | Aspergillus fumigatus Af293 | diphosphate + cyclo-(D-2-dimethylallyl-Trp-D-Ala) | - |
? | |
dimethylallyl diphosphate + cyclo-(D-Trp-D-Pro) | product yield 27.4% | Aspergillus fumigatus | diphosphate + cyclo-(2-dimethylallyl-D-Trp-D-Pro) | - |
? | |
dimethylallyl diphosphate + cyclo-(D-Trp-D-Pro) | product yield 27.4% | Aspergillus fumigatus Af293 | diphosphate + cyclo-(2-dimethylallyl-D-Trp-D-Pro) | - |
? | |
dimethylallyl diphosphate + cyclo-(D-Trp-L-Ala) | product yield 46.4% | Aspergillus fumigatus | diphosphate + cyclo-(D-2-dimethylallyl-Trp-L-Ala) | - |
? | |
dimethylallyl diphosphate + cyclo-(D-Trp-L-Ala) | product yield 46.4% | Aspergillus fumigatus Af293 | diphosphate + cyclo-(D-2-dimethylallyl-Trp-L-Ala) | - |
? | |
dimethylallyl diphosphate + cyclo-(D-Trp-L-Pro) | product yield 43.4% | Aspergillus fumigatus | diphosphate + cyclo-(2-dimethylallyl-D-Trp-L-Pro) | - |
? | |
dimethylallyl diphosphate + cyclo-(D-Trp-L-Pro) | product yield 43.4% | Aspergillus fumigatus Af293 | diphosphate + cyclo-(2-dimethylallyl-D-Trp-L-Pro) | - |
? | |
dimethylallyl diphosphate + cyclo-(D-Trp-L-Pro) | product yield 82.3% | Aspergillus fumigatus | diphosphate + cyclo-(D-2-dimethylallyl-Trp-L-Pro) | - |
? | |
dimethylallyl diphosphate + cyclo-(D-Trp-L-Pro) | product yield 82.3% | Aspergillus fumigatus Af293 | diphosphate + cyclo-(D-2-dimethylallyl-Trp-L-Pro) | - |
? | |
dimethylallyl diphosphate + cyclo-(L-Trp-D-Ala) | product yield 43.9% | Aspergillus fumigatus | diphosphate + cyclo-(L-2-dimethylallyl-Trp-D-Ala) | - |
? | |
dimethylallyl diphosphate + cyclo-(L-Trp-D-Pro) | product yield 75.7% | Aspergillus fumigatus | diphosphate + cyclo-(L-2-dimethylallyl-Trp-D-Pro) | - |
? | |
dimethylallyl diphosphate + cyclo-(L-Trp-Gly) | product yield 57.0% | Aspergillus fumigatus | diphosphate + cyclo-(L-2-dimethylallyl-Trp-Gly) | - |
? | |
dimethylallyl diphosphate + cyclo-(L-Trp-L-Ala) | product yield 53.5% | Aspergillus fumigatus | diphosphate + cyclo-(L-2-dimethylallyl-Trp-L-Ala) | - |
? | |
dimethylallyl diphosphate + cyclo-(L-Trp-L-His) | product yield 68.1% | Aspergillus fumigatus | diphosphate + cyclo-(L-2-dimethylallyl-Trp-L-His) | - |
? | |
dimethylallyl diphosphate + cyclo-(L-Trp-L-Leu) | product yield 70.9% | Aspergillus fumigatus | diphosphate + cyclo-(D-2-dimethylallyl-Trp-L-Leu) | - |
? | |
dimethylallyl diphosphate + cyclo-(L-Trp-L-Phe) | product yield 39.3% | Aspergillus fumigatus | diphosphate + cyclo-(L-2-dimethylallyl-Trp-L-Phe) | - |
? | |
dimethylallyl diphosphate + cyclo-(L-Trp-L-Trp) | product yield 67.0% | Aspergillus fumigatus | diphosphate + cyclo-(L-2-dimethylallyl-Trp-L-Trp) | - |
? | |
dimethylallyl diphosphate + cyclo-(L-Trp-L-Tyr) | product yield 72.4% | Aspergillus fumigatus | diphosphate + cyclo-(L-2-dimethylallyl-Trp-L-Tyr) | - |
? |