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Literature summary for 2.4.1.122 extracted from

  • Brockhausen, I.; Möller, G.; Merz, G.; Adermann, K.; Paulsen, H.
    Control of mucin synthesis: the peptide portion of synthetic O-glycopeptide substrates influences the activity of O-glycan core 1 UDPgalactose:N-acetyl-alpha-galactosaminyl-R beta 3-galactosyltransferase (1990), Biochemistry, 29, 10206-10212.
    View publication on PubMed
Search for more literature for 2.4.1.122

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.55
-
 A-P-(N-acetyl-D-galactosaminyl)T-S-S-A
-
 Rattus norvegicus
1.7
-
 N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
membrane
-
 Sus scrofa 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactose + glycoprotein N-acetyl-D-galactosamine Rattus norvegicus involved in O-glycan biosynthesis UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine Sus scrofa involved in O-glycan biosynthesis UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
colonic mucosa
-
 Rattus norvegicus
-
colonic mucosa
-
 Sus scrofa
-
liver
-
 Rattus norvegicus
-
stomach
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00088
-
 microsomal membranes, substrate: N-acetyl-D-galactosaminyl-alpha-benzyl Sus scrofa
0.00134
-
 microsomal membranes, substrate: A-P-N-acetyl-D-galactosaminyl-T-S-S-S Sus scrofa
0.0071
-
 partially purified enzyme, substrate: N-acetyl-D-galactosaminyl-alpha-benzyl Rattus norvegicus
0.031
-
 partially purified enzyme, substrate: A-P-N-acetyl-D-galactosaminyl-T-S-S-A Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactose + A-P-(N-acetyl-D-galactosaminyl)T-S-S-A synthetic peptide Rattus norvegicus UDP + A-P-(beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl)T-S-S-A
-
 ?
UDP-galactose + A-P-(N-acetyl-D-galactosaminyl)T-S-S-S synthetic peptide Sus scrofa UDP + A-P-(beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl)T-S-S-S
-
 ?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine glycosyl acceptor specificity study Rattus norvegicus UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine glycosyl acceptor specificity study Sus scrofa UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine involved in O-glycan biosynthesis Rattus norvegicus UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine involved in O-glycan biosynthesis Sus scrofa UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Rattus norvegicus UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 ?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Sus scrofa UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 ?

Synonyms

Synonyms Comment Organism
core 1 beta3-Gal-transferase
-
 Rattus norvegicus
core 1 beta3-Gal-transferase
-
 Sus scrofa
O-glycan core 1 UDPgalactose:N-acetyl-alpha-galactosaminyl-R beta3-galactosyltransferase
-
 Rattus norvegicus
O-glycan core 1 UDPgalactose:N-acetyl-alpha-galactosaminyl-R beta3-galactosyltransferase
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus
37
-
 assay at Sus scrofa