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UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP-alpha-D-galactose + alpha-D-GalNAc-OMe
UDP + alpha-D-Gal-(1->3)-alpha-D-GalNAc-OMe
UDP-alpha-D-galactose + Galbeta1-3GalNAcalpha1-4-nitrophenol
?
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
UDP-galactose + A-P-(N-acetyl-D-galactosaminyl)T-S-S-A
UDP + A-P-(beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl)T-S-S-A
-
synthetic peptide
-
-
?
UDP-galactose + A-P-(N-acetyl-D-galactosaminyl)T-S-S-S
UDP + A-P-(beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl)T-S-S-S
-
synthetic peptide
-
-
?
UDP-galactose + Ac-GHA-(GalNAcalpha1-)TSLPVTG-NH2
UDP + Ac-GHA-(Galbeta1-3GalNAcalpha1-)TSLPVTG-NH2
pH 7.0, 0.2 mM, 750% activity in H292-cells, 550% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + Ac-SCSTGHA-(GalNAcalpha1-)TSG-NH2
UDP + Ac-SCSTGHA-(Galbeta-1-3GalNAcalpha1-)TSG-NH2
pH 7.0, 0.2 mM, 50% activity in H292-cells, 40% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + Ac-STGHA-(GalNAcalpha1-)TSLPG-NH2
UDP + Ac-STGHA-(Galbeta1-3GalNAcalpha1-)TSLPG-NH2
pH 7.0, 0.2 mM, 425% activity in H292-cells, 275% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + Ac-SVS-(GalNAcalpha1-)TGHATSG-NH2
UDP + Ac-SVS-(Galbeta1-3GalNAcalpha1-)TGHATSG-NH2
pH 7.0, 0.2 mM, 300% activity in H292-cells, 450% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + Ac-TSSVS-(GalNAcalpha1-)TGHAG-NH2
UDP + Ac-TSSVS-(Galbeta1-3GalNAcalpha1-)TGHAG-NH2
pH 7.0, 0.2 mM, 400% activity in H292-cells, 4000% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + asialo bovine submaxillary mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo bovine submaxillary mucin
-
-
-
?
UDP-galactose + asialo ovine submaxillary mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo ovine submaxillary mucin
UDP-galactose + asialo-agalacto-alpha1-acid glycoprotein
UDP + galactosyl-beta-1,3-asialo-agalacto-alpha1-acid glycoprotein
-
-
-
-
?
UDP-galactose + asialo-agalacto-glycophorin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo-agalacto-glycophorin
-
-
-
?
UDP-galactose + asialo-mucin of Cowper's gland
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo-mucin of Cowper's gland
-
-
-
?
UDP-galactose + benzyl 2-(acetylamino)-2-deoxy-alpha-D-galactopyranoside
UDP + benzyl 2-(acetylamino)-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside
pH 7.0, 2 mM, 100% activity in H292-cells, 100% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + GalNAcalpha-Ser-Cy5
UDP + ?
-
-
-
-
?
UDP-galactose + GalNAcalpha1-O-phenyl
?
the enzyme is capable of utilizing UDP-Gal as the donor for the transfer of Gal residues to GalNAcalpha-1-O-phenyl and GalNAcalpha1-Ser/Thr for synthesizing core 1 structure Galbeta1-3GalNAcalpha1-R
-
-
?
UDP-galactose + ganglioside Gg3
UDP + galactosyl-beta-1,3-ganglioside Gg3
i.e. GalNAcbeta1,4-Galbeta1,4-Glcbeta1-ceramide
-
?
UDP-galactose + ganglioside GM2
UDP + galactosyl-beta-1,3-ganglioside GM2
UDP-galactose + glycophorin
?
-
-
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
UDP-galactose + immunglobulin A1
?
-
-
-
-
?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
UDP-galactose + N-acetyl-D-galactosamine
UDP + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine
UDP-galactose + N-acetyl-D-glucosamine
UDP + beta-D-galactosyl-1,3-N-acetyl-D-glucosamine
-
-
-
-
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
UDP-galactose + N-acetylgalactosaminitol
UDP + beta-D-galactosyl-(1,3)-N-acetylgalactosaminitol
-
-
-
?
UDP-galactose + p-nitrophenyl-beta-N-acetylgalactosamide
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-p-nitrophenyl
UDP-galactose + salivary gland mucin 81 N-acetyl-D-galactosamine
UDP + salivary gland mucin 81 D-galactosyl-1,3-N-acetyl-D-galactosamine
UDP-galactose + TTTV-(GalNAcalpha1-)TPTPTG
UDP + TTTV-(Galbeta1-3GalNAcalpha1-)TPTPTG
pH 7.0, 0.2 mM, 50% activity in H292-cells, 90% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + TTTVTP-(GalNAcalpha1-)TPTG
UDP + TTTVTP-(Galbeta1-3GalNAcalpha1-)TPTG
pH 7.0, 0.2 mM, 110% activity in H292-cells, 60% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + TTTVTPTP-(GalNAcalpha1-)TG
UDP + TTTVTPTP-(Galbeta1-3GalNAcalpha1-)TG
pH 7.0, 0.2 mM, 65% activity in H292-cells, 60% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
additional information
?
-
UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
biosynthesis of the O-polysaccharide is initiated with sequential assembly of repeating units on the cytoplasmic face of the inner membrane by glycosyltransferases WbnH, WbnJ, WbnK and WbnI. The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of Escherichia coli serotype O86
-
-
?
UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
biosynthesis of the O-polysaccharide is initiated with sequential assembly of repeating units on the cytoplasmic face of the inner membrane by glycosyltransferases WbnH, WbnJ, WbnK and WbnI. The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of Escherichia coli serotype O86
-
-
?
UDP-alpha-D-galactose + alpha-D-GalNAc-OMe
UDP + alpha-D-Gal-(1->3)-alpha-D-GalNAc-OMe
-
-
-
?
UDP-alpha-D-galactose + alpha-D-GalNAc-OMe
UDP + alpha-D-Gal-(1->3)-alpha-D-GalNAc-OMe
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
-
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
-
-
?
UDP-galactose + asialo ovine submaxillary mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo ovine submaxillary mucin
-
best substrate
-
?
UDP-galactose + asialo ovine submaxillary mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo ovine submaxillary mucin
-
-
-
?
UDP-galactose + ganglioside GM2
UDP + galactosyl-beta-1,3-ganglioside GM2
-
-
-
-
?
UDP-galactose + ganglioside GM2
UDP + galactosyl-beta-1,3-ganglioside GM2
i.e. GalNAcbeta1,4-(NeuAcalpha-2,3-)Galbeta1,4-Glcbeta1-ceramide
i.e. ganglioside GM1
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
-
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
-
-
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
i.e. core 1 structure
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
threonine alpha-D-galactosamine is preferred to serine alpha-D-galactosamine
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
high specificity for N-acetylgalactosaminyl residues linked to serine or threonine
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
enzyme is important in O-glycan biosynthesis in digestive organs
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
linked to serine or threonine of the peptide/protein
i.e. core 1 structure
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
threonine alpha-D-galactosamine is preferred to serine alpha-D-galactosamine
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Galbeta1,3-GalNAcalpha residues adjacent to Thr(GalNAc) reduces the activity
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
substrates with negatively charged amino acids on the N-terminal side are highly efficient substrates
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
glycosyl acceptor specificity study
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
glycosyl acceptor specificity study
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
glycosyl acceptor specificity study
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
major control factor in the biosynthesis of O-glycans
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
key enzyme in biosynthesis of core 1 O-glycans
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
involved in O-glycan biosynthesis
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
-
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
high specificity for N-acetylgalactosaminyl residues linked to serine or threonine
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
most active acceptor: macromolecular mucin glycopeptides with free N-acetylgalactosyl residues linked to polypeptide chain
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
glycopeptides with less than 5 amino acids containing terminal N-acetylgalactosaminyl residues
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
glycosyl acceptor specificity study
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
glycosyl acceptor specificity study
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
involved in O-glycan biosynthesis
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
the enzyme can O-glycosylate the mucin-like domains of glycoproteins in a site-specific manner dependent on the sort of glycosylation/presence of glycan C-terminal from site of action, a position specific glycosylation pattern results, regulation, overview
-
-
?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
-
-
?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
removal or substitution of the 3-OH group or removal of the 4-OH group abolishes enzyme activity, removal or substitution of the 6-OH reduces activity slightly leading to competititve substrates
-
?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
-
-
?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
-
-
?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
-
-
-
?
UDP-galactose + N-acetyl-D-galactosamine
UDP + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine
-
-
-
?
UDP-galactose + N-acetyl-D-galactosamine
UDP + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine
-
-
-
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
-
-
-
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
-
-
-
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
-
-
-
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
-
-
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
participates in synthesis of the core portion of O-serine- and O-threonine-linked oligosaccharides in respiratory acidic mucins
-
-
?
UDP-galactose + p-nitrophenyl-beta-N-acetylgalactosamide
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-p-nitrophenyl
-
-
-
?
UDP-galactose + p-nitrophenyl-beta-N-acetylgalactosamide
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-p-nitrophenyl
-
-
-
-
?
UDP-galactose + salivary gland mucin 81 N-acetyl-D-galactosamine
UDP + salivary gland mucin 81 D-galactosyl-1,3-N-acetyl-D-galactosamine
-
-
-
-
?
UDP-galactose + salivary gland mucin 81 N-acetyl-D-galactosamine
UDP + salivary gland mucin 81 D-galactosyl-1,3-N-acetyl-D-galactosamine
-
glycosylation pattern of the mucin, overview
-
-
?
additional information
?
-
-
the presence of multiple core-1 beta3GalT genes in Drosophila melanogaster suggests an increased complexity of core-1 O-glycan expression, which is possibly related to multiple developmental and physiological functions attributable to this class of glycans
-
-
?
additional information
?
-
enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage
-
-
?
additional information
?
-
enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage
-
-
?
additional information
?
-
enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage
-
-
?
additional information
?
-
analysis of glycan structure by mass spectrometry
-
-
-
additional information
?
-
-
poor substrates are low-molecular weight acceptors, e.g. N-acetylgalactosamine
-
-
?
additional information
?
-
-
no acceptor substrates: ovalbumin, beta-N-acetyl-D-glucosaminyl-benzyl
-
-
?
additional information
?
-
no acceptor substrates: ovalbumin, beta-N-acetyl-D-glucosaminyl-benzyl
-
-
?
additional information
?
-
-
elevated preferences for Gly at the +1 position with moderately high preferences for Phe and Tyr in the +3 position relative to the acceptor Thr-O-GalNAc
-
-
?
additional information
?
-
-
core 1 synthase specific molecular chaperone is essential for the expression of functional enzyme
-
-
?
additional information
?
-
-
poor substrates are low-molecular weight acceptors, e.g. N-acetylgalactosamine
-
-
?
additional information
?
-
-
no acceptor substrates: type A and type 0 blood group glycoprotein, ovomucoid, ovalbumin, and fetuin devoid of sialic acid and galactose
-
-
?
additional information
?
-
-
terminal alpha-2,6-linked sialic acid residues inhibit the enzyme
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
UDP-galactose + glycophorin
?
-
-
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
participates in synthesis of the core portion of O-serine- and O-threonine-linked oligosaccharides in respiratory acidic mucins
-
-
?
UDP-galactose + salivary gland mucin 81 N-acetyl-D-galactosamine
UDP + salivary gland mucin 81 D-galactosyl-1,3-N-acetyl-D-galactosamine
-
glycosylation pattern of the mucin, overview
-
-
?
additional information
?
-
UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
biosynthesis of the O-polysaccharide is initiated with sequential assembly of repeating units on the cytoplasmic face of the inner membrane by glycosyltransferases WbnH, WbnJ, WbnK and WbnI. The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of Escherichia coli serotype O86
-
-
?
UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
biosynthesis of the O-polysaccharide is initiated with sequential assembly of repeating units on the cytoplasmic face of the inner membrane by glycosyltransferases WbnH, WbnJ, WbnK and WbnI. The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of Escherichia coli serotype O86
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UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
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UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
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UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
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UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
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UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
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UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
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UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
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UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
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UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
enzyme is important in O-glycan biosynthesis in digestive organs
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UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
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major control factor in the biosynthesis of O-glycans
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UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
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key enzyme in biosynthesis of core 1 O-glycans
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UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
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involved in O-glycan biosynthesis
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UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
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involved in O-glycan biosynthesis
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UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
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the enzyme can O-glycosylate the mucin-like domains of glycoproteins in a site-specific manner dependent on the sort of glycosylation/presence of glycan C-terminal from site of action, a position specific glycosylation pattern results, regulation, overview
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additional information
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the presence of multiple core-1 beta3GalT genes in Drosophila melanogaster suggests an increased complexity of core-1 O-glycan expression, which is possibly related to multiple developmental and physiological functions attributable to this class of glycans
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additional information
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enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage
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additional information
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enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage
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additional information
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enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage
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additional information
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elevated preferences for Gly at the +1 position with moderately high preferences for Phe and Tyr in the +3 position relative to the acceptor Thr-O-GalNAc
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additional information
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core 1 synthase specific molecular chaperone is essential for the expression of functional enzyme
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metabolism
dGlcAT-P (EC 2.4.1.135) genetically interactes with dC1GalT1, and glucuronylated T antigen, rather than unmodified T antigen, contributes to precise localization of NMJ boutons and normal formation of basement membranes on muscles 6/7
malfunction
C1GalTA null mutant is lethal, mutant animals exhibit a striking morphogenetic defect in which the ventral nerve cord is greatly elongated and the brain hemispheres are misshapen
malfunction
mutant embryos show the loss of T antigens on the CNS and on a subset of hemocytes, 2 mutant lines, EY13370 and KG02976, have a P-element insertion in the CG9520 gene region, although the P-elements are located in the first intron of the gene in both lines, KG02976 homozygotes develop normally whereas some EY13370 homozygotes die during development and escaper homozygous EY13370 adult flies have abnormal legs, the levels of the enzyme transcripts in mutant third instar larvae homozygous for KG02976 or EY13370 are reduced to 60% and 15% of that of wild-type third instar larvae, terminal galactose of T antigen is defective in mutant embryos
malfunction
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mutations in the chaperone Cosmc, which is encoded by the X-chromosome gene (Xq24) in humans, leads to loss of T-synthase activity and expression of the abnormal Tn (GalNAc1-Ser/Thr) and Sialyl Tn (NeuAc2-3GalNAc1-Ser/Thr) antigens, which are also known as tumor-associated carbohydrate antigens, Tn syndrome is a rare autoimmune disease in which subpopulations of blood cells in all lineages carry an incompletely glycosylated membrane
malfunction
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oocyte-specific deletion at the primary follicle stage of T-synthase leads to a sustained increase in fertility mutant females ovulated 30-50% more eggs and has a sustained increase in litter size compared to controls, ovarian weights and follicle numbers are greater in mutants, but follicular apoptosis is not decreased, the number of follicles entering the growing pool is unaltered, but 3-week mutants ovulate fewer eggs, suggesting that increased fertility results from prolonged follicle development, T-synthase mutant ovaries also contain numerous multiple-oocyte follicles that appeared to form by adjacent, predominantly preantral, follicles joining
malfunction
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abrogation of the enzyme promotes membrane protein internalization. Disruption of core 1 O-glycosyltransferase activity induces endocytosis and faster accumulation of cell surface proteins in cytoplasmic vesicles and induces clathrin-mediated endocytosis. Enzyme-deficient human corneal keratinocytes display plasma membrane invaginations on the apical surface
malfunction
C1GALT1 overexpression enhances HNSCC cell viability, migration, and invasion, which can be reversed by erlotinib. Silencing of C1GALT1 suppresses the malignant behavior both in vitro and in vivo. C1GALT1 knockdown decreases the EGFR signaling in SAS, OEC-M1, and FaDu cells. Decreased C1GALT1 causes accumulation of Tn antigens
malfunction
core 1 beta1,3-galactosyltransferase (C1GALT1) expression is upregulated in HNSCC tumors and is associated with adverse clinicopathologic features. Moreover, high C1GALT1 expression predicts poor disease-free and overall survivals. C1GALT1 overexpression enhances HNSCC cell viability, migration, and invasion, which can be reversed by erlotinib. Silencing of C1GALT1 suppresses the malignant behavior both in vitro and in vivo. Blocking O-glycan elongation on epidermal growth factor receptor (EGFR) by C1GALT1 knockdown decreases EGF-EGFR binding affinity and inhibits EGFR signaling, thereby suppressing malignant phenotypes. C1GALT1 knockout also decreases the EGFR signaling in SAS cells as shown in two independent clones. C1GALT1 overexpression in SAS cells increases EGF-induced phosphorylation of EGFR at Y1068. By contrast, C1GALT1 knockdown decreases the EGFR signaling in OEC-M1 and FaDu cells. Decreased C1GALT1 causes accumulation of Tn antigens, which is detected by vicia villosa agglutinin (VVA) lectin
malfunction
dC1GalT1 loss in larvae leads to various defects, including a decreased number of circulating hemocytes, hyperdifferentiation of hematopoietic stem cells in lymph glands, malformation of the central nervous system, mislocalization of neuromuscular junction (NMJ) boutons, and ultrastructural abnormalities in NMJs and muscle cells. Mutant larvae show lower expression of glucuronylated T antigen on the muscles and at NMJs. Mislocalization of neuromuscular junction (NMJ) boutons and a partial loss of the basement membrane components collagen IV (Col IV) and nidogen (Ndg) at the muscle 6/7 boundary are observed. Those two phenotypes are correlated and identical to previously described phenotypes in dC1GalT1 mutant larvae
malfunction
the double mutant (DM) mouse generates oocytes lacking complex N- and O-glycans due to oocyte-specific deletion of core 1 beta1,3-galactosyltransferase (C1galt1) and N-acetylglucosaminyltransferase I (Mgat1) and has modified cumulus expansion. Oocyte-specific ablation of C1galt1 and Mgat1 may affect bone morphogenetic protein 15 synthesis or bioactivity, thereby reducing SMAD1/5/8 phosphorylation and hyaluronan production. The genotype of the DM mouse is oocyte-specific. Cumulus-oocyte complexes (COCs) from mice with oocyte-specific deletions of C1galt1 and Mgat1 have abnormal cumulus matrix that is resistant to hyaluronidase treatment
physiological function
C1GalTA is required for nervous system morphogenesis, C1GalTA is required for laminin O-glycosylation
physiological function
enzyme is responsible for the synthesis and function of T antigen (mucin-type O-glycan) in vivo
physiological function
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mucin-type protein O-glycosylation
physiological function
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T-synthase generates core 1-derived O-glycans
physiological function
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T-synthase is the key beta3-galactosyltransferase essential for biosynthesis of core 1 O-glycans (Gal beta1-3GalNAc alpha1-Ser/Thr) in animal cell glycoproteins
physiological function
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core 1 O-glycosylation is required to maintain transcellular barrier function. Core 1 O-glycans contribute to maintenance of apical barrier function on exposed mucosal surfaces by preventing clathrin-mediated endocytosis
physiological function
core 1 beta1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation and is overexpressed in various human malignancies with a role in head and neck squamous cell carcinoma (HNSCC). Enzyme C1GALT1 seems to promote in vitro disease progression in ovarian cancer. C1GALT1 modifies O-glycans on epidermal growth factor receptor (EGFR). C1GALT1 regulates phosphorylation, EGF-binding affinity, and O-glycosylation of EGFR to enhance malignant phenotypes in HNSCC cells. C1GALT1 regulates EGF-binding affinity of EGFR in HNSCC cells. C1GALT1 transfers galactose to Tn antigen to form T antigen. C1GALT1 is overexpressed in head and neck squamous cell carcinoma (HNSCC) tumors and high C1GALT1 expression predicts poor prognosis
physiological function
core 1 beta1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation. C1GALT1 regulates phosphorylation, EGF-binding affinity, and O-glycosylation of EGFR to enhance malignant phenotypes in HNSCC cells. Itraconazole blocks C1GALT1-mediated malignant phenotypes and EGFR activity, overview. C1GALT1 transfers galactose to Tn antigen to form T antigen
physiological function
T-synthase is required for the generation of complex O-glycans. The O-glycosylation has been implicated in receptor signalling and cell-matrix interactions
physiological function
the major components of basement membrane are proteins modified by glycans. T antigen (Galbeta1-3GalNAcalpha1-Ser/Thr) is an evolutionary-conserved mucin-type core 1 glycan structure in animals synthesized by core 1 beta1,3-galactosyltrasferase 1 (C1GalT1). T antigen produced by Drosophila C1GalT1 (dC1GalT1) is expressed in various tissues. T antigen formation occurs mainly due to the activity of Drosophila C1GalT1 orthologue
additional information
C1GALT1 is overexpressed in various human malignancies
additional information
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C1GALT1 is overexpressed in various human malignancies
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18
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