Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-lysine | stimulates activity on histone H4 | Saccharomyces cerevisiae |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli B834 DE3 cells | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H2O + 2-oxoglutarate | - |
Saccharomyces cerevisiae | 2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? | |
additional information | the enzyme has no activity with core histone substrates or calf thymus histones. However, when histone H4 purified from yeast is used as substrate, histone acetyltransferases activity is observed | Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HCS | - |
Saccharomyces cerevisiae |
LYS20 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | deletion of the homocitrate synthase gene suppresses htz1D DNA damage sensitivity | Saccharomyces cerevisiae |
physiological function | the enzyme is linked to the key process of DNA damage repair through the essential MYST family histone acetyltransferase Esa1 and the H2A.Z. The enzyme has a role in addition to amino acid synthesis, and functions in nuclear activities involving chromatin regulation that are distinct from its previously established role in lysine biosynthesis | Saccharomyces cerevisiae |