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Information on EC 2.3.3.14 - homocitrate synthase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.14 homocitrate synthase
IUBMB Comments
Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36, homoaconitate hydratase. The enzyme also acts with oxaloacetate as substrate, but more slowly [2,3].
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Word Map
  • 2.3.3.14
  • deficit
  • hair
  • sclerosis
  • gyrus
  • frontal
  • cingulate
  • resting-state
  • schizophrenia
  • prefrontal
  • emotional
  • auditory
  • bipolar
  • neuropsychological
  • high-content
  • anxiety
  • cochlea
  • insula
  • neuroimaging
  • verbal
  • occipital
  • voxel-based
  • tensor
  • holocarboxylase
  • hemichannels
  • precuneus
  • whole-brain
  • corti
  • relapsing-remitting
  • obsessive-compulsive
  • nervosa
  • ototoxic
  • salience
  • carboxylases
  • orbitofrontal
  • event-related
  • unmedicated
  • dlpfc
  • first-episode
  • tractography
  • parahippocampal
  • fasciculus
  • biotin-dependent
  • visuospatial
  • precentral
  • happy
  • psycinfo
  • impulsivity
  • stroop
  • gambling
  • bulimia
  • biotechnology
  • synthesis
  • medicine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
hcs, lys22, nifv2, tthcs, sphcs, lys21p, homocitrate synthetase, lys22p, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
show the reaction diagram
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