BRENDA - Enzyme Database show
show all sequences of 2.1.1.164

Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues

Singh, S.; Zhang, J.; Huber, T.D.; Sunkara, M.; Hurley, K.; Goff, R.D.; Wang, G.; Zhang, W.; Liu, C.; Rohr, J.; Van Lanen, S.G.; Morris, A.J.; Thorson, J.S.; Angew. Chem. Int. Ed. Engl. 53, 3965-3969 (2014)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4'-demethylrebeccamycin + S-adenosyl-L-methionine
Lechevalieria aerocolonigenes
-
rebeccamycin + S-adenosyl-L-homocysteine
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Lechevalieria aerocolonigenes
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4'-demethylrebeccamycin + S-adenosyl-L-methionine
-
733090
Lechevalieria aerocolonigenes
rebeccamycin + S-adenosyl-L-homocysteine
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4'-demethylrebeccamycin + S-adenosyl-L-methionine
Lechevalieria aerocolonigenes
-
rebeccamycin + S-adenosyl-L-homocysteine
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4'-demethylrebeccamycin + S-adenosyl-L-methionine
-
733090
Lechevalieria aerocolonigenes
rebeccamycin + S-adenosyl-L-homocysteine
-
-
-
?
General Information
General Information
Commentary
Organism
metabolism
the enzyme is involved in rebeccamycin biosynthesis
Lechevalieria aerocolonigenes
General Information (protein specific)
General Information
Commentary
Organism
metabolism
the enzyme is involved in rebeccamycin biosynthesis
Lechevalieria aerocolonigenes
Other publictions for EC 2.1.1.164
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733090
Singh
Facile chemoenzymatic strategi ...
Lechevalieria aerocolonigenes
Angew. Chem. Int. Ed. Engl.
53
3965-3969
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
698786
Singh
Structure and mechanism of the ...
Lechevalieria aerocolonigenes
J. Biol. Chem.
283
22628-22636
2008
-
-
-
1
10
-
-
19
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
1
10
-
-
-
-
19
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
10
-
-
-
-
-
-
-
-
10
10
697324
Zhang
RebG- and RebM-catalyzed indol ...
Lechevalieria aerocolonigenes
Chembiochem
7
795-804
2006
-
-
-
-
-
-
9
2
-
1
2
1
-
1
-
-
-
-
-
-
-
-
11
1
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
2
-
1
2
1
-
-
-
-
-
-
-
-
11
1
-
-
-
2
1
-
-
-
1
-
-
1
-
-
698453
Zhang
Natural product diversificatio ...
Lechevalieria aerocolonigenes
J. Am. Chem. Soc.
128
2760-2761
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
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-
-
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-
-
-
-
-
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-
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-
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-
1
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3
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