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Information on EC 2.1.1.164 - demethylrebeccamycin-D-glucose O-methyltransferase

for references in articles please use BRENDA:EC2.1.1.164
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IUBMB Comments
Catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is able to use a wide variety substrates, tolerating variation on the imide heterocycle, deoxygenation of the sugar moiety, and even indolocarbazole glycoside anomers . The enzyme is a member of the general acid/base-dependent O-methyltransferase family .
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The expected taxonomic range for this enzyme is: Lechevalieria aerocolonigenes
Synonyms
rebeccamycin MT, rebeccamycin O-methyltransferase, RebM, RebM., more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4'-demethylrebeccamycin + S-adenosyl-L-methionine = rebeccamycin + S-adenosyl-L-homocysteine
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