Crystallization (Comment) | Organism |
---|---|
structure in the free state at 2.3 A resolution. VAT-1 forms a dimer with the conserved NADPH-binding cleft on each protomer. The structure of VAT-1 in the NADP-bound state at 2.6 A resolution shows that NADP binds the binding cleft to create a putative active site with the nicotine ring | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0299 | - |
9,10-phenanthrenequinone | pH 7.8, 25°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | A0A024R1Z6 | - |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.64 | - |
substrate 9,10-phenanthrenequinone, pH 7.8, 25°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-naphthoquinone + NADPH + H+ | - |
Homo sapiens | 1,2-naphthoquinol + NADP+ | - |
? | |
9,10-phenanthrenequinone + NADPH + H+ | - |
Homo sapiens | 9,10-phenanthrenequinol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
VAT-1 | - |
Homo sapiens |
vesicle amine transport protein-1 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.13 | - |
9,10-phenanthrenequinone | pH 7.8, 25°C | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
37.8 | - |
9,10-phenanthrenequinone | pH 7.8, 25°C | Homo sapiens |