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Information on EC 1.6.5.5 - NADPH:quinone reductase

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IUBMB Comments
A zinc enzyme, specific for NADPH. Catalyses the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates . Dicoumarol [cf. EC 1.6.5.2 NAD(P)H dehydrogenase (quinone)] and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O2 . In some mammals, the enzyme is abundant in the lens of the eye, where it is identified with the protein zeta-crystallin.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
zeta-crystallin, old yellow enzyme, nadph:quinone oxidoreductase, tcoye, nad(p)h:menadione oxidoreductase, nad(p)h:(quinone-acceptor) oxidoreductase, nad(p)h-quinone reductase, p1-zcr, zta1p, nitroreductase a, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
NADPH + H+ + 2 quinone = NADP+ + 2 semiquinone
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