Application | Comment | Organism |
---|---|---|
analysis | development of a functional affinity-based small-molecule probe composed of a potent small-molecule NQO1 inhibitor 4-hydroxy-3-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2H-1-benzopyran-2-one as the recognition group, a linker and the fluorophores group FITC. The probe exhibits good inhibitory activity of NQO1 and can be used to label the protein in A549 cells at the micromolar level | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxy-3-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2H-1-benzopyran-2-one | 10 microM, 89.2% inhibition. At 0.0084 microM, 50% toxicity in A549 cells in the presence of 20 mM beta-lapachone. Inhibitor is used to built a functional affinity-based small-molecule fluoresent probe composed of the NQO1 inhibitor as the recognition group, a linker and the fluorophores group FITC | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15559 | - |
- |