Literature summary for 1.5.5.3 extracted from

Buchalski, B.; Wood, K.D.; Challa, A.; Fargue, S.; Holmes, R.P.; Lowther, W.T.; Knight, J.
The effects of the inactivation of hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria (2020), Biochim. Biophys. Acta, 1866, 165633 .

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Application

Application	Comment	Organism
medicine	creation of a ProDH2 knock out mouse model. The lack of hydroxyproline dehydrogenase in primary hyperoxalurias mouse models results in lower levels of urinary oxalate excretion. In the double knockout mouse, lacking both glyoxylate reductase/hydroxypyruvate reductase Grhpr and ProDH2, calcium-oxalate crystal deposition in the kidney is prevented, when placed on a 1% hydroxyproline diet	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8VCZ9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
ProDH2	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	creation of a ProDH2 knock out mouse model. The lack of hydroxyproline dehydrogenase in primary hyperoxalurias mouse models results in lower levels of urinary oxalate excretion. In the double knockout mouse, lacking both glyoxylate reductase/hydroxypyruvate reductase Grhpr and ProDH2, calcium-oxalate crystal deposition in the kidney is prevented, when placed on a 1% hydroxyproline diet	Mus musculus

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Release 2023.1 (January 2023)