Application | Comment | Organism |
---|---|---|
pharmacology | diminished DAO activity and elevations in D-serine may serve as an effective therapeutic intervention for the treatment of psychiatric symptoms | Mus musculus |
Cloned (Comment) | Organism |
---|---|
genotyping | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
D481N | Grin1D481N mice show deficits in sociability, prolonged latent inhibition, enhanced startle reactivity and impaired spatial memory | Mus musculus |
G181R | the hypofunctional Dao1G181R mutation elevates brain levels of D-serine, but alone it does not affect performance in the behavioral measures | Mus musculus |
G181R/D481N | compared to animals with only the Grin1D481N mutation, mice with both the Dao1G181R and Grin1D481N mutations display an improvement in social approach and spatial memory retention, as well as a reversal of abnormally persistent latent inhibition and a partial normalization of startle responses | Mus musculus |
additional information | long-term increases in the brain levels of the endogenous N-methyl-D-aspartate receptor, NMDAR, glycine site agonist D-serine, through the genetic inactivation of its catabolic enzyme D-amino acid oxidase in mice | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-serine + H2O + O2 | Mus musculus | - |
2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P18894 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-serine + H2O + O2 | - |
Mus musculus | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DAO | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | increased level of D-serine resulting from decreased catalysis correct the performance of mice with deficient NMDAR glycine site activation in behavioral tasks relevant to the negative and cognitive symptoms of schizophrenia | Mus musculus |