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Literature summary for 1.4.3.13 extracted from

  • Bhuvanasundar, R.; Ragavachetty, N.; Singh, N.; Coral, K.; Deepa, P.; Sulochana, K.
    Expression, purification and characterization of a biologically active and thermally stable human lysyl oxidase (2019), Indian J. Biochem. Biophys., 56, 105-116 .
No PubMed abstract available
Search for more literature for 1.4.3.13

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
beta-aminopropionitrile 0.4 mM, 20% inhibition Homo sapiens
homocysteine 0.03 mM, up to 50% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.373
-
 1,5-Diaminopentane pH 8.2, temperature not specified in the publication Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[collagen]-L-lysine + O2 + H2O Homo sapiens
-
 [collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P28300
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,5-diaminopentane + O2 + H2O
-
 Homo sapiens ? + NH3 + H2O2
-
 ?
[collagen]-L-lysine + O2 + H2O
-
 Homo sapiens [collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
LOX
-
 Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
90
-
 the enzyme maintains its secondary structure till 90°C Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
7290
-
 1,5-Diaminopentane pH 8.2, temperature not specified in the publication Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7.5 8.5 pH 7.5: about 55% of maximal activity, pH 8.5: about 85% of maximal activity Homo sapiens

General Information

General Information Comment Organism
drug target the enzyme is a promising therapeutic target for the progression of cancer and fibrosis Homo sapiens