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1,5-diaminopentane + O2 + H2O
?
-
-
-
-
?
1,5-diaminopentane + O2 + H2O
? + NH3 + H2O2
6,6-dideutrolysine + O2 + H2O
? + NH3 + H2O2
agmatine + O2 + H2O
?
-
-
-
?
benzylamine + O2 + H2O
benzaldehyde + NH3 + H2O2
-
-
-
-
?
collagen + H2O + O2
allysyl-collagen + NH3 + H2O2
collagen + O2 + H2O
?
-
collagen type I, II, III, IV, VI, VIII and X
-
-
?
collagen 2a1 + O2 + H2O
?
-
-
-
?
collagen III + O2 + H2O
allysyl-collagen III + NH3 + H2O2
-
-
-
-
?
dichlorodihydrofluorescein diacetate + O2 + H2O
? + NH3 + H2O2
-
-
-
-
?
elastin + H2O + O2
allysyl-elastin + NH3 + H2O2
elastin + O2 + H2O
?
-
-
-
-
?
histamine + O2 + H2O
?
-
-
-
?
histone H2 + O2 + H2O
?
-
recombinant mature LOX and C-terminally deleted enzyme
-
-
?
lysine + O2 + H2O
?
-
-
-
?
lysine:tyrosine (4:1) heteropolymer + O2 + H2O
? + NH3 + H2O2
n-alkylamine + O2 + H2O
aldehyde + NH3 + H2O2
peptide acK685 + O2 + H2O
? + NH3 + H2O2
-
-
-
-
?
peptidyl-L-hydroxylysyl-peptide + O2 + H2O
peptidyl-L-2-amino-5-hydroxy-6-oxohexanoyl-peptide + NH3 + H2O2
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
polylysine + O2 + H2O
allysine + H2O2 + NH3
-
-
-
-
?
putrescine + O2 + H2O
?
-
-
-
?
spermidine + O2 + H2O
?
-
-
-
?
spermine + O2 + H2O
?
-
-
-
?
tropoelastin + ?
?
-
LOXL1 catalyzes the polymerization of tropoelastin
-
-
?
tropoelastin + H2O + O2
?
-
-
-
?
tropoelastin + O2 + H2O
?
-
-
-
?
tropoelastin + O2 + H2O
? + H2O2 + NH3
-
oxidation of L-lysine residues, substrate from mammalia
-
-
?
[collagen]-L-lysine + O2 + H2O
[collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
[elastin]-L-lysine + O2 + H2O
[elastin]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix
-
-
?
additional information
?
-
1,5-diaminopentane + O2 + H2O
? + NH3 + H2O2
-
-
-
-
?
1,5-diaminopentane + O2 + H2O
? + NH3 + H2O2
-
-
-
?
6,6-dideutrolysine + O2 + H2O
? + NH3 + H2O2
-
-
-
-
?
6,6-dideutrolysine + O2 + H2O
? + NH3 + H2O2
-
-
-
-
?
cadaverine + O2 + H2O
?
-
-
-
-
?
cadaverine + O2 + H2O
?
-
-
-
?
collagen + H2O + O2
allysyl-collagen + NH3 + H2O2
-
-
-
?
collagen + H2O + O2
allysyl-collagen + NH3 + H2O2
-
the enzyme initiates the enzymatic stage of collagen and elastin cross-linking. Lysyl oxidase activity is essential for the integrity maintenance of the dermis and for the homeostasis of the epidermis. The LOX protein plays a role in the skin carcinomas and invasion but not through its enzymatic activity
-
-
?
elastin + H2O + O2
allysyl-elastin + NH3 + H2O2
-
-
-
?
elastin + H2O + O2
allysyl-elastin + NH3 + H2O2
-
-
-
-
?
elastin + H2O + O2
allysyl-elastin + NH3 + H2O2
-
the enzyme initiates the enzymatic stage of collagen and elastin cross-linking. Lysyl oxidase activity is essential for the integrity maintenance of the dermis and for the homeostasis of the epidermis. The LOX protein plays a role in the skin carcinomas and invasion but not through its enzymatic activity
-
-
?
histone H1 + O2 + H2O
?
-
L-lysine residues in histone H1
-
-
?
histone H1 + O2 + H2O
?
-
L-lysine residues in histone H1
-
-
?
histone H1 + O2 + H2O
?
-
recombinant mature LOX and C-terminally deleted enzyme
-
-
?
histone H1 + O2 + H2O
?
-
L-lysine residues in histone H1
-
-
?
lysine:tyrosine (4:1) heteropolymer + O2 + H2O
? + NH3 + H2O2
-
-
-
-
?
lysine:tyrosine (4:1) heteropolymer + O2 + H2O
? + NH3 + H2O2
-
-
-
-
?
n-alkylamine + O2 + H2O
aldehyde + NH3 + H2O2
-
synthetic substrates
-
-
?
n-alkylamine + O2 + H2O
aldehyde + NH3 + H2O2
-
synthetic substrates
-
-
?
n-alkylamine + O2 + H2O
aldehyde + NH3 + H2O2
-
synthetic substrates
-
-
?
peptidyl-L-hydroxylysyl-peptide + O2 + H2O
peptidyl-L-2-amino-5-hydroxy-6-oxohexanoyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-hydroxylysyl-peptide + O2 + H2O
peptidyl-L-2-amino-5-hydroxy-6-oxohexanoyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-hydroxylysyl-peptide + O2 + H2O
peptidyl-L-2-amino-5-hydroxy-6-oxohexanoyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-hydroxylysyl-peptide + O2 + H2O
peptidyl-L-2-amino-5-hydroxy-6-oxohexanoyl-peptide + NH3 + H2O2
-
part of tropocollagen and tropoelastin
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
deamination of lysyl and hydroxylysyl residues is part of the pyridinoline biosynthetic pathway, pyridinoline is involved in formation of intracellular and extracellular collagen cross-links responsible for aging of connective tissue
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
enzyme plays a critical role in the formation and repair of extracellular matrix, formation of cross-links in fibrillar collagen and elastin, only in fibrillar aggregates
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
in a variety of basic globular proteins
i.e. peptidyl-L-alpha-aminoadipic-delta-semialdehyde
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
enzyme plays a critical role in the formation and repair of extracellular matrix, formation of cross-links in fibrillar collagen and elastin, only in fibrillar aggregates
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
key enzyme in formation of lysine cross-links in side collagen and elastin molecules
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
substrates are proteins of the extracellular matrix
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
in a variatey of basic globular proteins
i.e. peptidyl-L-alpha-aminoadipic-delta-semialdehyde
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
in collagen and elastin fibrills
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
657782, 658189, 659197, 659751, 685940, 685949, 685981, 686366, 686392, 687919, 724520 -
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
formation of cross-links in mature fibrillar collagen and elastin fibers in the extracellular space
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
initiation of covalent intermolecular cross-linking of collagen by the enzyme action on telopeptidyl lysine and hydroxylysine residues
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
lysyl oxidase plays a critical role in the formation of the extracellular matrix, and its activity is required for the normal maturation and cross-linking of collagen and elastin
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
enzyme plays a critical role in the formation and repair of extracellular matrix, formation of cross-links in fibrillar collagen and elastin, only in fibrillar aggregates
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
in a variatey of basic globular proteins
i.e. peptidyl-L-alpha-aminoadipic-delta-semialdehyde
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
part of tropocollagen and tropoelastin
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
part of elastin and collagen
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
part of elastin and collagen
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
crosslinkage in fibrillar collagen and elastin
-
-
?
[collagen]-L-lysine + O2 + H2O
[collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
-
-
-
?
[collagen]-L-lysine + O2 + H2O
[collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix
-
-
?
additional information
?
-
-
enzyme modifies cellular activity and can function as a messenger shuttling information between the intra- and extracellular compartments
-
-
?
additional information
?
-
-
enzyme contains a cytokine receptor domain, substrate specificity, preference for the L-lysine residues in the sequence N-acetyl-(Gly)4-Glu-Lys-(Gly)5-amide, enzyme is tightly associated to the substrates in connective tissue
1.4.3.13 protein-lysine 6-oxidase
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