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Literature summary for 1.4.3.13 extracted from

  • Santhanam, A.N.; Baker, A.R.; Hegamyer, G.; Kirschmann, D.A.; Colburn, N.H.
    Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion (2010), Oncogene, 29, 3921-3932.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.13

Inhibitors

Inhibitors Comment Organism Structure
beta-aminopropionitrile a specific LOX inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P28300
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
LOX
-
 Homo sapiens
lysyl oxidase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens tumor suppressor Pdcd4 inhibits LOX expression, loss of Pdcd4 in human nonmetastatic breast cancer cells increases the expression of LOX mRNA down
Homo sapiens LOX is induced by hypoxia, loss of Pdcd4 in human nonmetastatic breast cancer cells increases the expression of LOX mRNA, and loss of Pdcd4 also augments hypoxia induction of LOX up

General Information

General Information Comment Organism
additional information LOX is a hypoxia-inducible amine oxidase, the activity of which enhances breast cancer cell invasion in vitro and in vivo. Specific inhibition of LOX activity by beta-aminopropionitrile or small interfering RNA decreased the invasiveness of T-47D and MCF-7 breast cancer cells attenuated for Pdcd4 function. Tumor suppressor Pdcd4 inhibits breast cancer cell migration and invasion in vitro. Loss of Pdcd4 in human nonmetastatic breast cancer cells increases the expression of lysyl oxidase mRNA Homo sapiens