Literature summary for 1.3.1.70 extracted from

Capell-Hattam, I.M.; Sharpe, L.J.; Qian, L.; Hart-Smith, G.; Prabhu, A.V.; Brown, A.J.
Twin enzymes, divergent control The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally (2020), J. Biol. Chem., 295, 2850-2865 .

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General Stability

General Stability	Organism
The enzyme is degraded by the proteasome and ubiquitinated. Enzyme turnover is triggered by a wide variety of sterols	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Homo sapiens	5783	-
nucleus	-	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+	Homo sapiens	-	4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O76062	-	-
Homo sapiens	Q14739	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BE(2)-C cell	-	Homo sapiens	-
blood	high expression	Homo sapiens	-
brain	high expression	Homo sapiens	-
colon	highest expression	Homo sapiens	-
HeLa cell	-	Homo sapiens	-
Huh-7 cell	-	Homo sapiens	-
liver	high expression	Homo sapiens	-
skin	highest expression in sun-exposed skin	Homo sapiens	-
spleen	high expression	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+	-	Homo sapiens	4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+	-	?
dihydro-follicular fluid meiosis-activating sterol + NADPH + H+	-	Homo sapiens	dihydro-testis meiosis-activating sterol + NADP+	-	?
follicular fluid meiosis-activating sterol + NADPH + H+	-	Homo sapiens	testis meiosis-activating sterol + NADP+	-	?

Subunits

Subunits	Comment	Organism
?	x * 50000, SDS-PAGE	Homo sapiens
?	x * 370000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
14-dehydrocholesterol reductase	-	Homo sapiens
C14-SR	-	Homo sapiens
C14-sterol reductase	-	Homo sapiens
DHCR14	-	Homo sapiens
lamin-B receptor	-	Homo sapiens
LBR	-	Homo sapiens
TM7SF2	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	when cholesterol levels are high, enzyme gene expression is inhibited	down
Homo sapiens	under conditions of low cholesterol, enzyme gene expression is up-regulated by SREBP-2	up

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Release 2023.1 (January 2023)