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Information on EC 1.3.1.70 - DELTA14-sterol reductase
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EC Tree
1.3.1.70 DELTA14-sterol reductaseIUBMB Comments
This enzyme acts on a range of steroids with a 14(15)-double bond.
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Word Map
- 1.3.1.70
- lamins
- envelope
- chromatin
- heterochromatin
- nucleoplasm
- ergosterol
- lanosterol
-
emerin
-
lamina-associated
-
greenberg
- laminopathies
-
14alpha-demethylase
- fenpropimorph
-
ff-mas
-
chromatin-binding
-
hypolobulated
- pharmacology
-
pelger-huet
- agriculture
- analysis
The enzyme appears in viruses and cellular organisms
Synonyms
lamin b receptor, tm7sf2, erg24, 14-reductase, sterol c-14 reductase, dhcr14, fackel, c14sr, delta14-reductase, fk-j3158, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
14-reductase
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-
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3beta-hydroxysterol DELTA14-reductase
C-14 reductase
C-14 sterol reductase
C14-SR
C14SR
DELTA14-reductase
DELTA14-SR
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DELTA14SR
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DELTA7,14-steroid 14-reductase
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DELTA7,14-sterol 14-reductase
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DELTA7,14-sterol DELTA14-reductase
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DELTA7,14-sterol-14-reductase
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DELTA8,14-hydroxy steroid DELTA14(15)-reductase
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DELTA8,14-steroid 14-reductase
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DELTA8,14-sterol 14-reductase
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DELTA8,14-sterol DELTA14-reductase
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DELTA8,14-sterol-14-reductase
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ERG24
erg24A
erg24B
FACKEL protein
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integral membrane sterol reductase
LBR
MaSR1
reductase, DELTA8,14-hydroxy steroid DELTA14(15)-
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sterol 14-reductase
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sterol C-14 reductase
sterol C14-reductase
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sterol DELTA14,15-reductase
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sterol DELTA14-reductase
TM7SF2
3beta-hydroxysterol DELTA14-reductase
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besides the endoplasmic reticulum 3beta-hydroxysterol DELTA14-reductase (C14SR) encoded by TM7SF2 gene, the lamin B receptor (LBR) of the inner nuclear membrane possesses 3beta-hydroxysterol DELTA14-reductase activity
C-14 reductase
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C-14 sterol reductase
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DELTA14-reductase
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sterol C-14 reductase
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sterol DELTA14-reductase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
mechanism
-
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
mechanism
-
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
mechanism
-
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
regulation, regulatory mechanism, enzyme induction and suppression, dietary induction
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4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
this enzyme acts on a range of steroids with a 14(15)-double bond
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4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
reduction of 14-double bond of conjugated DELTA8,14-sterols and DELTA7,14-sterols
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4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
determination of residues critical for activity, overview
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4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
residues G225, Y317, and E475 are not essential for activity
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4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
mechanism
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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DELTA14-reduction in steroids
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ DELTA14-oxidoreductase
This enzyme acts on a range of steroids with a 14(15)-double bond.
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CAS REGISTRY NUMBER
COMMENTARY
69403-07-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4,4-dimethyl-5alpha-cholesta-7,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-7-en-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,12,24-trien-3beta-ol + NADPH + H+
4,4-dimethylzymosterol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
4alpha-methylfecosterol + NADP+
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
5alpha-cholesta-7,14-dien-3beta-ol + NADPH
5alpha-cholesta-7-en-3beta-ol + NADP+
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43% activity compared with 4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol
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-
?
5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH
5alpha-ergosta-8,24(28)-dien-3beta-ol + NADP+
dihydro-follicular fluid meiosis-activating sterol + NADPH + H+
dihydro-testis meiosis-activating sterol + NADP+
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?
ergosta-8,14-dien-3beta-ol + NADPH
ergosta-8-en-3beta-ol + NADP+
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DELTA8,14-sterol, ignosterol
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?
follicular fluid meiosis-activating sterol + NADPH
testicular meiosis-activating sterol + NADP+
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?
follicular fluid meiosis-activating sterol + NADPH + H+
testis meiosis-activating sterol + NADP+
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?
4,4-dimethyl-5alpha-cholesta-7,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-7-en-3beta-ol + NADP+
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?
4,4-dimethyl-5alpha-cholesta-7,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-7-en-3beta-ol + NADP+
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64% activity compared with 4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol
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?
4,4-dimethyl-5alpha-cholesta-8,12,24-trien-3beta-ol + NADPH + H+
4,4-dimethylzymosterol + NADP+
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?
4,4-dimethyl-5alpha-cholesta-8,12,24-trien-3beta-ol + NADPH + H+
4,4-dimethylzymosterol + NADP+
Aspergillus fumigatus FGSC A1163
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
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C29DELTA8,14,24
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
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-
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
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-
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
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probably the natural substrate
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
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-
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
probably the natural substrate
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
-
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
-
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?
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
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-
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?
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
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-
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?
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
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best substrate, probably natural substrate
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?
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
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presumably the natural substrate
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?
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
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-
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?
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
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-
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?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
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-
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?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
-
-
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?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
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?
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
4alpha-methylfecosterol + NADP+
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?
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
4alpha-methylfecosterol + NADP+
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step in the biosynthesis of the brassicasterol phytohormones, catalyzed by enzyme FK
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?
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
4alpha-methylfecosterol + NADP+
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?
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
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4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
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?
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
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4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
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?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
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DELTA8,14-cholestadien-3beta-ol
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?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
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C27DELTA8,14
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?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
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DELTA8,14-cholestadien-3beta-ol
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?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
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?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
the substrate accumulates in patients suffering autosomal recessive HEM/Greenberg skeletal dysplasia
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?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
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DELTA8,14-cholestadien-3beta-ol
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?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
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53% activity compared with 4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol
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?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
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DELTA8,14-cholestadien-3beta-ol
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?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
5alpha-cholesta-8-en-3beta-ol + NADP+
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LBR
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?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
5alpha-cholesta-8-en-3beta-ol + NADP+
-
TM7SF2
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-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
5alpha-cholesta-8-en-3beta-ol + NADP+
-
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
5alpha-cholesta-8-en-3beta-ol + NADP+
-
-
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?
5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH
5alpha-ergosta-8,24(28)-dien-3beta-ol + NADP+
-
-
-
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?
5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH
5alpha-ergosta-8,24(28)-dien-3beta-ol + NADP+
-
-
-
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?
isofucosterol + NADPH
sitosterol + NADP+
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step in the biosynthesis of the brassicasterol phytohormones, catalyzed by bifunctinal enzyme DIM1/CBB1/DWF1
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?
additional information
?
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brassicasterols have regulatory function in the plants concerning growth and development, the enzyme is up-regulated by several growth-promoting hormones including brassinolide and auxin, overview
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?
additional information
?
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enzyme acts on a range of steroids with a 14(15)-double bond
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?
additional information
?
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14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
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?
additional information
?
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important essential enzyme of cholesterol biosynthesis from lanosterol
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?
additional information
?
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enzyme plays a key role in sterol biosynthesis, sterol content in vivo
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?
additional information
?
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enzyme acts on a range of steroids with a 14(15)-double bond
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?
additional information
?
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enzyme involved in sterol, phytosterol, biosynthesis, DELTA8,14-sterols are intermediates in the biosynthesis of higher plant sterols, phytosterols
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?
additional information
?
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enzyme acts on a range of steroids with a 14(15)-double bond
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?
additional information
?
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14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
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?
additional information
?
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important essential enzyme of cholesterol biosynthesis from lanosterol
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?
additional information
?
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enzyme plays a key role in sterol biosynthesis, sterol content in vivo
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?
additional information
?
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enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
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?
additional information
?
-
enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
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?
additional information
?
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enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
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?
additional information
?
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C14SR is encoded by the TM7SF2 gene. TM7SF2 but not LBR, gene expression is regulated by cell sterol levels in HepG2 (human) and H-35 (rat) hepatoma cells. Primary role of C14SR in human cholesterol biosynthesis
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-
?
additional information
?
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role of LBR in the cholesterol biosynthesis pathway is unclear
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?
additional information
?
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enzyme MaSR1 can reduce the double bond of a cholesterol biosynthetic intermediate analogously to the human enzyme
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?
additional information
?
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enzyme MaSR1 can reduce the double bond of a cholesterol biosynthetic intermediate analogously to the human enzyme
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?
additional information
?
-
enzyme MaSR1 can reduce the double bond of a cholesterol biosynthetic intermediate analogously to the human enzyme
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?
additional information
?
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enzyme MaSR1 can reduce the double bond of a cholesterol biosynthetic intermediate analogously to the human enzyme
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-
?
additional information
?
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enzyme plays a key role in sterol biosynthesis
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?
additional information
?
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enzyme plays a key role in sterol biosynthesis, sterol content in vivo
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?
additional information
?
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the charge and geometry given via residues E233, R235, D289, K351, R458, and R461 is important for enzyme activity
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?
additional information
?
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enzyme acts on a range of steroids with a 14(15)-double bond
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?
additional information
?
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enzyme acts on a range of steroids with a 14(15)-double bond
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?
additional information
?
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reduction of 14-double bond of conjugated DELTA8,14-diene sterols and DELTA7,14-diene sterols
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?
additional information
?
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anaerobic conditions yield maximal rates of reduction
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?
additional information
?
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4-nor-methyldiene sterols, 5alpha-cholesta-8,14-dien-3beta-ol, and 5alpha-cholesta-7,14-dien-3beta-ol are reduced at about 50% of the rate of the corresponding 4-gem-dimethyldiene sterols, for both the C27-sterol and C29-sterol, the higher reaction rate of the 8,14-diene system is consistently observed over the isomeric 7,14-diene
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-
?
additional information
?
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catalyzes anaerobically NADPH-dependent reduction of 14-double bond of 8,14-diene or 7,14-diene sterols that are sterol intermediates formed during C-32 demethylation in cholesterol biosynthesis from lanosterol in mammals
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-
?
additional information
?
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catalyzes anaerobically NADPH-dependent reduction of 14-double bond of 8,14-diene or 7,14-diene sterols that are sterol intermediates formed during C-32 demethylation in cholesterol biosynthesis from lanosterol in mammals
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-
?
additional information
?
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reduction of 14-double bond of sterol-conjugated dienes
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?
additional information
?
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14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
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-
?
additional information
?
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microsomal enzyme of cholesterol biosynthesis from lanosterol
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-
?
additional information
?
-
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important essential enzyme of cholesterol biosynthesis from lanosterol
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-
?
additional information
?
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enzyme acts on a range of steroids with a 14(15)-double bond
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?
additional information
?
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reduction of DELTA8,14-intermediate in ergosterol biosynthetic pathway to DELTA8-intermediate occurs by the trans addition of two hydrogens to the 14alpha- and 15beta-positions
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-
?
additional information
?
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enzyme of biosynthetic pathways of ergosterol, major sterol in yeast, and cholesterol including a DELTA8,14-sterol intermediate as result of demethylation of lanosterol at C-14
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?
additional information
?
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essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
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?
additional information
?
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essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
-
-
?
additional information
?
-
-
enzyme acts on a range of steroids with a 14(15)-double bond
-
-
?
additional information
?
-
-
reduction of DELTA8,14-intermediate in ergosterol biosynthetic pathway to DELTA8-intermediate occurs by the trans addition of two hydrogens to the 14alpha- and 15beta-positions
-
-
?
additional information
?
-
-
enzyme of biosynthetic pathways of ergosterol, major sterol in yeast, and cholesterol including a DELTA8,14-sterol intermediate as result of demethylation of lanosterol at C-14
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-
?
additional information
?
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essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
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-
?
additional information
?
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enzyme is involved in de novo synthesis of progesterone from lanosterol via cholesterol, pathway overview
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-
?
additional information
?
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enzyme acts on a range of steroids with a 14(15)-double bond
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?
additional information
?
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-
DELTA8,14 derivatives are the only substrates to be transformed under normal biosynthetic conditions
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?
additional information
?
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-
no activity with 5alpha-cholesta-7,14-dien-3beta-ol, 7,14-cholestadien-3beta-ol or 5alpha-cholest-14-en-3beta-ol, 14-cholesten-3beta-ol
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-
?
additional information
?
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-
important roles of 4alpha-methyl group and side-chain substitution for recognition but not for catalysis, presence of DELTA8(9) unsaturation is compulsory for catalysis
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
-
presumably the natural substrate
-
-
?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
4alpha-methylfecosterol + NADP+
-
step in the biosynthesis of the brassicasterol phytohormones, catalyzed by enzyme FK
-
-
?
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
the substrate accumulates in patients suffering autosomal recessive HEM/Greenberg skeletal dysplasia
-
-
?
follicular fluid meiosis-activating sterol + NADPH
testicular meiosis-activating sterol + NADP+
-
-
-
-
?
isofucosterol + NADPH
sitosterol + NADP+
-
step in the biosynthesis of the brassicasterol phytohormones, catalyzed by bifunctinal enzyme DIM1/CBB1/DWF1
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
probably the natural substrate
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
probably the natural substrate
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
-
-
-
?
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
-
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
-
-
?
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
-
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
-
-
?
additional information
?
-
-
brassicasterols have regulatory function in the plants concerning growth and development, the enzyme is up-regulated by several growth-promoting hormones including brassinolide and auxin, overview
-
-
?
additional information
?
-
-
14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
-
-
?
additional information
?
-
-
important essential enzyme of cholesterol biosynthesis from lanosterol
-
-
?
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis, sterol content in vivo
-
-
?
additional information
?
-
-
enzyme involved in sterol, phytosterol, biosynthesis, DELTA8,14-sterols are intermediates in the biosynthesis of higher plant sterols, phytosterols
-
-
?
additional information
?
-
-
14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
-
-
?
additional information
?
-
-
important essential enzyme of cholesterol biosynthesis from lanosterol
-
-
?
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis, sterol content in vivo
-
-
?
additional information
?
-
enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
-
-
?
additional information
?
-
enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
-
-
?
additional information
?
-
-
enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
-
-
?
additional information
?
-
-
C14SR is encoded by the TM7SF2 gene. TM7SF2 but not LBR, gene expression is regulated by cell sterol levels in HepG2 (human) and H-35 (rat) hepatoma cells. Primary role of C14SR in human cholesterol biosynthesis
-
-
?
additional information
?
-
-
role of LBR in the cholesterol biosynthesis pathway is unclear
-
-
?
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis
-
-
?
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis, sterol content in vivo
-
-
?
additional information
?
-
-
catalyzes anaerobically NADPH-dependent reduction of 14-double bond of 8,14-diene or 7,14-diene sterols that are sterol intermediates formed during C-32 demethylation in cholesterol biosynthesis from lanosterol in mammals
-
-
?
additional information
?
-
-
catalyzes anaerobically NADPH-dependent reduction of 14-double bond of 8,14-diene or 7,14-diene sterols that are sterol intermediates formed during C-32 demethylation in cholesterol biosynthesis from lanosterol in mammals
-
-
?
additional information
?
-
-
reduction of 14-double bond of sterol-conjugated dienes
-
-
?
additional information
?
-
-
14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
-
-
?
additional information
?
-
-
microsomal enzyme of cholesterol biosynthesis from lanosterol
-
-
?
additional information
?
-
-
important essential enzyme of cholesterol biosynthesis from lanosterol
-
-
?
additional information
?
-
-
reduction of DELTA8,14-intermediate in ergosterol biosynthetic pathway to DELTA8-intermediate occurs by the trans addition of two hydrogens to the 14alpha- and 15beta-positions
-
-
?
additional information
?
-
-
enzyme of biosynthetic pathways of ergosterol, major sterol in yeast, and cholesterol including a DELTA8,14-sterol intermediate as result of demethylation of lanosterol at C-14
-
-
?
additional information
?
-
-
essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
-
-
?
additional information
?
-
-
essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
-
-
?
additional information
?
-
-
reduction of DELTA8,14-intermediate in ergosterol biosynthetic pathway to DELTA8-intermediate occurs by the trans addition of two hydrogens to the 14alpha- and 15beta-positions
-
-
?
additional information
?
-
-
enzyme of biosynthetic pathways of ergosterol, major sterol in yeast, and cholesterol including a DELTA8,14-sterol intermediate as result of demethylation of lanosterol at C-14
-
-
?
additional information
?
-
-
essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
-
-
?
additional information
?
-
-
enzyme is involved in de novo synthesis of progesterone from lanosterol via cholesterol, pathway overview
-
-
?
additional information
?
-
-
DELTA8,14 derivatives are the only substrates to be transformed under normal biosynthetic conditions
-
-
?
additional information
?