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Literature summary for 1.3.1.70 extracted from

  • Hu, C.; Zhou, M.; Wang, W.; Sun, X.; Yarden, O.; Li, S.
    Abnormal ergosterol biosynthesis activates transcriptional responses to antifungal azoles (2018), Front. Microbiol., 9, 9-9 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.70

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ Neurospora crassa
-
 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
-
 ?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ Neurospora crassa DSM 1257
-
 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Neurospora crassa P38670
-
-
Neurospora crassa DSM 1257 P38670
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
 Neurospora crassa 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
-
 ?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
 Neurospora crassa DSM 1257 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
C-14 sterol reductase
-
 Neurospora crassa
ERG24
-
 Neurospora crassa

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Neurospora crassa

Expression

Organism Comment Expression
Neurospora crassa after CuSO4 is added to the medium, the mRNA level of the enzyme gene is dramatically induced by at least 6.5fold. Deletion of C-8 sterol isomerase (erg2) also induces the expression of the enzyme up