Cloned (Comment) | Organism |
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gene PrR1, PrR1 is co-expressed with many characterized genes involved in secondary cell wall biosynthesis, gene co-expression networks for Arabidopsis thaliana PrR1 and PrR2, overview. PrR1 is regulated by the secondary cell wall transcription factors SND1 and MYB46 | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the prr1-1 knock-out mutant SALK_058467 contains a T-DNA insertion within an exonic region of the PrR1 gene. The concentration of the lignan, pinoresinol, is 4.8fold higher in the loss-of-function prr1 mutant than in control plants. Impact of loss of function of PrR1 on the cellular distribution of lignin | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
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Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
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(-)-pinoresinol + NADPH + H+ | Arabidopsis thaliana | - |
(-)-lariciresinol + NADP+ | - |
? | |
additional information | Arabidopsis thaliana | (-)-pinoresinol is successively converted into (-)-lariciresinol and (+)-secoisolariciresinol by isozyme PrR1, cf. Ec 1.23.1.4 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q9FVQ6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | PrR1 is highly expressed in lignified inflorescence stem tissue | Arabidopsis thaliana | - |
seed coat | - |
Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(-)-pinoresinol + NADPH + H+ | - |
Arabidopsis thaliana | (-)-lariciresinol + NADP+ | - |
? | |
additional information | (-)-pinoresinol is successively converted into (-)-lariciresinol and (+)-secoisolariciresinol by isozyme PrR1, cf. Ec 1.23.1.4 | Arabidopsis thaliana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
bi-functional pinoresinol/lariciresinol reductase | - |
Arabidopsis thaliana |
More | cf. EC 1.23.1.4 | Arabidopsis thaliana |
pinoresinol reductase | - |
Arabidopsis thaliana |
pinoresinol reductase 1 | - |
Arabidopsis thaliana |
PLR | - |
Arabidopsis thaliana |
PrR1 | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
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malfunction | the loss-of-function mutant of PrR1 shows, in addition to elevated levels of pinoresinol, significantly decreased lignin content and a slightly altered lignin structure with lower abundance of cinnamyl alcohol end groups. Stimulated Raman scattering (SRS) microscopy analysis indicates that the lignin content of the prr1-1 loss-of-function mutant is similar to that of wild-type plants in xylem cells, which exhibit a normal phenotype, but is reduced in the fiber cells. The concentration of the lignan, pinoresinol, is 4.8fold higher in the loss-of-function prr1 mutant than in control plants. Impact of loss of function of PrR1 on the cellular distribution of lignin. The PrR1 isozyme mutation alters the expression level of diverse genes, overview | Arabidopsis thaliana |
metabolism | pinoresinol is successively converted into lariciresinol and secoisolariciresinol by PrR. Secoisolariciresinol is glycosylated to secoisolariciresinol diglucoside (SDG). PLR has enantiomeric control on the lignan biosynthetic pathway | Arabidopsis thaliana |
physiological function | pinoresinol reductase (PrR) catalyzes the conversion of the lignan pinoresinol to lariciresinol in Arabidopsis thaliana, where it is encoded by two genes, PrR1 and PrR2, that appear to act redundantly. Association of the lignan biosynthetic enzyme encoded by PrR1 with secondary cell wall biosynthesis in fiber cells. PrR1 is regulated by the secondary cell wall transcription factors SND1 and MYB46. PrR1 plays a role in lignan biosynthesis in aerial tissue | Arabidopsis thaliana |