Activating Compound | Comment | Organism | Structure |
---|---|---|---|
EDTA | - |
Rattus sp. | |
reduced thiols | e.g. dithiothreitol | Rattus sp. | |
reduced thiols | e.g. ethanethiol, glutathione | Rattus sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-Thiouracil | - |
Rattus sp. | |
6-Propyl-2-thiouracil | inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity | Rattus sp. | |
additional information | 3,3',5'-triiodothyronine blocks 5'-deiodination of L-thyroxine blocks 5'-deiodination of 3,3',5'-triiodothyronine | Rattus sp. | |
SH-group blocking reagents | - |
Rattus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | Rattus sp. | isoenzyme type I | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodothyronine + AH2 | Rattus sp. | isoenzyme type II and type III | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodothyronine + AH2 | Rattus sp. | - |
3,5-diiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Rattus sp. | thyronine 5'-deiodinase type II | 3,3',5-triiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Rattus sp. | idothyronine 5'-deiodinase type I | 3,3',5'-triiodothyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus sp. | - |
overview | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | reaction mechanism of thyronine 5'-deiodinase | Rattus sp. | |
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | type III, inner (tyrosyl) ring deiodination | Rattus sp. | |
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | type II, outer ring (phenolic) deiodination | Rattus sp. | |
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | type I, outer ring (phenolic) deiodination | Rattus sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus sp. | - |
liver | - |
Rattus sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | isoenzyme type I | Rattus sp. | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodothyronine + AH2 | - |
Rattus sp. | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodothyronine + AH2 | isoenzyme type II and type III | Rattus sp. | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodothyronine + AH2 | - |
Rattus sp. | 3,5-diiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | thyronine 5'-deiodinase type II | Rattus sp. | 3,3',5-triiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | thyronine 5-deiodinase type | Rattus sp. | 3,3',5'-triiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | idothyronine 5'-deiodinase type I | Rattus sp. | 3,3',5'-triiodothyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
iodothyronine 5'-deiodinase | iodothyronine 5'-deiodinase type | Rattus sp. |
iodothyronine 5-deiodinase | iodothyronine 5-deiodinase type | Rattus sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Rattus sp. |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 8 | - |
Rattus sp. |