Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cationic buffers | - |
Rattus norvegicus | |
ion-exchange resins | - |
Rattus norvegicus | |
NADH | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.018 | - |
4-Aminobutyraldehyde | 250 mM phosphate preparation, constant substrate 1 mM NAD+ | Rattus norvegicus | |
0.054 | - |
acetaldehyde | 250 mM phosphate preparation, constant substrate 1 mM NAD+ | Rattus norvegicus | |
0.081 | - |
4-Aminobutyraldehyde | 400 mM phosphate preparation, constant substrate 1 mM NAD+ | Rattus norvegicus | |
0.252 | - |
Succinic semialdehyde | 400 mM phosphate preparation, constant substrate 1 mM NAD+ | Rattus norvegicus | |
0.285 | - |
Betaine aldehyde | 250 mM phosphate preparation, constant substrate 1 mM NAD+ | Rattus norvegicus | |
5.428 | - |
Succinic semialdehyde | 250 mM phosphate preparation, constant substrate 1 mM NAD+ | Rattus norvegicus | |
6.9 | - |
acetaldehyde | 400 mM phosphate preparation, constant substrate 1 mM NAD+ | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52000 | - |
2 * 52000, SDS-PAGE | Rattus norvegicus |
112000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-aminobutanal + NAD+ + H2O | Rattus norvegicus | involved in the metabolism of biogenic amines and in the synthesis of 4-aminobutyric acid | 4-aminobutanoate + NADH + H+ | - |
? | |
4-aminobutanal + NAD+ + H2O | Rattus norvegicus Wistar- | involved in the metabolism of biogenic amines and in the synthesis of 4-aminobutyric acid | 4-aminobutanoate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar-strain | - |
Rattus norvegicus Wistar- | - |
Wistar-strain | - |
Purification (Comment) | Organism |
---|---|
using column chromatography on hydroxylapatite, precipitation with ammonium sulfate, column chromatography on Sephacryl S-300, Phenyl-superose, 5'-AMP-Sepharose and hydroxylapatite | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestinal mucosa | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
Storage Stability | Organism |
---|---|
4°C, 250 mM phosphate, pH 6.8, in the presence of 4 mM dithiothreitol, activity decreases by 20-30% after 7 days, freezing resultes in complete inactivation | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-aminobutanal + NAD+ + H2O | - |
Rattus norvegicus | 4-aminobutanoate + NADH + H+ | - |
? | |
4-aminobutanal + NAD+ + H2O | involved in the metabolism of biogenic amines and in the synthesis of 4-aminobutyric acid | Rattus norvegicus | 4-aminobutanoate + NADH + H+ | - |
? | |
4-aminobutanal + NAD+ + H2O | - |
Rattus norvegicus Wistar- | 4-aminobutanoate + NADH + H+ | - |
? | |
4-aminobutanal + NAD+ + H2O | involved in the metabolism of biogenic amines and in the synthesis of 4-aminobutyric acid | Rattus norvegicus Wistar- | 4-aminobutanoate + NADH + H+ | - |
? | |
acetaldehyde + NAD+ + H2O | - |
Rattus norvegicus | acetate + NADH + H+ | - |
? | |
acetaldehyde + NAD+ + H2O | - |
Rattus norvegicus Wistar- | acetate + NADH + H+ | - |
? | |
betaine aldehyde + NAD+ + H2O | - |
Rattus norvegicus | betaine + NADH + H+ | - |
? | |
betaine aldehyde + NAD+ + H2O | - |
Rattus norvegicus Wistar- | betaine + NADH + H+ | - |
? | |
succinate semialdehyde + NAD+ | - |
Rattus norvegicus | succinate + NADH + H+ | - |
? | |
succinate semialdehyde + NAD+ | - |
Rattus norvegicus Wistar- | succinate + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 52000, SDS-PAGE | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | 9.5 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus |