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Information on EC 1.2.1.19 - aminobutyraldehyde dehydrogenase
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1.2.1.19 aminobutyraldehyde dehydrogenaseIUBMB Comments
The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates . The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54 gamma-guanidinobutyraldehyde dehydrogenase). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. The enzyme forms part of the arginine-catabolism pathway and belongs in the aldehyde dehydrogenase superfamily .
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Word Map
- 1.2.1.19
-
badhs
- choline
-
osmoprotectant
-
1.2.1.8
-
spinacia
-
2-acetyl-1-pyrroline
- glycinebetaine
- 3-aminopropionaldehyde
-
suaeda
-
halophyte
-
fragrant
-
hypochondriacus
- aldh10s
-
amaranthus
-
liaotungensis
-
jasmine
-
basmati
- 4-aminobutyrate
- synthesis
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
betaine aldehyde dehydrogenase, amadh, aminoaldehyde dehydrogenase, aldh10a8, 4-aminobutyraldehyde dehydrogenase, aldh10a9, gamma-aminobutyraldehyde dehydrogenase, slamadh1, abaldh, 4-aminobutanal dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
4-aminobutanal dehydrogenase
4-aminobutyraldehyde dehydrogenase
ABAL dehydrogenase
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-
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ABALDH
AMADH
AMADH1
AMADH2
aminoaldehyde dehydrogenase
dehydrogenase, aminobutyraldehyde
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-
-
-
EC 1.5.1.35
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-
formerly
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gamma-aminobutyraldehyde dehydroganase
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-
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gamma-aminobutyraldehyde dehydrogenase
gamma-guanidinobutyraldehyde dehydrogenase
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-
-
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YdcW
additional information
4-aminobutanal dehydrogenase
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-
-
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4-aminobutyraldehyde dehydrogenase
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-
-
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gamma-aminobutyraldehyde dehydrogenase
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-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + H+
A-stereospecific with respect to NAD+
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4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + H+
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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-
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-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
4-aminobutanal:NAD+ 1-oxidoreductase
The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates [9]. The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54 gamma-guanidinobutyraldehyde dehydrogenase). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. The enzyme forms part of the arginine-catabolism pathway [8] and belongs in the aldehyde dehydrogenase superfamily [9].
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CAS REGISTRY NUMBER
COMMENTARY
9028-98-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,2-dimethyl-3-propionylaminopropanal + NAD+ + H2O
2,2-dimethyl-3-propionylaminopropanoate + NADH + 2 H+
-
-
-
?
2,2-dimethyl-4-aminobutanal + NAD+ + H2O
2,2-dimethyl-4-aminobutanoate + NADH + 2 H+
-
-
-
?
2,2-dimethyl-4-propionylaminobutanal + NAD+ + H2O
2,2-dimethyl-4-propionylaminobutanoate + NADH + 2 H+
-
-
-
?
2-methyl-3-butyrylaminopropanal + NAD+ + H2O
2-methyl-3-butyrylaminopropanoate + NADH + 2 H+
-
-
-
?
2-methyl-3-propionylaminopropanal + NAD+ + H2O
2-methyl-3-propionylaminopropanoate + NADH + 2 H+
-
-
-
?
2-methyl-4-aminobutanal + NAD+ + H2O
2-methyl-4-aminobutanoate + NADH + 2 H+
-
-
-
?
2-methyl-4-propionylaminobutanal + NAD+ + H2O
2-methyl-4-propionylaminobutanoate + NADH + 2 H+
-
-
-
?
3-acetaminopropanal + NAD+ + H2O
3-acetaminopropanoate + NADH + 2 H+
-
-
-
?
3-adipylaminopropanal + NAD+ + H2O
3-adipylaminopropanoate + NADH + 2 H+
-
-
-
?
3-aminobutanal + NAD+ + H2O
3-aminobutanoate + NADH + 2 H+
best substrate
-
-
?
3-aminopropionaldehyde + NAD+ + H2O
3-aminopropanoate + NADH + 2 H+
-
-
-
?
3-aminopropionaldehyde + NAD+ + H2O
3-aminopropanoate + NADH + H+
100% activity
-
-
?
3-aminopropionaldehyde + NAD+ + H2O
3-aminopropionate + NADH + 2 H+
best substrate
-
-
?
3-butyrylaminopropanal + NAD+ + H2O
3-butyrylaminpropanoate + NADH + 2 H+
-
-
-
?
3-methyl-3-butyrylaminopropanal + NAD+ + H2O
3-methyl-3-butyrylaminopropanoate + NADH + 2 H+
-
-
-
?
3-methyl-4-aminobutanal + NAD+ + H2O
3-methyl-4-aminobutanoate + NADH + 2 H+
-
-
-
?
3-propionylaminopropanal + NAD+ + H2O
3-propionylaminopropanoate + NADH + 2 H+
-
-
-
?
3-pyridine carboxaldehyde + NAD+ + H2O
3-pyridine carboxylic acid + NADH + 2 H+
-
-
-
?
3-valerylaminopropanal + NAD+ + H2O
3-valerylaminopropanoate + NADH + 2 H+
-
-
-
?
4-acetaminobutanal + NAD+ + H2O
4-acetaminobutanoate + NADH + 2 H+
-
-
-
?
4-butyrylaminobutanal + NAD+ + H2O
4-butyrylaminobutanoate + NADH + 2 H+
-
-
-
?
4-guanidino-2-hydroxybutyraldehyde + NAD+ + H2O
4-guanidino-2-hydroxybutanoate + NADH + H+
4-guanidinobutyraldehyde + NADP+ + H2O
4-guanidinobutanoate + NADPH
-
-
-
-
?
4-propionylaminobutanal + NAD+ + H2O
4-propionylaminobutanoate + NADH + 2 H+
-
-
-
?
4-pyridine carboxaldehyde + NAD+ + H2O
4-pyridine carboxylic acid + NADH + 2 H+
-
-
-
?
4-valerylaminobutanal + NAD+ + H2O
4-valerylaminobutanoate + NADH + 2 H+
-
-
-
?
aminoacetaldehyde + NAD+ + H2O
aminoacetate + NADH
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12% of activity with 3-aminopropionaldehyde
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-
?
N,N,N-trimethyl-4-aminobutyraldehyde + NAD+ + H2O
N,N,N-trimethyl-4-aminobutanoate + NADH + 2 H+
N,N,N-trimethyl-4-aminobutyraldehyde + NAD+ + H2O
N,N,N-trimethyl-4-aminobutanoate + NADH + H+
N-(3-aminopropyl)-4-aminobutyraldehyde + NAD+ + H2O
N-(3-aminopropyl)-4-aminobutanoate + NADH
-
11% of activity with 3-aminopropionaldehyde
-
-
?
N-acetyl-3-aminopropionaldehyde + NAD+ + H2O
N-acetyl-3-aminopropionate + NADH + H+
-
-
-
?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
best substrate
-
-
?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
-
-
-
?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
best substrate
-
-
?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
-
-
-
?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
-
17% the rate of 4-aminobutyraldehyde reduction
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?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
-
17% the rate of 4-aminobutyraldehyde reduction
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?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
-
-
-
?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
best substrate
-
-
?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
high activity
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-
?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
-
-
-
?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
best substrate
-
-
?
3-cyanopropionaldehyde + NAD+ + H2O
3-cyanopropanoate + NADH + H+
108% activity compared to 3-aminopropionaldehyde
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?
3-cyanopropionaldehyde + NAD+ + H2O
3-cyanopropanoate + NADH + H+
99% activity compared to 3-aminopropionaldehyde
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-
?
3-guanidinopropionaldehyde + NAD+ + H2O
3-guanidinopropanoate + NADH + H+
12% activity compared to 3-aminopropionaldehyde
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-
?
3-guanidinopropionaldehyde + NAD+ + H2O
3-guanidinopropanoate + NADH + H+
17% activity compared to 3-aminopropionaldehyde
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-
?
4-amino-2-hydroxybutyraldehyde + NAD+ + H2O
4-amino-2-hydroxybutanoate + NADH + H+
13% activity compared to 3-aminopropionaldehyde
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-
?
4-amino-2-hydroxybutyraldehyde + NAD+ + H2O
4-amino-2-hydroxybutanoate + NADH + H+
20% activity compared to 3-aminopropionaldehyde
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-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + 2 H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + 2 H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + 2 H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + 2 H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + 2 H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
role in putrescine degradative pathway
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
role in putrescine degradative pathway
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
Desulfovibrio vulgaris Marburg / DSM 2119
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
Desulfovibrio vulgaris Marburg / DSM 2119
-
role in putrescine degradative pathway
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
specific for
-
?, ir
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
role in putrescine degradative pathway
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
role in putrescine degradative pathway
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
role in putrescine degradative pathway
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
specific for
-
ir
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
involved in amino aldehyde metabolism, connects metabolism of a diamine putrescine with that of the inhibitory neurotransmitter 4-aminobutyric acid
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
degradation of agmatine
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
role in putrescine degradative pathway
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
role in putrescine degradative pathway
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
gamma-aminobutyrate metabolism
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
involved in the arginine decarboxylase pathway
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
involved in the metabolism of biogenic amines and in the synthesis of 4-aminobutyric acid
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
-
-
?
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
involved in the metabolism of biogenic amines and in the synthesis of 4-aminobutyric acid
-
?
4-aminobutyraldehyde + NAD+ + H2O
4-aminobutanoate + NADH
-
51% of activity with 3-aminopropionaldehyde
-
-
?
4-aminobutyraldehyde + NAD+ + H2O
4-aminobutanoate + NADH
-
-
-
?
4-aminobutyraldehyde + NAD+ + H2O
4-aminobutanoate + NADH + 2 H+
-
-
-
-
?
4-aminobutyraldehyde + NAD+ + H2O
4-aminobutanoate + NADH + 2 H+
-
-
-
?
4-aminobutyraldehyde + NAD+ + H2O
4-aminobutanoate + NADH + 2 H+
-
-
-
-
?
4-aminobutyraldehyde + NAD+ + H2O
4-aminobutanoate + NADH + H+
36% activity compared to 3-aminopropionaldehyde
-
-
?
4-aminobutyraldehyde + NAD+ + H2O
4-aminobutanoate + NADH + H+
82% activity compared to 3-aminopropionaldehyde
-
-
?
4-aminobutyraldehyde + NADP+ + H2O
4-aminobutanoate + NADPH
-
-
-
?
4-guanidino-2-hydroxybutyraldehyde + NAD+ + H2O
4-guanidino-2-hydroxybutanoate + NADH + H+
22% activity compared to 3-aminopropionaldehyde
-
-
?
4-guanidino-2-hydroxybutyraldehyde + NAD+ + H2O
4-guanidino-2-hydroxybutanoate + NADH + H+
25% activity compared to 3-aminopropionaldehyde
-
-
?
4-guanidinobutyraldehyde + NAD+ + H2O
4-guanidinobutanoate + NADH
-
52% of activity with 3-aminopropionaldehyde
-
-
?
4-guanidinobutyraldehyde + NAD+ + H2O
4-guanidinobutanoate + NADH + 2 H+
-
-
-
?
4-guanidinobutyraldehyde + NAD+ + H2O
4-guanidinobutanoate + NADH + 2 H+
-
-
-
?
4-guanidinobutyraldehyde + NAD+ + H2O
4-guanidinobutanoate + NADH + H+
29% activity compared to 3-aminopropionaldehyde
-
-
?
4-guanidinobutyraldehyde + NAD+ + H2O
4-guanidinobutanoate + NADH + H+
30% activity compared to 3-aminopropionaldehyde
-
-
?
4-guanidinobutyraldehyde + NAD+ + H2O
4-guanidinobutyrate + NADH + H+
-
-
-
?
4-guanidinobutyraldehyde + NAD+ + H2O
4-guanidinobutyrate + NADH + H+
-
-
-
?
4-guanidinobutyraldehyde + NAD+ + H2O
4-guanidinobutyrate + NADH + H+
-
-
-
?
4-guanidinobutyraldehyde + NAD+ + H2O
4-guanidinobutyrate + NADH + H+
-
involved in the L-arginine catabolism
-
?
4-guanidinobutyraldehyde + NAD+ + H2O
4-guanidinobutyrate + NADH + H+
-
-
-
?
4-guanidinobutyraldehyde + NAD+ + H2O
4-guanidinobutyrate + NADH + H+
-
involved in the L-arginine catabolism
-
?
5-aminovaleraldehyde + NAD+ + H2O
5-aminovalerate + NADH + H+
-
-
-
?
5-aminovaleraldehyde + NAD+ + H2O
5-aminovalerate + NADH + H+
-
-
-
?