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Information on EC 1.2.1.19 - aminobutyraldehyde dehydrogenase

for references in articles please use BRENDA:EC1.2.1.19

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IUBMB Comments

The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates . The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54 γ-guanidinobutyraldehyde dehydrogenase). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. The enzyme forms part of the arginine-catabolism pathway and belongs in the aldehyde dehydrogenase superfamily .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
betaine aldehyde dehydrogenase, amadh, aminoaldehyde dehydrogenase, aldh10a8, 4-aminobutyraldehyde dehydrogenase, aldh10a9, gamma-aminobutyraldehyde dehydrogenase, slamadh1, 4-aminobutanal dehydrogenase, abaldh, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
L-lysine degradation I, L-lysine degradation X, putrescine degradation I, putrescine degradation IV, putrescine degradation V